scholarly journals Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study

2019 ◽  
Vol 84 ◽  
pp. 32-38 ◽  
Author(s):  
Linda Titus ◽  
Elizabeth E. Hatch ◽  
Keith M. Drake ◽  
Samantha E. Parker ◽  
Marianne Hyer ◽  
...  
Author(s):  
Linda Titus

Abstract This review summarizes key findings from the US National Cancer Institute (NCI) DES Combined Cohort Study with a focus on the results of the NCI Third Generation Study, a cohort of DES-exposed and unexposed granddaughters. Findings to date from the Third Generation Study are discussed in the context of other research efforts and case reports suggesting an intergenerational heritability of DES-related effects. The DES story serves as a model for the influence of endocrine disrupting chemicals on human health. It also serves as a warning of the special hazards of pregnancy exposures, and more broadly, of the potential for invisible health consequences arising from new or changing exposures.


2019 ◽  
pp. 1-12
Author(s):  
Amanda L. Vogel ◽  
Douglas M. Puricelli Perin ◽  
Ya-Ling Lu ◽  
Stephen H. Taplin

PURPOSE International research networks have the potential to accelerate scientific progress via knowledge sharing and collaboration. In 2018, the US National Cancer Institute evaluated the International Cancer Screening Network (ICSN), in operation since 1988. METHODS ICSN hosts a biennial scientific meeting and scientific working groups. A survey was fielded to 665 ICSN participants, and a bibliometric analysis was conducted for ICSN publications. RESULTS A total of 243 individuals completed the survey (36.5%). They reported that participating in the ICSN helped advance their knowledge of cancer screening research (75.7%), policy development (56%), and implementation (47.7%). Approximately three-quarters agreed that ICSN facilitated knowledge sharing and networking among researchers and implementers (79.9%) and those working on different continents (74.0%) and cancer sites (73.7%). More than half reported that participating helped them form new collaborations in screening implementation (58.0%) or research (57.6%). Most agreed that ICSN helped to advance screening research and evaluation (75.4%), effective screening practices (71.2%), and screening policies (60.9%). Many reported that participating informed advances in their own research (68.7%) and screening implementation (50.2%) and policies (49.4%) in their settings. Approximately two-thirds agreed that ICSN helped advance career development among current experts (66.6%) and train the next generation (62.2%). Half (51.4%) reported that participating advanced their own careers. The 20 ICSN publications included 75 coauthors. They were cited in 589 publications with more than 2,000 coauthors. CONCLUSION Findings provide evidence of the influence of ICSN on international knowledge dissemination, collaboration, and advances in cancer screening research, implementation, and policies and highlight the potential value of longstanding international research networks.


1997 ◽  
Vol 72 (10) ◽  
pp. 901-912 ◽  
Author(s):  
John P. Chute ◽  
David J. Venzon ◽  
Lynn Hankins ◽  
Paul Okunieff ◽  
James N. Frame ◽  
...  

2020 ◽  
pp. 1-46
Author(s):  
Janet Currie ◽  
Michael Mueller-Smith ◽  
Maya Rossin-Slater

We study the effects of prenatal exposure to violent crime on infant health, using New York City crime records linked to mothers' addresses in birth records data. We address endogeneity of assault exposure with three strategies and find that in utero assault exposure significantly increases the incidence of adverse birth outcomes. We calculate that the annual social cost of assault during pregnancy in the US is more than $3.8 billion. Since infant health predicts long-term wellbeing and disadvantaged women are disproportionately likely to be domestic abuse victims, violence in utero may be an important channel for intergenerational transmission of inequality.


Oncogene ◽  
2011 ◽  
Vol 31 (4) ◽  
pp. 403-418 ◽  
Author(s):  
G Zoppoli ◽  
S Solier ◽  
W C Reinhold ◽  
H Liu ◽  
J W Connelly ◽  
...  

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