Independent validation of a dedicated commissioning software and investigation of the direction dependence of the field symmetry for the LIAC intraoperative electron radiotherapy accelerator

Author(s):  
Mohammad Amin Mosleh-Shirazi ◽  
Razieh Rashidfar ◽  
Sareh Karbasi ◽  
Mehran Pashnehsaz ◽  
Maziyar Mahdavi
Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1292
Author(s):  
Luisa Agnello ◽  
Alessandro Iacona ◽  
Salvatore Maestri ◽  
Bruna Lo Sasso ◽  
Rosaria Vincenza Giglio ◽  
...  

(1) Background: The early detection of sepsis is still challenging, and there is an urgent need for biomarkers that could identify patients at a high risk of developing it. We recently developed an index, namely the Sepsis Index (SI), based on the combination of two CBC parameters: monocyte distribution width (MDW) and mean monocyte volume (MMV). In this study, we sought to independently validate the performance of SI as a tool for the early detection of patients at a high risk of sepsis in the Emergency Department (ED). (2) Methods: We enrolled all consecutive patients attending the ED with a request of the CBC. MDW and MMV were measured on samples collected in K3-EDTA tubes on the UniCel DxH 900 haematology analyser. SI was calculated based on the MDW and MMV. (3) Results: We enrolled a total of 703 patients stratified into four subgroups according to the Sepsis-2 criteria: control (498), infection (105), SIRS (52) and sepsis (48). The sepsis subgroup displayed the highest MDW (median 27.5, IQR 24.6–32.9) and SI (median 1.15, IQR 1.05–1.29) values. The ROC curve analysis for the prediction of sepsis showed a good and comparable diagnostic accuracy of the MDW and SI. However, the SI displayed an increased specificity, positive predictive value and positive likelihood ratio in comparison to MDW alone. (4) Conclusions: SI improves the diagnostic accuracy of MDW for sepsis screening.


2021 ◽  
Vol 13 (3) ◽  
pp. 408
Author(s):  
Charles Nickmilder ◽  
Anthony Tedde ◽  
Isabelle Dufrasne ◽  
Françoise Lessire ◽  
Bernard Tychon ◽  
...  

Accurate information about the available standing biomass on pastures is critical for the adequate management of grazing and its promotion to farmers. In this paper, machine learning models are developed to predict available biomass expressed as compressed sward height (CSH) from readily accessible meteorological, optical (Sentinel-2) and radar satellite data (Sentinel-1). This study assumed that combining heterogeneous data sources, data transformations and machine learning methods would improve the robustness and the accuracy of the developed models. A total of 72,795 records of CSH with a spatial positioning, collected in 2018 and 2019, were used and aggregated according to a pixel-like pattern. The resulting dataset was split into a training one with 11,625 pixellated records and an independent validation one with 4952 pixellated records. The models were trained with a 19-fold cross-validation. A wide range of performances was observed (with mean root mean square error (RMSE) of cross-validation ranging from 22.84 mm of CSH to infinite-like values), and the four best-performing models were a cubist, a glmnet, a neural network and a random forest. These models had an RMSE of independent validation lower than 20 mm of CSH at the pixel-level. To simulate the behavior of the model in a decision support system, performances at the paddock level were also studied. These were computed according to two scenarios: either the predictions were made at a sub-parcel level and then aggregated, or the data were aggregated at the parcel level and the predictions were made for these aggregated data. The results obtained in this study were more accurate than those found in the literature concerning pasture budgeting and grassland biomass evaluation. The training of the 124 models resulting from the described framework was part of the realization of a decision support system to help farmers in their daily decision making.


2021 ◽  
Vol 11 (6) ◽  
Author(s):  
A. Visram ◽  
C. Soof ◽  
S. V. Rajkumar ◽  
S. K. Kumar ◽  
S. Bujarski ◽  
...  

AbstractSoluble BCMA (sBCMA) levels are elevated in monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). However, the association between sBCMA levels and prognosis in MGUS and SMM has not been studied. We retrospectively analyzed sBCMA levels in stored samples from 99 MGUS and 184 SMM patients. Baseline sBCMA levels were significantly higher in MGUS and SMM patients progressing to MM during clinical follow up. When stratified according to the median baseline sBCMA level for each cohort, higher levels were associated with a shorter PFS for MGUS (HR 3.44 comparing sBCMA ≥77 vs <77 ng/mL [95% CI 2.07–5.73, p < 0.001] and SMM (HR 2.0 comparing sBCMA ≥128 vs <128 ng/mL, 95% 1.45–2.76, p < 0.001) patients. The effect of sBCMA on PFS was similar even after adjusting for the baseline MGUS or SMM risk stratification. We evaluated paired serum samples and found that sBCMA increased significantly in MGUS and SMM patients who eventually progressed to MM, whereas among MGUS non-progressors the sBCMA level remained stable. While our results require independent validation, they suggest that sBCMA may be a useful biomarker to identify MGUS and SMM patients at increased risk of progression to MM independent of the established risk models.


Author(s):  
Lawrie Skinner ◽  
Rick Knopp ◽  
Yi‐Chun Wang ◽  
Piotr Dubrowski ◽  
Karl K. Bush ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hong-Hsing Liu ◽  
Yu-Chen Lin ◽  
Chen-Shuan Chung ◽  
Kevin Liu ◽  
Ya-Hui Chang ◽  
...  

AbstractBowel microbiota is a “metaorgan” of metabolisms on which quantitative readouts must be performed before interventions can be introduced and evaluated. The study of the effects of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) on intestine transplantees indicated an increased percentage of the “other glycan degradation” pathway in 16S-rRNA-inferred metagenomes. To verify the prediction, a scoring system of carbohydrate metabolisms derived from shotgun metagenomes was developed using hidden Markov models. A significant correlation (R = 0.9, p < 0.015) between both modalities was demonstrated. An independent validation revealed a strong complementarity (R = −0.97, p < 0.002) between the scores and the abundance of “glycogen degradation” in bacteria communities. On applying the system to bacteria genomes, CBM588 had only 1 match and ranked higher than the other 8 bacteria evaluated. The gram-stain properties were significantly correlated to the scores (p < 5 × 10−4). The distributions of the scored protein domains indicated that CBM588 had a considerably higher (p < 10−5) proportion of carbohydrate-binding modules than other bacteria, which suggested the superior ability of CBM588 to access carbohydrates as a metabolic driver to the bowel microbiome. These results demonstrated the use of integrated counts of protein domains as a feasible readout for metabolic potential within bacteria genomes and human metagenomes.


2005 ◽  
Vol 38 (1) ◽  
pp. 211-216 ◽  
Author(s):  
Pang-Hung Liu ◽  
Kuei-Jung Chao ◽  
Xing-Jian Guo ◽  
Kuo-Ying Huang ◽  
Yen-Ru Lee ◽  
...  

A continuous silica film with well aligned mesochannels parallel to the Si(001) surface was found to be formed through sol–gel dip-coating of a silica precursor with nonionic ethylene oxide surfactant. Two two-dimensional mesoporous structures in centered and non-centered rectangular symmetries and with the short axes of elongated ellipsoidal pores normal to the surface were observed by X-ray and electron diffraction. Detailed transmission electron microscopy investigations were employed to view the direction dependence of the channel or pore packing in the continuous film.


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