Numerical Study of Circularly Slotted Highly Sensitive Plasmonic Biosensor: A Novel Approach

In this paper, a racetrack ring resonator design based on a subwavelength grating double slot waveguide is presented. The proposed waveguide scheme is capable of confining the transverse electric field in the slots and the gaps between the grating segments. This configuration facilitates a large light–matter interaction which elevates the sensitivity of the device approximately 2.5 times higher than the one that can be obtained via a standard slot waveguide resonator. The best sensitivity of the design is obtained at 1000 nm/RIU by utilizing a subwavelength grating double slot waveguide of period 300 nm. The numerical study is conducted via 2D and 3D finite element methods. We believe that the proposed sensor design can play an important role in the realization of highly sensitive lab-on-chip sensors.

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A novel approach to detect KRAS/BRAF mutation for colon cancer: Highly sensitive simultaneous detection of mutations and simple pre-treatment without DNA extraction

International Journal of Oncology ◽

10.3892/ijo.2015.2978 ◽

2015 ◽

Vol 47 (1) ◽

pp. 97-105 ◽

Cited By ~ 3

Author(s):

SHUN-ICHI SUZUKI ◽

SATOSHI MATSUSAKA ◽

MITSUHARU HIRAI ◽

HARUMI SHIBATA ◽

KOICHI TAKAGI ◽

...

Keyword(s):

Colon Cancer ◽

Dna Extraction ◽

Braf Mutation ◽

Simultaneous Detection ◽

Novel Approach ◽

Highly Sensitive ◽

Pre Treatment ◽

Detection Of Mutations

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Numerical study of magnetic particles mixing in waste water under an external magnetic field

Journal of Water Supply Research and Technology—AQUA ◽

10.2166/aqua.2020.090 ◽

2020 ◽

Vol 69 (3) ◽

pp. 266-275 ◽

Cited By ~ 4

Author(s):

Christos Liosis ◽

Evangelos G. Karvelas ◽

Theodoros Karakasidis ◽

Ioannis E. Sarris

Keyword(s):

Magnetic Field ◽

Magnetic Particles ◽

Numerical Study ◽

Low Frequency ◽

Water And Wastewater Treatment ◽

Novel Approach ◽

Optimal Value ◽

Frequency Optimum ◽

Combined Action ◽

Aligned Magnetic Field

Abstract The combination of nanotechnology and microfluidics may offer an effective water and wastewater treatment. A novel approach combines the use of magnetic particles which can capture heavy metal impurities in microfluidic ducts. The purpose of this study is to investigate the mixing mechanism of two water streams, one with magnetic particles and the other with wastewater. The optimum mixing is obtained when particles are uniformly distributed along the volume of water in the duct for the combined action of a permanent, spatially and temporally aligned magnetic field. Results showed that mixing is enhanced as the frequency of the magnetic field decreases or its amplitude increases, while magnetic gradient is found to play an insignificant role in the present configuration. Moreover, for simulations with low frequency, the mean concentration of particles is found to be twice as high as compared to the cases with higher frequency. Optimum distribution of particles inside the micromixer is observed for the combination of 0.6 T, 8 T/m and 5 Hz for the magnetic magnitude, gradient and frequency, respectively, where concentration reaches the optimal value of 0.77 mg/mL along the volume of the duct.

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Robust Visual Tracking Based on Fusional Multi-Correlation-Filters with a High-Confidence Judgement Mechanism

Applied Sciences ◽

10.3390/app10062151 ◽

2020 ◽

Vol 10 (6) ◽

pp. 2151

Author(s):

Wenbin Wang ◽

Chao Liu ◽

Bo Xu ◽

Long Li ◽

Wei Chen ◽

...

Keyword(s):

Time Frame ◽

Spatial Layout ◽

Motion Blur ◽

Frame Rate ◽

Visual Object ◽

Correlation Filters ◽

High Confidence ◽

Novel Approach ◽

Highly Sensitive ◽

Fast Motion

Visual object trackers based on correlation filters have recently demonstrated substantial robustness to challenging conditions with variations in illumination and motion blur. Nonetheless, the models depend strongly on the spatial layout and are highly sensitive to deformation, scale, and occlusion. As presented and discussed in this paper, the colour attributes are combined due to their complementary characteristics to handle variations in shape well. In addition, a novel approach for robust scale estimation is proposed for mitigatinge the problems caused by fast motion and scale variations. Moreover, feedback from high-confidence tracking results was also utilized to prevent model corruption. The evaluation results for our tracker demonstrate that it performed outstandingly in terms of both precision and accuracy with enhancements of approximately 25% and 49%, respectively, in authoritative benchmarks compared to those for other popular correlation- filter-based trackers. Finally, the proposed tracker has demonstrated strong robustness, which has enabled online object tracking under various scenarios at a real-time frame rate of approximately 65 frames per second (FPS).

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MODAL TRIGGERED NONLINEARITIES FOR DAMAGE LOCALIZATION IN THIN WALLED FRC STRUCTURES – A NUMERICAL STUDY

Facta Universitatis Series Mechanical Engineering ◽

10.22190/fume1601021r ◽

2016 ◽

Vol 14 (1) ◽

pp. 21 ◽

Cited By ~ 5

Author(s):

Tobias Rademacher ◽

Manfred Zehn

Keyword(s):

Numerical Study ◽

Fem Simulation ◽

Harmonic Distortion ◽

Mode Shapes ◽

Novel Approach ◽

Simulation Based ◽

Novel Method ◽

Thin Walled ◽

Modal Description ◽

Nonlinear Measure

This paper presents a novel method for detecting locations of damages in thin walled structural components made of fiber reinforced composites (FRC). Therefore, the change of harmonic distortion, which is found by current research to be very sensitive to delamination, under resonant excitation will be derived from FEM-simulation. Based on the linear modal description of the undamaged structure and the damage-induced nonlinearities represented by a nonlinear measure, two spatial damage indexes have been formulated.The main advantage of this novel approach is that the information about the defect is represented mainly by changes in the modal harmonic distortion (MHD), which just needs to be measured in one (or few) structural points. The spatial resolution is given by the pairwise coupling of the MHD with the corresponding mode shapes.

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Design and evaluation of split-ring resonators for aptamer-based biosensors

Journal of Sensors and Sensor Systems ◽

10.5194/jsss-7-101-2018 ◽

2018 ◽

Vol 7 (1) ◽

pp. 101-111 ◽

Cited By ~ 6

Author(s):

Tobias Reinecke ◽

Johanna-Gabriela Walter ◽

Tim Kobelt ◽

André Ahrens ◽

Thomas Scheper ◽

...

Keyword(s):

Resonance Frequency ◽

Split Ring Resonator ◽

Target Protein ◽

Ring Resonators ◽

Split Ring ◽

Split Ring Resonators ◽

Molecular Binding ◽

Novel Approach ◽

Highly Sensitive ◽

Line Theory

Abstract. Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.

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Numerical Study of Rectangular Air-Holes Based Highly Dispersion Compensating Octagonal Photonic Crystal Fiber: A Novel Approach

2020 11th International Conference on Computing, Communication and Networking Technologies (ICCCNT) ◽

10.1109/icccnt49239.2020.9225655 ◽

2020 ◽

Author(s):

Delwar Hossain Himel ◽

Md. Mostafa Faruk ◽

Shovasis Kumar Biswas

Keyword(s):

Photonic Crystal ◽

Photonic Crystal Fiber ◽

Numerical Study ◽

Crystal Fiber ◽

Novel Approach

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EV-Associated miRNAs from Peritoneal Lavage are a Source of Biomarkers in Endometrial Cancer

Cancers ◽

10.3390/cancers11060839 ◽

2019 ◽

Vol 11 (6) ◽

pp. 839 ◽

Cited By ~ 8

Author(s):

Berta Roman-Canal ◽

Cristian Pablo Moiola ◽

Sònia Gatius ◽

Sarah Bonnin ◽

Maria Ruiz-Miró ◽

...

Keyword(s):

Endometrial Cancer ◽

Operating Characteristic ◽

Peritoneal Lavage ◽

Characteristic Curve ◽

Unmet Need ◽

Classification Performance ◽

Novel Approach ◽

Highly Sensitive ◽

Aggressive Histology ◽

Mirna Content

Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is responsible for more than 89,000 deaths every year. Mortality is associated with presence of poor prognostic factors at diagnosis, i.e., diagnosis at an advanced stage, with a high grade and/or an aggressive histology. Development of novel approaches that would permit us to improve the clinical management of EC patients is an unmet need. In this study, we investigate a novel approach to identify highly sensitive and specific biomarkers of EC using extracellular vesicles (EVs) isolated from the peritoneal lavage of EC patients. EVs of peritoneal lavages of 25 EC patients were isolated and their miRNA content was compared with miRNAs of EVs isolated from the ascitic fluid of 25 control patients. Expression of the EV-associated miRNAs was measured using the Taqman OpenArray technology that allowed us to detect 371 miRNAs. The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA-383-5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. This finding opens an avenue for the use of EV-associated miRNAs of peritoneal lavages as an untapped source of biomarkers for EC.

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