Nutrient intake profile, growth patterns and hemoglobin levels in children with ASD – A case control study in Mysuru, India

2022 ◽  
Vol 90 ◽  
pp. 101885
Seema Siddiqi ◽  
Asna Urooj
Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 221 ◽  
Yan Zhang ◽  
Hong Zhou ◽  
Anthony Perkins ◽  
Yan Wang ◽  
Jing Sun

1993 ◽  
Vol 4 (4) ◽  
pp. 383-389 ◽  
Victoria Kalapothaki ◽  
Anastasia Tzonou ◽  
Chung-cheng Hsieh ◽  
Anna Karakatsani ◽  
Antonia Trichopoulou ◽  

2019 ◽  
Vol 43 (4) ◽  
Federico Cucchiara ◽  
Paolo Frumento ◽  
Tommaso Banfi ◽  
Gianluca Sesso ◽  
Marco Di Galante ◽  

Abstract Study Objectives Recently, a role for gain-of-function (GoF) mutations of the astrocytic potassium channel Kir4.1 (KCNJ10 gene) has been proposed in subjects with Autism–Epilepsy phenotype (AEP). Epilepsy and autism spectrum disorder (ASD) are common and complexly related to sleep disorders. We tested whether well characterized mutations in KCNJ10 could result in specific sleep electrophysiological features, paving the way to the discovery of a potentially relevant biomarker for Kir4.1-related disorders. Methods For this case–control study, we recruited seven children with ASD either comorbid or not with epilepsy and/or EEG paroxysmal abnormalities (AEP) carrying GoF mutations of KCNJ10 and seven children with similar phenotypes but wild-type for the same gene, comparing period-amplitude features of slow waves detected by fronto-central bipolar EEG derivations (F3-C3, F4-C4, and Fz-Cz) during daytime naps. Results Children with Kir4.1 mutations displayed longer slow waves periods than controls, in Fz-Cz (mean period = 112,617 ms ± SE = 0.465 in mutated versus mean period = 105,249 ms ± SE = 0.375 in controls, p < 0.001). An analog result was found in F3-C3 (mean period = 125,706 ms ± SE = 0.397 in mutated versus mean period = 120,872 ms ± SE = 0.472 in controls, p < 0.001) and F4-C4 (mean period = 127,914 ms ± SE = 0.557 in mutated versus mean period = 118,174 ms ± SE = 0.442 in controls, p < 0.001). Conclusion This preliminary finding suggests that period-amplitude slow wave features are modified in subjects carrying Kir4.1 GoF mutations. Potential clinical applications of this finding are discussed.

Janina Kitzerow ◽  
Karoline Teufel ◽  
Katrin Jensen ◽  
Christian Wilker ◽  
Christine M. Freitag

Abstract. Abstracts: Objective: In current international research, early intervention in children with autism-spectrum disorder (ASD) focuses on naturalistic developmental behavioral interventions (NDBI). The manualized Frankfurt Early Intervention Program for preschool-aged children with ASD (A-FFIP) implements NDBI principles within a low-intensity approach of 2 h intervention/week. The present case-control study established effect sizes of change in autistic symptoms, comorbid behavioral problems as well as IQ after one year. Methodology: An intervention group (N = 20; age: 3.4–7.9 years) and a treatment-as-usual control group (N = 20; age: 3.2–7.3 years) of children with ASD were matched for developmental and chronological age. The outcome measures used were the ADOS severity score, the Child Behavior Checklist, and cognitive development. Results: After one year, the A-FFIP group showed a trend towards greater improvement in autistic symptoms (η2 = .087 [95 %-CI: .000–.159]) and significantly greater improvements in cognitive development (η2 = .206 [CI: .012–.252]) and global psychopathology (η2 = .144 [CI: .001–.205]) compared to the control group. Conclusion: The efficacy of A-FFIP should be established in a larger, sufficiently powered, randomized controlled study.

Swen-Olaf Andersson ◽  
Alicja Wolk ◽  
Reinhold Bergström ◽  
Edward Giovannucci ◽  
Christina Lindgren ◽  

2018 ◽  
Vol 50 ◽  
pp. 51-59 ◽  
Kelly Barnhill ◽  
Alan Gutierrez ◽  
Maliki Ghossainy ◽  
Zabin Marediya ◽  
Morgan Devlin ◽  

The Breast ◽  
1998 ◽  
Vol 7 (2) ◽  
pp. 108-113 ◽  
P. Ghadirian ◽  
A. Lacroix ◽  
C. Perret ◽  
A. Robidoux ◽  
M. Falardeau ◽  

2021 ◽  
Vol 12 ◽  
Nitzan Abelson ◽  
Gal Meiri ◽  
Shirley Solomon ◽  
Hagit Flusser ◽  
Analya Michaelovski ◽  

Background: Multiple prenatal factors have been associated with autism spectrum disorder (ASD) risk. However, current data about the association between antimicrobial use during pregnancy and ASD is limited.Methods: A nested matched case-control study of children with ASD (cases), and children without ASD or other psychiatric or genetic disorders (controls). We compared the use of antimicrobial therapy during the 3 months before conception or during pregnancy between mothers of cases and controls and used multivariate conditional logistic regression models to assess the independent association between maternal use of antimicrobials during pregnancy and the risk of ASD in their offspring.Results: More than half of the mothers in the study (54.1%) used antimicrobial drugs during the 3 months before conception or during pregnancy. Rates of antimicrobial use were lower for mothers of children with ASD compared to mothers of controls (49.0 vs. 55.1%, respectively; p = 0.02), especially during the third trimester of pregnancy (18.8 vs. 22.9%, respectively; p = 0.03), and for the use of penicillins (15.7 vs. 19.7%, respectively; p = 0.06). These case–control differences suggest that antimicrobial administration during pregnancy was associated with a reduced risk of ASD in the offspring (aOR = 0.75, 95% CI = 0.61–0.92). Interestingly, this association was seen only among Jewish but not for the Bedouin mothers (aOR = 0.62, 95% CI = 0.48–0.79 and aOR = 1.21, 95% CI = 0.82–1.79).Conclusions: The reduced risk of ASD associated with prenatal antimicrobials use only in the Jewish population suggest the involvement of other ethnic differences in healthcare services utilization in this association.

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