Simultaneous determination of sulfamonomethoxine, sulfadimethoxine, and their hydroxy/-acetyl metabolites with gradient liquid chromatography in chicken plasma, tissues, and eggs

Talanta ◽  
2005 ◽  
Vol 67 (1) ◽  
pp. 54-58 ◽  
Author(s):  
K KISHIDA ◽  
N FURUSAWA
Keyword(s):  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Gradient Liquid Chromatography

pH-Gradient Liquid Chromatography: Fundamentals and Examples

2017 ◽  
Vol 100 (6) ◽  
pp. 1590-1598 ◽  
Author(s):  
Łukasz Kubik ◽  
Paweł Wiczling ◽  
Roman Kaliszan
Keyword(s):  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Gradient Elution ◽  
Complex Mixtures ◽  
Ph Gradient ◽  
Organic Modifier ◽  
Ph Gradient Elution ◽  
Gradient Separation ◽  
Gradient Liquid Chromatography

Abstract In this paper, we acquaint the readers with the fundamentals of gradient separation, followed by the latest innovations in this field. We describe the principles of organic modifier- and pH-gradient elution emphasizing the differences and similarities with isocratic separation. The double organic modifier-/pH-gradient is also thoroughly reviewed as a useful method for the simultaneous determination of logkw (substitute of logP) and the pka of analytes present in complex mixtures.

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