scholarly journals The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Redox Biology ◽  
2021 ◽  
pp. 102076
Author(s):  
Zhijian Jin ◽  
Yifan Lu ◽  
Xiongyan Wu ◽  
Tao Pan ◽  
Zhenjia Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Cells ◽  
Cross Talk ◽  
Acquired Resistance ◽  
Human Gastric Cancer ◽  
The Cross ◽  
Activated Fibroblasts

scholarly journals IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

2018 ◽  
Vol 78 (17) ◽  
pp. 4957-4970 ◽  
Author(s):  
Tatiana A. Karakasheva ◽  
Eric W. Lin ◽  
Qiaosi Tang ◽  
Edmund Qiao ◽  
Todd J. Waldron ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cells ◽  
Cross Talk ◽  
Activated Fibroblasts

scholarly journals A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis

2019 ◽  
Vol 25 (11) ◽  
pp. 3317-3328 ◽  
Author(s):  
Zhijun Zhou ◽  
Guanggai Xia ◽  
Zhen Xiang ◽  
Mingyang Liu ◽  
Zhewei Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Cells ◽  
Chemokine Receptor ◽  
Cross Talk ◽  
Cancer Metastasis ◽  
Receptor Type

scholarly journals The cross talk between long, non-coding RNAs and microRNAs in gastric cancer

2015 ◽  
Vol 48 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Kaiyuan Deng ◽  
Hao Wang ◽  
Xiaoqiang Guo ◽  
Jiazeng Xia
Keyword(s):  
Gastric Cancer ◽  
Cross Talk ◽  
Non Coding Rnas ◽  
The Cross

The Cross Talk Between Protein Kinase A– and RhoA-Mediated Signaling in Cancer Cells

2005 ◽  
Vol 230 (10) ◽  
pp. 731-741 ◽  
Author(s):  
Yongchang Chen ◽  
Ying Wang ◽  
Hao Yu ◽  
Fengwei Wang ◽  
Wenrong Xu
Keyword(s):  
Prostate Cancer ◽  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Cross Talk ◽  
Cancer Cell Line ◽  
Rhoa Activation ◽  
The Cross ◽  
Signal Transductions ◽  
Kinase A

The cross talk between cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and RhoA-mediated signal transductions and the effect of this cross talk on biologic features of human prostate and gastric cancer cells were investigated. In the human gastric cancer cell line, SGC-7901, lysophosphatidic acid (LPA) increased RhoA activity in a dosedependent manner. The cellular permeable cAMP analog, 8-chlorophenylthio-cAMP (CPT-cAMP), inhibited the LPA-induced RhoA activation and caused phosphorylation of RhoA at serine188. Immunofluorescence microscopy, Western blotting, and green fluorescent protein (GFP)-tagged RhoA location assay in live cells revealed that RhoA was distributed in both the cytoplasm and nucleus of SGC-7901 cells. Treatment with LPA and/or CPT-cAMP did not induce obvious translocation of RhoA in the cells. The LPA treatment caused formation of F-actin in SGC-7901 cells, and CPT-cAMP inhibited the formation. In a modified Boyden chamber assay, LPA stimulated the migration of SGC-7901 cells, and CPT-cAMP dose-dependently inhibited the stimulating effect of LPA. In soft agar assay, LPA stimulated early proliferation of SGC-7901 cells, and CPT-cAMP significantly inhibited the growth of LPA-stimulated cells. In the prostate cancer cell line, PC-3, LPA caused morphologic changes from polygonal to round, and transfection with plasmid DNA encoding constitutively active RhoA(63L) caused a similar change. Treatment with CPT-cAMP inhibited the changes in both cases. However, in PC-3 cells transfected with a plasmid encoding mutant RhoA188A, LPA induced rounding, but CPT-cAMP could not prevent the change. Results of this experiment indicated that cAMP/PKA inhibited RhoA activation, and serine188 phosphorylation on RhoA was necessary for PKA to exert its inhibitory effect on RhoA activation. The cross talk between cAMP/PKA and RhoA-mediated signal transductions had significant affect on biologic features of gastric and prostate cancer cells, such as morphologic and cytoskeletal change, migration, and anchorage-independent growth. The results may be helpful in implementing novel therapeutic strategies for invasive and metastatic prostate and gastric cancers.

Isolation and characterization of circulating tumor cells from human gastric cancer patients

2014 ◽  
Vol 141 (4) ◽  
pp. 647-660 ◽  
Author(s):  
Dandan Yuan ◽  
Liang Chen ◽  
Mingxing Li ◽  
Hongwei Xia ◽  
Yuchen Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Human Gastric Cancer ◽  
Isolation And Characterization ◽  
Gastric Cancer Patients

Induction of T Lymphocytes Specific to Human Gastric Cancer Using HLA-A Matched Allogeneic Gastric Tumor Cells

2003 ◽  
Vol 26 (5) ◽  
pp. 403-411 ◽  
Author(s):  
Yongzhan Nie ◽  
Kaichun Wu ◽  
Jinghua Yang ◽  
Fengqi Tian ◽  
Ling Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocytes ◽  
Tumor Cells ◽  
Gastric Tumor ◽  
Human Gastric Cancer
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