A wearable self-powered biosensor system integrated with diaper for detecting the urine glucose of diabetic patients

2021 ◽  
Vol 341 ◽  
pp. 130046
Author(s):  
Jiru Zhang ◽  
Jian Liu ◽  
Hang Su ◽  
Fengyun Sun ◽  
Zipeng Lu ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Urine Glucose ◽  
Biosensor System ◽  
Self Powered

scholarly journals Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Energies ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 825 ◽  
Author(s):  
Gymama Slaughter ◽  
Tanmay Kulkarni
Keyword(s):  
Human Plasma ◽  
Power Density ◽  
Plasma Glucose ◽  
Cell Voltage ◽  
Glucose Biosensor ◽  
Biofuel Cell ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
External Power Source ◽  
Self Powered

This work presents the characterization of a self-powered glucose biosensor using individual sequential assays of human plasma glucose obtained from diabetic patients. The self-powered glucose biosensor is exploited to optimize the assay parameters for sensing plasma glucose levels. In particular, the biofuel cell component of the system at pH 7.4, 37 °C generates a power density directly proportional to plasma glucose and exhibited a maximum power density of 0.462 mW·cm−2 at a cell voltage of 0.213 V in 5 mM plasma glucose. Plasma glucose is further sensed by monitoring the charge/discharge frequency (Hz) of the integrated capacitor functioning as the transducer. With this method, the plasma glucose is quantitatively detected in 100 microliters of human plasma with unprecedented sensitivity, as high as 104.51 ± 0.7 Hz·mM−1·cm−2 and a detection limit of 2.31 ± 0.3 mM. The results suggest the possibility to sense human plasma glucose at clinically relevant concentrations without the use of an external power source.

scholarly journals Label-Free Colorimetric Detection of Urine Glucose Based on Color Fading Using Smartphone Ambient-Light Sensor

Chemosensors ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
Wang ◽  
Guo ◽  
Hu ◽  
Liang ◽  
Li ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Colorimetric Assay ◽  
Point Of Care ◽  
Colorimetric Detection ◽  
Diabetic Patients ◽  
Ambient Light ◽  
Label Free ◽  
Urine Glucose ◽  
Light Sensor

In this work, a label-free colorimetric assay was developed for the determination of urine glucose using smartphone ambient-light sensor (ALS). Using horseradish peroxidase—hydrogen peroxide—3,3′,5,5′-tetramethylbenzidine (HRP-H2O2-TMB) colored system, quantitative H2O2 was added to samples to-be-determined for deepest color. The presence of glucose oxidase in urine led to the formation of H2O2 and the reduction of TMBred. As a result of this, the color of the urine faded and the solution changed from deep blue to light blue. We measured the illuminance of the transmitted light by a smartphone ambient light sensor, and thereby color changes were used to calculate the content of urine glucose. After method validation, this colorimetric assay was practically applied for the determination of urine samples from diabetic patients. Good linearity was obtained in the range of 0.039–10.000 mg/mL (R2 = 0.998), and a limit of detection was 0.005 mg/mL. Our method was had high accuracy, sensitivity, simplicity, rapidity, and visualization, providing a new sensor to be potentially applicable for point-of-care detection of urine glucose.

Urine Glucose Tests for Diabetic Patients with Impaired Vision

Diabetes Care ◽  
1978 ◽  
Vol 1 (1) ◽  
pp. 14-17
Author(s):  
A. H. Free ◽  
H. M. Free
Keyword(s):  
Diabetic Patients ◽  
Impaired Vision ◽  
Urine Glucose

Evaluation of Diabetic Patients' Home Urine Glucose Testing Technique and Ability to Interpret Results

1992 ◽  
Vol 18 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Janice L. Smolowitz ◽  
Andrea Zaldivar
Keyword(s):  
Glucose Monitoring ◽  
Package Insert ◽  
Blood Glucose Monitoring ◽  
Diabetic Patients ◽  
Test Results ◽  
Testing Technique ◽  
Urine Glucose ◽  
Glucose Testing ◽  
Urine Testing ◽  
At Home

The attention of diabetes educators has focused on home blood glucose monitoring, with little attention being given to the educational needs of patients who choose to perform home urine glucose monitoring. This study assessed patients' urine glucose testing technique and ability to interpret test results. A questionnaire was developed and administered by clinic nurses to 100 adults with diabetes who perform home urine glucose monitoring. Patients selected the urine testing product they used at home and demonstrated the technique using a prepared glucose solution. The nurse recorded whether patients correctly performed each step in the procedure according to product instructions. Results indicated that 61 % of patients did not perform the procedure correctly. Patients had difficulty reading package insert instructions, could not correctly read a clock, did not wait the correct amount of time before reading test results, and did not routinely keep written result diaries. This study demonstrates the importance of routine review of home urine glucose testing with the product used at home.

scholarly journals A Portable and Flexible Self-Powered Multifunctional Sensor for Real-Time Monitoring in Swimming

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 147
Author(s):  
Yupeng Mao ◽  
Yongsheng Zhu ◽  
Tianming Zhao ◽  
Changjun Jia ◽  
Meiyue Bian ◽  
...  
Keyword(s):  
Real Time ◽  
Nanowire Arrays ◽  
Real Time Monitoring ◽  
Actual Application ◽  
Biosensor System ◽  
External Power ◽  
Constant Output ◽  
Self Powered ◽  
Multifunctional Sensor

A portable and flexible self-powered biosensor based on ZnO nanowire arrays (ZnO NWs) and flexible PET substrate has been designed and fabricated for real-time monitoring in swimming. Based on the piezoelectric effect of polar ZnO NWs, the fabricated biosensor can work in both air and water without any external power supply. In addition, the biosensor can be easily attached to the surface of the skin to precisely monitor the motion state such as joint moving angle and frequency during swimming. The constant output piezoelectric signal in different relative humidity levels enables actual application in different sports, including swimming. Therefore, the biosensor can be utilized to monitor swimming strokes by attaching it on the surface of the skin. Finally, a wireless transmitting application is demonstrated by implanting the biosensor in vivo to detect angiogenesis. This portable and flexible self-powered biosensor system exhibits broad application prospects in sport monitoring, human–computer interaction and wireless sport big data.

scholarly journals Self-Powered Diaper Sensor with Wireless Transmitter Powered by Paper-Based Biofuel Cell with Urine Glucose as Fuel

ACS Sensors ◽  
2021 ◽  
Author(s):  
Isao Shitanda ◽  
Yuki Fujimura ◽  
Tatsuya Takarada ◽  
Ryo Suzuki ◽  
Tatsuo Aikawa ◽  
...  
Keyword(s):  
Biofuel Cell ◽  
Urine Glucose ◽  
Wireless Transmitter ◽  
Self Powered

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

A Comparison Between Sterological Point Counting and Digitizing Tablets

1985 ◽  
Vol 43 ◽  
pp. 666-667
Author(s):  
John M. Basgen ◽  
Eileen N. Ellis ◽  
S. Michael Mauer ◽  
Michael W. Steffes
Keyword(s):  
Electron Microscopy ◽  
Kidney Tissue ◽  
Volume Density ◽  
Diabetic Patients ◽  
Normal Kidney ◽  
Point Counting ◽  
Normal Kidney Tissue ◽  
Biopsy Specimens ◽  
Mitochondrial Volume ◽  
Kidney Lesions

To determine the efficiency of methods of quantitation of the volume density of components within kidney biopsies, techniques involving a semi-automatic digitizing tablet and stereological point counting were compared.Volume density (Vv) is a parameter reflecting the volume of a component to the volume that contains the component, e.g., the fraction of cell volume that is made up of mitochondrial volume. The units of Vv are μm3 /μm3.Kidney biopsies from 15 patients were used. Five were donor biopsies performed at the time of kidney transplantation (patients 1-5, TABLE 1) and were considered normal kidney tissue. The remaining biopsies were obtained from diabetic patients with a spectrum of diabetic kidney lesions. The biopsy specimens were fixed and embedded according to routine electron microscogy protocols. Three glomeruli from each patient were selected randomly for electron microscopy. An average of 12 unbiased and systematic micrographs were obtained from each glomerulus and printed at a final magnification of x18,000.

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