A meta-analysis of the effects of Vitamin E supplementation on the incidence of retained foetal membranes in dairy cows

2007 ◽  
Vol 67 (3) ◽  
pp. 494-501 ◽  
Author(s):  
N. Bourne ◽  
R. Laven ◽  
D.C. Wathes ◽  
T. Martinez ◽  
M. McGowan
Keyword(s):  
Vitamin E ◽  
Dairy Cows ◽  
Meta Analysis ◽  
Foetal Membranes ◽  
Vitamin E Supplementation

Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Author(s):  
Huikai Miao ◽  
Rongzhen Li ◽  
Dongni Chen ◽  
Jia Hu ◽  
Youfang Chen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Peripheral Neuropathy ◽  
Randomized Controlled Trials ◽  
Lower Incidence ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Modest Improvement ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Vitamin E Supplementation

Abstract Background Chemotherapy often causes chemotherapy-induced peripheral neuropathy (CIPN), but effective prevention measures are still lacking. Whether vitamin E can prevent peripheral neurotoxicity caused by chemotherapy is inconclusive. Therefore, we collected related randomized controlled trials (RCTs) and conducted a meta-analysis to examine whether vitamin E could prevent CIPN. Methods We searched PubMed, EMBASE and the Cochrane databases in November 2019 for eligible trials. Two reviewers conducted the analysis independently when studies were homogeneous enough. Results Eight RCTs, involving 555 patients, were identified. Upon pooling these RCTs, patients who received vitamin E supplementation of 600 mg/day had a significantly lower incidence of peripheral neuropathy (RR 0.31; 95% CI 0.14 to 0.65; P = 0.002) induced by chemotherapy compared with the placebo group. Vitamin E played a key role in decreasing the incidence of peripheral neuropathy in the cisplatin chemotherapy group (RR 0.28; 95% CI 0.14 to 0.54; P = 0.0001). With regard to improvements in sural amplitude, vitamin E supplementation significantly decreased patients’ sural amplitude after three rounds of chemotherapy (RR -2.66; 95% CI -5.09 to -0.24; P =0.03) in contrast with that of placebo supplementation, while no significant difference was observed when patients were treated with vitamin E after six rounds of chemotherapy. In addition, the vitamin E group had better improvement in the neurotoxicity score (RR -2.65; 95% CI -4.01to -1.29; P = 0.0001) and a lower incidence of reflexes and distal paraesthesias (RR 0.50; 95% CI 0.29 to 0.87; P = 0.01) compared to the control group. Conclusion Available data included in this meta-analysis showed that vitamin E supplementation can confer modest improvement in the prevention of CIPN. However, large-scale, well-designed RCTs are needed to confirm the exact role of vitamin E supplementation in the prevention of CIPN.

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 ◽  
Vol 14 (5) ◽  
pp. 17 ◽  
Author(s):  
E.R. Miller ◽  
R. Pastor-Barriuso ◽  
D. Dalal ◽  
R.A. Riemersma ◽  
L.J. Appel ◽  
...  
Keyword(s):  
Vitamin E ◽  
Meta Analysis ◽  
All Cause Mortality ◽  
Vitamin E Supplementation

A systematic review and meta-analysis on the impact of oral vitamin E supplementation on apolipoproteins A1 and B100

2021 ◽  
Author(s):  
Fateme Hamedi Kalajahi ◽  
Meysam Zarezadeh ◽  
Azadeh Dehghani ◽  
Vali Musazadeh ◽  
Ahmadreza Kolahi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin E ◽  
Meta Analysis ◽  
Oral Vitamin ◽  
The Impact ◽  
Vitamin E Supplementation

Effect of Vitamin E Supplementation on Plasma and Urine Levels of Isoprostane F2α in Randomized Controlled Clinical Trials: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 87 (5-6) ◽  
pp. 314-321 ◽  
Author(s):  
Esmaeil Yousefi Rad ◽  
Ebrahim Falahi ◽  
Mahmoud Djalali ◽  
Amir Abbasnezhad ◽  
Mehdi Birjandi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Clinical Trials ◽  
Vitamin E ◽  
Plasma Level ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Urine Level ◽  
Urine Levels ◽  
Vitamin E Supplementation

Abstract. Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and plasma levels of isoprostanes. However, effects of vitamin E supplementation on plasma and urine level of isoprostane F2α as markers of lipid peroxidation were conflicting in various clinical trials. The current meta-analysis was carried out to determine the effects of vitamin E supplementation on plasma and urine levels of isoprostanes F2α in randomized clinical trials. A systematic search of RCTs was carried out in PubMed, Scopus, Science Direct and Cochrane Library databases. OF 889 relevantly founded articles, only four articles with five arms met the criteria for meta-analysis of plasma level of isoprostanes F2α. For the urine level of isoprostane F2α, three studies with 14 arms were included in the meta-analysis. After pooled analyzing, a significant reduction of 6.98 ng / l was seen in plasma level of isoprostane F2α in vitamin E receiving group (95% CI = -11.2, -2.76; P < 0.001) while no significant heterogeneity was seen between the studies included in this meta-analysis (P = 0.81 and I2 = 0.0%). However, the pooled effect of vitamin E supplementation on urine level of isoprostane F2α was not statistically significant (-11.31 pg / mg creatinine (95% CI = -26.4, 3.78; P = 0.88). Results of this meta-analysis have shown that vitamin E supplementation can only reduce plasma level of isoprostane F2α and has no significant effect on reducing urine level of this biomarker.

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