scholarly journals Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad

2022 ◽  
Vol 19 ◽  
pp. 35-46
Author(s):  
Koji Tanimoto ◽  
Taro Matsumoto ◽  
Yuki Nagaoka ◽  
Tomohiko Kazama ◽  
Chii Yamamoto ◽  
...  
Keyword(s):  
Functional Properties ◽  
Infrapatellar Fat Pad ◽  
Fat Cells ◽  
Fat Pad ◽  
Dedifferentiated Fat Cells

scholarly journals The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad

2013 ◽  
Vol 18 (8) ◽  
pp. 1893-1901 ◽  
Author(s):  
Naotaka Kishimoto ◽  
Yoshihiro Momota ◽  
Yoshiya Hashimoto ◽  
Shinichi Tatsumi ◽  
Kayoko Ando ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteoblastic Differentiation ◽  
Adipose Stem Cells ◽  
Fat Cells ◽  
Fat Pad ◽  
Buccal Fat Pad ◽  
Dedifferentiated Fat Cells

scholarly journals Phenotypic and functional properties of feline dedifferentiated fat cells and adipose-derived stem cells

2014 ◽  
Vol 199 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Shota Kono ◽  
Tomohiko Kazama ◽  
Koichiro Kano ◽  
Kayoko Harada ◽  
Masami Uechi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Functional Properties ◽  
Fat Cells ◽  
Adipose Derived Stem Cells ◽  
Dedifferentiated Fat Cells

scholarly journals Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells

2010 ◽  
Vol 43 (5) ◽  
pp. 920-926 ◽  
Author(s):  
Conor Timothy Buckley ◽  
Tatiana Vinardell ◽  
Stephen Desmond Thorpe ◽  
Matthew George Haugh ◽  
Elena Jones ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Functional Properties ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Cartilaginous Tissues

scholarly journals The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yiqin Zhou ◽  
Haobo Li ◽  
Dong Xiang ◽  
Jiahua Shao ◽  
Qiwei Fu ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Knee Arthroscopy ◽  
Infrapatellar Fat Pad ◽  
Control Group ◽  
Knee Cartilage ◽  
Fat Pad ◽  
Group 12 ◽  
Significant Difference

Abstract Introduction To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method. Methods Sixty cases from Shanghai Changzheng Hospital from April 2018 to December 2019 were chosen and randomly divided into 2 groups equally. Patients in the experiment group were treated through knee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stromal cells, while patients in the control group were treated through regular knee arthroscopic therapy. VAS and WOMAC scores were assessed at pre-operation, and 6 weeks, 12 weeks, 6 months, and 12 months after intervention. MORCART scores were assessed at pre-operation and 12 months after intervention. Results Twenty-nine cases in the experiment group and 28 cases in the control group were followed up. No significant difference in VAS, WOMAC, and MOCART scores were found between the two groups before surgery (P > 0.05). The WOMAC total and WOMAC function scores of the experiment group were significantly lower than those of the control group 6 months and 12 months after surgery (P < 0.05). The VAS rest and VAS motion scores of the experiment group were found significantly lower than those of the control group 12 months after surgery (P < 0.05). The MOCART scores of the experiment group were found significantly higher compared with the control group 12 months after surgery (P < 0.05). No significant difference in WOMAC stiffness scores were found between the two groups. Conclusions The short-term results of our study are encouraging and demonstrate that knee arthroscopy with infrapatellar fat pad cell concentrates containing mesenchymal stromal cells is safe and provides assistance in reducing pain and improving function in patients with knee cartilage lesions. Trial registration ChiCTR1800015379. Registered on 27 March 2018, http://www.chictr.org.cn/showproj.aspx?proj=25901.

Hypoxic Preconditioning Induces Neuronal Differentiation of Infrapatellar Fat Pad Stem Cells through Epigenetic Alteration

2021 ◽  
Vol 12 (4) ◽  
pp. 704-718
Author(s):  
Subathra Radhakrishnan ◽  
Catherine Ann Martin ◽  
Geethanjali Dhayanithy ◽  
Mettu Srinivas Reddy ◽  
Mohamed Rela ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neuronal Differentiation ◽  
Hypoxic Preconditioning ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Epigenetic Alteration

scholarly journals FRI0416 COMBINATION OF SERUM ADIPOKINES/RELATED INFLAMMATORY FACTORS AND RATIOS AS PREDICTORS OF INFRAPATELLAR FAT PAD VOLUME IN KNEE OSTEOARTHRITIS PATIENTS: USAGE OF A COMPREHENSIVE MACHINE LEARNING APPROACH

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 806.1-807
Author(s):  
H. Bonakdari ◽  
G. Tardif ◽  
F. Abram ◽  
J. P. Pelletier ◽  
J. Martel-Pelletier
Keyword(s):  
Risk Factors ◽  
Serum Levels ◽  
Infrapatellar Fat Pad ◽  
Inflammatory Factors ◽  
Fat Pad ◽  
Research Support ◽  
Knee Oa ◽  
Total Cohort ◽  
Low Bmi ◽  
The University

Background:One of the hurdles in osteoarthritis (OA) drug discovery and the improvement of therapeutic approaches is the early identification of patients who will progress. It is therefore crucial to find efficient and reliable means of screening OA progressors. Although the main risk factors, age, gender and body mass index (BMI), are important, they alone are poor predictors. However, serum factors could be potential biomarkers for early prediction of knee OA progression.Objectives:In a first step toward finding early reliable predictors of OA progressors, this study aimed to determine, in OA individuals, the optimum combination of serum levels of adipokines/related inflammatory factors, their ratios, and the three main OA risk factors for predicting knee OA infrapatellar fat pad (IPFP) volume, as this tissue has been associated with knee OA onset and progression.Methods:Serum and magnetic resonance images (MRI) were from the Osteoarthritis Initiative at baseline. Variables (48) comprised the 3 main OA risk factors (age, gender, BMI), 6 adipokines, 3 inflammatory factors, and their 36 ratios. IPFP volume was assessed on MRI with a neural network methodology. The best variables and models were identified in Total cohort (n=678), High-BMI (n=341) and Low-BMI (n=337), using an artificial intelligence selection approach: the adaptive neuro-fuzzy inference system embedded with fuzzy c-means clustering (ANFIS-FCM). Performance was validated using uncertainty analyses and statistical indices. Reproducibility was done using 80 OA patients from a clinical trial (female, n=57; male, n=23).Results:For the three groups, 8.44E+14 sub-variables were investigated and 48 models were selected. The best model for each group included five variables: the three risk factors and adipsin/C-reactive protein combined for Total cohort, adipsin/chemerin; High-BMI, chemerin/adiponectin high molecular weight; and Low-BMI, interleukin-8. Data also revealed that the main form of the ratio used for the model was justified, as the use of the inverse form slightly decreased the performance of the model in both training and testing stages. Further investigation indicated that gender improved (13-16%) the prediction results compared to the BMI-based models. For each gender, we then generated a pseudocode (an evolutionary computation equation) with the 5 variables for predicting IPFP volume. Reproducibility experiments were excellent (correlation coefficient: female 0.83, male 0.95).Conclusion:This study demonstrates, for the first time, that the combination of the serum levels of adipokines/inflammatory factors and the three main risk factors of OA could predict IPFP volume with high reproducibility, and superior performance with gender separation. By using the models for each gender and the pseudocodes for OA patients provided in this study, the next step will be to develop a predictive model for OA progressors.Acknowledgments:This work was funded by the Chair in Osteoarthritis of the University of Montreal, the Osteoarthritis Research Unit of the University of Montreal Hospital Research Centre, the Groupe de recherches des maladies rhumatismales du Québec and by ArthroLab Inc., all from Montreal, Quebec, Canada.Disclosure of Interests:Hossein Bonakdari: None declared, Ginette Tardif: None declared, François Abram Employee of: ArthroLab Inc., Jean-Pierre Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica, Speakers bureau: TRB Chemedica and Mylan, Johanne Martel-Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica

scholarly journals Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases

1999 ◽  
Vol 23 (2) ◽  
pp. 114-117 ◽  
Author(s):  
H. Sakai ◽  
K. Tamai ◽  
A. Iwamoto ◽  
K. Saotome
Keyword(s):  
Infrapatellar Fat Pad ◽  
Fat Pad
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