Pectins from various sources inhibit galectin-3-related cardiac fibrosis

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

Download Full-text

Galectin-3 in Patients with Atrial Fibrillation and Restored Sinus Rhythm

Folia Medica ◽

10.3897/folmed.63.e55313 ◽

2021 ◽

Vol 63 (3) ◽

pp. 329-336

Author(s):

Antoniya Kisheva ◽

Yoto Yotov ◽

Trifon Chervenkov ◽

Atanas Angelov ◽

Yana Bocheva

Keyword(s):

Atrial Fibrillation ◽

Sinus Rhythm ◽

Renal Dysfunction ◽

Cardiac Fibrosis ◽

Antihypertensive Drugs ◽

Female Gender ◽

Control Treatment ◽

Atrial Remodeling ◽

Galectin 3 ◽

One Year

Introduction: Cardiac fibrosis is the hallmark of atrial remodeling in atrial fibrillation. Galectin-3 (Gal-3) is a biomarker of fibrosis. It is well studied in heart failure, but the data about its role in atrial fibrillation are sparse.Aim: The aim of the study was to evaluate the levels of Gal-3 in patients with atrial fibrillation after sinus rhythm restoration, to examine the association between this biomarker and other factors for developing atrial fibrillation and to assess its prognostic role.Materials and methods: We included 67 patients (35 male) at the mean age of 67.36±7.25 years, with Gal-3 test after sinus rhythm restoration, a subgroup of participants in placebo-controlled randomized clinical trial of treatment with spironolactone. They were followed up for atrial fibrillation recurrence and hospitalizations. The effect of demographic parameters and other factors on Gal-3 levels were evaluated before and one year after treatment.Results: Mean Gal-3 at baseline was 16.9±6.8 ng/ml. Higher levels of Gal-3 were associated with female gender (р=0.008), increasing age (р=0.005), renal dysfunction (p<0.0001) and gout (р=0.002). Higher thromboembolic risk as assessed by CHA2DS2-VASc score was significantly related to Gal-3. The levels of biomarker did not affect the number of atrial fibrillation recurrences (p=0.9) and hospitalizations. No correlation was found with treatment with spironolactone, antiarrhythmic and antihypertensive drugs.Conclusions: Higher Gal-3 in atrial fibrillation was associated with female sex, renal dysfunction, and history of gout. The levels of Gal-3 were not related to rhythm control. Treatment with spironolactone did not affect the biomarker of fibrosis Gal-3 in AF patients. Higher Gal-3 was related to high embolic risk.

Download Full-text

Abstract 15237: Serum Galectin-3 Level Predicts Late Recurrence Following Cryoballoon-based Pulmonary Vein Isolation in Lone Atrial Fibrillation Patients

Circulation ◽

10.1161/circ.130.suppl_2.15237 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Kadri M Gurses ◽

Muhammed U Yalcin ◽

Duygu Kocyigit ◽

Hande Canpinar ◽

Banu Evranos ◽

...

Keyword(s):

Atrial Fibrillation ◽

Left Atrial ◽

Cardiac Fibrosis ◽

Cox Regression ◽

Independent Predictor ◽

Interstitial Fibrosis ◽

Early Recurrence ◽

Cox Regression Analysis ◽

Galectin 3 ◽

Af Recurrence

BACKGROUND: Left atrial(LA) interstitial fibrosis is known to be a key contributor to atrial fibrillation(AF) development and maintenance. The role of galectin-3 in the pathogenesis of cardiac fibrosis has been demonstrated in previous studies. We aimed to determine whether serum galectin-3 level is an independent predictor for the late AF recurrence in patients with lone AF who underwent cryoballoon- based pulmonary ven isolation(PVI). METHODS: 100 patients (43.80% male, 56.95± 11.36 years) with lone AF who underwent cryoballoon-based PVI were included in the study. Pre-procedural galectin-3 levels were measured with ELISA. RESULTS: At a follow-up of 12 months, 76 (76%) patients were free of late AF recurrence. Body mass index(BMI) ( 25.04± 1.54 vs. 23.93± 2.08 kg/m2, p=0.002), AF duration [7 (3- 20) vs. 5 (1- 24) months, p=0.024], serum galectine-3 levels [11.10 (4.20- 33.80) vs. 5.70 (2.60- 12.40) ng/mL, p<0.001], left atrial diameter(LAD) (4.30± 0.40 vs.3.79± 0.42 cm, p<0.001) and incidence of early recurrence (60 vs 2%, p<0.001) were found to be significantly higher in patients with late AF recurrence. Serum galectin-3 levels (HR: 1.16, p<0.001), LAD (HR: 3.38, p= 0.042) and early recurrence (HR: 10.92, p<0.001) were found to be independent predictors of late AF recurrence in the multivariate Cox regression analysis. A cut-off level for serum galectin-3 level of 7.9 ng/mL predicted late AF recurrence in lone AF patients with a sensitivity of 93.33% and specificity of 87.76% (AUC: 0.910, p<0.001). CONCLUSION: Pre-procedural serum galectin-3 level is an independent predictor of late AF recurrence following cryoballoon-based PVI in patients with lone AF. Galectin-3 may serve as a novel biomarker to identify patients with high recurrence risk following AF ablation.

Download Full-text

Evolution of the slopes of ST2 and galectin-3 during marathon and ultratrail running compared to a control group

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2019-0555 ◽

2020 ◽

Vol 58 (2) ◽

pp. 314-321

Author(s):

Caroline Le Goff ◽

Jean-François Kaux ◽

Jordi Farre Segura ◽

Violeta Stojkovic ◽

Arnaud Ancion ◽

...

Keyword(s):

Recovery Time ◽

Cardiac Fibrosis ◽

Cardiac Biomarkers ◽

Control Group ◽

Cardiac Damage ◽

Marathon Runners ◽

Significant Difference ◽

Before And After ◽

Galectin 3 ◽

Recreational Runners

AbstractBackgroundPrevious studies have suggested that exercising may induce cardiac damage. Galectin-3 (Gal-3) and soluble suppression of tumorigenicity 2 (ST2) are very interesting biomarkers for heart failure and myocardial fibrosis. We aimed to compare the kinetics of emerging fibrosis cardiac biomarkers as Gal-3 and ST-2 in endurance runners, and recreational runners before and after a running event represented by a marathon and an ultratrail event.MethodsBlood samples were taken from 19 healthy non-elite marathon runners (42 km), 27 ultratour runners (67 km), and 14 recreational runners who represented the control group (10 km) just before the run (T0), just after (T1) and 3 h after (T2), in order to analyze Gal-3, ST2, hsTnT, NT-proBNP, CKMB and hsCRP. We compared the percentage of evolution and the slopes obtained from T0 to T1 (pT0T1) and from T1 to T2 (pT1T2), between the different groups of runners participating in three different races.ResultsPlasma cardiac biomarker concentrations increased significantly from baseline to immediately post-exercise and most of the time decreased over the subsequent 3-h period. For pT0T1 and pT1T2, the markers Gal-3 and ST2 showed a significant difference between types of run (p < 0.05 and p < 0.0001, respectively). During the recovery time, Gal-3 returned to the baseline values but not ST2 which continued to increase.ConclusionsGal-3 and ST2 are considered as a reflection of cardiac fibrosis and remodeling. The evolution of both was different, particularly after the recovery time. ST2 values exceeding cutoff values at any time.

Download Full-text

Amperometric galectin-3 immunosensor-based gold nanoparticle-functionalized graphitic carbon nitride nanosheets and core–shell Ti-MOF@COFs composites

Nanoscale ◽

10.1039/d0nr05614f ◽

2020 ◽

Vol 12 (38) ◽

pp. 19824-19832 ◽

Cited By ~ 1

Author(s):

Mehmet Lütfi Yola ◽

Necip Atar

Keyword(s):

Heart Failure ◽

Gold Nanoparticle ◽

Carbon Nitride ◽

Cardiac Fibrosis ◽

Graphitic Carbon Nitride ◽

Core Shell ◽

Death Risk ◽

Failure Risk ◽

Galectin 3 ◽

Carbon Nitride Nanosheets

Antigen galectin-3 (GL-3), a member of β-galactoside proteins indicates cardiac fibrosis and is a significant biomarker for monitoring heart failure risk and death risk.

Download Full-text

LBOS 02-03 THE INFILTRATING MACROPHAGE-SECRETED GALECTIN-3 PLAYS AN ESSENTIAL ROLE IN CARDIAC FIBROSIS AND DIASTOLIC FUNCTION IN MURINE PRESSURE-OVERLOAD MODEL

Journal of Hypertension ◽

10.1097/01.hjh.0000501503.60171.8b ◽

2016 ◽

Vol 34 (Supplement 1) ◽

pp. e549 ◽

Cited By ~ 2

Author(s):

Jin-jer Chen ◽

Wen-Rui Hao ◽

Kuan-Cheng Chang ◽

Ju-Chi Liu

Keyword(s):

Diastolic Function ◽

Essential Role ◽

Cardiac Fibrosis ◽

Pressure Overload ◽

Galectin 3

Download Full-text

Lack of Galectin-3 Prevents Cardiac Fibrosis and Effective Immune Responses in a Murine Model ofTrypanosoma cruziInfection

The Journal of Infectious Diseases ◽

10.1093/infdis/jiv185 ◽

2015 ◽

Vol 212 (7) ◽

pp. 1160-1171 ◽

Cited By ~ 22

Author(s):

Miguel A. Pineda ◽

Henar Cuervo ◽

Manuel Fresno ◽

Manuel Soto ◽

Pedro Bonay

Keyword(s):

Immune Responses ◽

Murine Model ◽

Cardiac Fibrosis ◽

Galectin 3

Download Full-text

The concentration of high-sensitivity troponin I, galectin-3 and NT-proBNP substantially increase after a 60-km ultramarathon

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2013-0601 ◽

2014 ◽

Vol 52 (2) ◽

Cited By ~ 19

Author(s):

Gian Luca Salvagno ◽

Federico Schena ◽

Matteo Gelati ◽

Elisa Danese ◽

Gianfranco Cervellin ◽

...

Keyword(s):

Endurance Exercise ◽

High Intensity ◽

Cardiac Fibrosis ◽

Troponin I ◽

High Sensitivity ◽

High Sensitivity Troponin ◽

Diagnostic Threshold ◽

Galectin 3 ◽

Study Population ◽

Amount Of Knowledge

AbstractThe leading mechanisms responsible for the most prevalent and serious cardiac injuries include myocardiocyte stretch, myocardiocyte necrosis and cardiac fibrosis, which can now be reliably mirrored by measurement of natriuretic peptides, cardiospecific troponins and galectin-3, respectively. Although a large amount of knowledge has been gathered about the behavior and clinical significance of these biomarkers in patients with cardiac disorders, less information is available on their biology in paraphysiological conditions, including high-intensity endurance exercise.The study population consisted of 18 trained athletes, who performed a 60-km ultramarathon run. Blood was collected before the run (i.e., “baseline”) and immediately after the end of the ultramarathon (“post-marathon”) for measurement of serum high-sensitivity troponin I (TnI), NT-proBNP and galectin-3.The concentration of all biomarkers measured in the post-marathon samples was remarkably increased as compared with the values obtained on baseline specimens. In particular, the median increase was 3.3 for TnI, 3.5 for NT-proBNP and 2.4 for galectin-3, respectively. The frequency of values exceeding the diagnostic threshold did not differ at baseline and after the ultramarathon for TnI (6% vs. 25%; p=0.15), instead was significantly increased for NT-proBNP (0% vs. 28%; p=0.016) and galectin-3 (0% vs. 67%; p<0.001). No significant correlation was found among the increase of any of the three biomarkers.The results of this study demonstrate that high-intensity endurance exercise is associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure and biology.

Download Full-text