scholarly journals Adenoid cystic carcinoma: A case of rare breast cancer

2022 ◽  
Vol 17 (3) ◽  
pp. 690-692
Author(s):  
Claudia Gordillo ◽  
Anjeza Chukus
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

scholarly journals Adenoid cystic carcinoma of the breast: case report

Mastology ◽  
2021 ◽  
Vol 31 ◽  
Author(s):  
Matheus Lavigne Marinho ◽  
Alexandre Tafuri ◽  
Carlos Alberto da Silva Ramos ◽  
Antônio Alexandre Lisbôa Ladeia ◽  
Luciana de Carvalho Azevedo
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Triple Negative ◽  
Breast Conserving Surgery ◽  
Genetic Alterations ◽  
Good Prognosis ◽  
Carcinoma Of The Breast ◽  
Adenoid Cystic ◽  
Molecular Aspects ◽  
Peculiar Behavior

Adenoid cystic carcinoma (AdCC) of the breast is an uncommon invasive lobular neoplasm whose morphology is similar to the homonymous tumor of salivary glands and with a peculiar behavior toward the “triple-negative” (TN) profile. Tumors belonging to this family do not immunohistochemically express three of the main prognostic biomarkers and tend to show a more aggressive behavior. However, this rare histological pattern of breast cancer is generally associated with good prognosis. In this study, the authors describe the case of a 49-year-old woman diagnosed with this rare malignant tumor and who underwent breast-conserving surgery. Recent studies have aimed to understand the genes, genetic alterations, and etiological aspects related to the still obscure etiopathogenesis of AdCC. Thus, morphological and molecular aspects relevant to AdCC and reported in the literature will be discussed.

scholarly journals Advanced Tracheal Adenoid Cystic Carcinoma with Thyroid Invasion Mimicking Thyroid Cancer Treated with Definitive Radiation: Case Report and Review of the Literature

2017 ◽  
Vol 10 (2) ◽  
pp. 706-712 ◽  
Author(s):  
Sondos Al Khatib ◽  
Wafa Asha ◽  
Omar Khzouz ◽  
Farid Barakat ◽  
Jamal Khader
Keyword(s):  
Breast Cancer ◽  
Thyroid Cancer ◽  
Case Report ◽  
Adenoid Cystic Carcinoma ◽  
Breast Cancer Survivor ◽  
Literature Search ◽  
Neck Swelling ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Adenoid Cystic

A 54-year-old female patient, a breast cancer survivor and a case of unresectable adenoid cystic carcinoma of the trachea, with thyroid invasion, presented with suprasternal neck swelling mimicking thyroid primary. A literature search was undertaken to highlight this rare presentation. There have been few reports in the literature describing tracheal adenoid cystic carcinoma involving the thyroid.

scholarly journals Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Wenxiang Zhang ◽  
Yi Fang ◽  
Zhihui Zhang ◽  
Jing Wang
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Local Recurrence ◽  
Adenoid Cystic Carcinoma ◽  
Distant Metastasis ◽  
Hormone Receptor ◽  
Clinical Presentation ◽  
Hormone Receptor Positive ◽  
Adenoid Cystic

ObjectiveThe purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.MethodsA total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed.ResultsFourteen patients were diagnosed with ACC of the breast, out of 23205 total patients treated for breast cancer (0.06%). All but three patients were postmenopausal, with a median age at diagnosis of 60.5 years (range, 39–73 years). The most common clinical presentation was a palpable mass (85.7%), and the imaging characteristics of all patients on color Doppler ultrasound and mammography were nonspecific. Six patients (42.9%) were suspected of having ACC by fine-needle aspiration cytology (FNAC) and were confirmed by postoperative histology and immunohistochemistry. All 14 patients underwent surgery, and no patient had a positive lymph node status. Median tumor size was 1.75 cm (range, 1–3 cm). Eight/14 (57.1%) patients were hormone receptor negative (HR−) and HER-2/neu (−) (HER2−). The remaining patients were hormone receptor positive (HR+). There was no significant difference in clinicopathological characteristics between the HR+ group and the HR- group (P>0.05). The mean follow-up period was 57 months. Local recurrence occurred in 14.3% of patients, 1.7% of patients had distant metastasis, all patients with local recurrence or distant metastasis were in the HR (-) group, and all patients were alive at the last follow-up.ConclusionACC of the breast cannot be simply summarized as triple-negative breast cancer because it also includes a small number of hormone receptor-positive breast cancers. Establishing a preoperative diagnosis is difficult on the basis of clinical imaging examination, FNAC may be useful tool in the diagnosis. the final diagnosis can only be assessed based on the results of the histopathological and immunohistochemical examination. Breast-conserving surgery may be an alternative treatment strategy, and axillary lymph node dissection or sentinel node biopsy may not be necessary in some cases.

scholarly journals Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

2016 ◽  
pp. bcr2015213704 ◽  
Author(s):  
Daniel Romeira ◽  
Débora Cardoso ◽  
Helena Miranda ◽  
Ana Martins
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Good Prognosis ◽  
Adenoid Cystic

scholarly journals Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma

2014 ◽  
Vol 4 (10) ◽  
pp. 1154-1167 ◽  
Author(s):  
Alexander Stoeck ◽  
Serguei Lejnine ◽  
Andrew Truong ◽  
Li Pan ◽  
Hongfang Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Adenoid Cystic

scholarly journals Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer

2016 ◽  
Vol 29 (11) ◽  
pp. 1292-1305 ◽  
Author(s):  
Nicola Fusco ◽  
Felipe C Geyer ◽  
Maria R De Filippo ◽  
Luciano G Martelotto ◽  
Charlotte K Y Ng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Grade ◽  
Carcinoma Of The Breast ◽  
Adenoid Cystic ◽  
Genetic Events

1 Tumour associated macrophages in HPV-related carcinoma with adenoid cystic like features of the sinonasal tract; a review of three cases

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A1-A1 ◽  
Author(s):  
Kasimu Adoke ◽  
Jonathan Madukwe ◽  
Faruk Mohammed
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
Sinonasal Tract ◽  
List Type ◽  
Tumor Associated Macrophages ◽  
Mesenchymal Transition ◽  
Adenoid Cystic ◽  
Cd 68

BackgroundHPV- related carcinoma with adenoid cystic like features of the sinonasal tract is a newly describe entity with histological and immunophenotypic features of surface derived and salivary gland carcinoma. It affects females more than males with age range of 40–70 years and is linked to high risk HPV infection. Most cases present with nasal obstruction and epistaxis. They consist of basaoid cells growing in various sizes separated by fibrocollagenous stroma.1 It is believed to have a good prognosis. Tumor-associated macrophages (TAMs) are activated macrophages associated with tumor progression in various cancers. TAMs can polarize M1 or M2 type. M1 has a pro-inflammatory function and kills pathogens. Conversely, M2 shows immunosuppressive action and promotes tumor growth. CD68 is known as a pan-macrophage marker.2 We evaluate the CD68 expression in three cases of HPV- related carcinoma with adenoid cystic like features of the sinonasal tract.MethodsThree cases of HPV-related carcinoma with adenoid cystic like features were retrieved from our archives and stained with p16 and CD68 antibodies. Data was analyzed using spss version 21.ResultsPatient ages were 46, 48 and 56 years old respectively, with a female to male ratio of 2:1. Histology showed epithelial surface dysplasia overlying basaloid cell growing in tubular and crbriform patterns. All were strongly positive for p16 stains (figure 1). CD 68 showed intratumoral and peritumoral expression in two cases while, one case showed only peritumoral expression. Infiltration of tumour associated macrophages (M2) CD68 cell in this study is associated with increase recurrence of HPV-related adenoid cystic carcinoma of the sinonasal tract (figure 2).Abstract 1 Figure 1p16 staining in HPV- related adenoid cystic carcinoma of the sinonasal tractAbstract 2 Figure 2CD 68 staining of the stroma in HPV-related adenoid cystic carcinoma of sinonasal tractConclusionsThe targeting of TAMs in HPV-related adenoid cystic carcinoma of the sinonasal tract and other cancers should be explored in the future using macrophage targeted approach.Ethics ApprovalHealth research ethics committee ABUTH/HREC/Y/2017ReferencesBurugu S, Asleh-Aburaya K, Nielsen TO. Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication. Breast Cancer 2017; 24:3–15.Fan QM, Jing YY, Yu GF, Kou XR, Ye F, Gao L, Li R, Zhao QD, Yang Y, Lu ZH, Wei LX. Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett 2017;352:160–168.

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