Correlation of end plate shape on MRI and disc degeneration in surgically treated patients with degenerative disc disease and herniated nucleus pulposus

ABSTRACT Objective: To define histological scores for intervertebral disc degeneration that would enable the definition of morphological characteristics of disease, besides improving knowledge of the lumbar degenerative disc disease by means of immunohistochemical markers. Methods: Hematoxylin and Eosin, Alcian/PAS, Masson Trichrome and Safranin O/FCF staining was used on the intervertebral disc degeneration sections of patients with lumbar degenerative disc disease. The protein markers defined in immunohistochemistry were cell proliferation (Ki-67) and apoptosis (p53). Results: The study data enabled the determination of Safranin O/FCF stain as the most effective one for evaluating parameters such as area, diameter, and number of chondrocyte clusters. The importance of using stains in association, such as Safranin O/FCF, Masson Trichrome, Alcian/PAS and Hematoxylin and Eosin, was also determined, as they are complementary for the histopathological verification of intervertebral disc degeneration. By expressing proteins using the immunohistochemistry technique, it was possible to consider two stages of disc degeneration: cell proliferation with chondrocyte cluster formation, and induction of apoptosis. Conclusion: This study enabled the histological and immunohistochemical characterization to be determined for lumbar degenerative disc disease, and its degrees of evolution, by determining new disc degeneration scores.

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RETROSPECTIVE DATA REVIEW TO FIND THE ASSOCIATION OF LUMBOSACRAL TRANSITIONAL VERTEBRA AND DEGENERATIVE DISC DISEASE IN YOUNG PATIENTS

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v70i6.3997 ◽

2020 ◽

Vol 70 (6) ◽

pp. 1734-39

Author(s):

Nadia Gul ◽

Khalid Mehmood ◽

Muhammad Ikram

Keyword(s):

Disc Degeneration ◽

Degenerative Disc Disease ◽

Lumbar Disc ◽

Statistical Significance ◽

Young Patients ◽

P Value ◽

Disc Disease ◽

Degenerative Disc ◽

Transitional Vertebra ◽

Lumbosacral Transitional Vertebra

Objective: To find out the frequency of lumbar disc degeneration among the patients having lumbosacraltransitional vertebra between 20-40 years. Study Design: Retrospective cross sectional study. Place and Duration of Study: Radiology department POF Wah Cantt, from Jan 2018 to Dec 2019. Methodology: Six Hundred patients between 20-40 years having lumbosacral transitional vertebra and historyof low back pain >1 year were studied. X ray and MRI lumbar spine of these patients was studied retrospectivelyon PACS. Two hundred patients having history of traumatic or other non-traumatic etiologies, in addition toLumbosacral transitional vertebra were excluded. Four hundred patients with only lumbosacral transitionalvertebra were included. Data analysis was done by SPSS-22. Castellvi types of transitional vertebra was calculated among patients with degenerative lumbar disc. Results: One hundred and four (26.6%) were having degenerative disc disease while 296 (74.4%) patients werenot having degenerative disc disease. Patients having degenerative disc disease were between 24-40 years withthe mean age 29.96 ± 0.417 years. Among the patients having degenerative disc disease were 59 women and45 males but no statistical significance association was found between gender and degenerative disc disease with p-value = 0.55. Castellvi type III had significant association with degenerative disc disease, p-value = 0.006. Conclusion: Age related disc degeneration is commonly seen in middle age people but in younger age group in2nd and 3rd decade it is observed frequently in those patients having lumbosacral transitional vertebra especially in the setting of no other associated traumatic or non-traumatic etiology, which leads to early degenerative disc disease.

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Replacing the Nucleus Pulposus for Degenerative Disc Disease and Disc Herniation: Disc Preservation Following Discectomy

Handbook of Spine Technology ◽

10.1007/978-3-319-33037-2_94-1 ◽

2019 ◽

pp. 1-20

Author(s):

Uphar Chamoli ◽

Maurice Lam ◽

Ashish D. Diwan

Keyword(s):

Nucleus Pulposus ◽

Disc Herniation ◽

Degenerative Disc Disease ◽

Disc Disease ◽

Degenerative Disc

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Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management

Advances in Orthopedics ◽

10.1155/2012/970752 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 48

Author(s):

Fadi Taher ◽

David Essig ◽

Darren R. Lebl ◽

Alexander P. Hughes ◽

Andrew A. Sama ◽

...

Keyword(s):

Disc Degeneration ◽

Degenerative Disc Disease ◽

Lumbar Disc ◽

Symptomatic Relief ◽

Treatment Options ◽

Treatment Strategies ◽

Lumbar Disc Degeneration ◽

Disc Disease ◽

Degenerative Disc ◽

Novel Treatment

Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine, but novel treatment strategies involving stem cells, growth factors, and gene therapy have the theoretical potential to prevent, slow, or even reverse disc degeneration. Understanding the pathophysiological basis of disc degeneration is essential for the development of treatment strategies that target the underlying mechanisms of disc degeneration rather than the downstream symptom of pain. Such strategies ideally aim to induce disc regeneration or to replace the degenerated disc. However, at present, treatment options for degenerative disc disease remain suboptimal, and development and outcomes of novel treatment options currently have to be considered unpredictable.

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