Effect of Sodium Selenite and Vitamin E on the Renal Cortex in Rats: An Ultrastructure Study

The effect of supplementing dietary selenium (Se) and vitamin E was investigated in 330 24-week-old laying hens. The hens were fed a basal diet containing Se and α-tocopherol at 0.11 and 26 mg/kg, respectively, or a diet supplemented with Se at 0.3 mg/kg and vitamin E between 0 and 625 mg/kg. Se was supplied as Se-methionine or sodium selenite. The eggs were collected for analysis during the third, seventh and eleventh weeks of the experiment. Supplementation of either form of Se significantly increased the Se concentration in egg yolks and whites, with a more pronounced effect caused by Se-methionine. The egg yolk α-tocopherol concentration paralleled the dietary α-tocopherol concentration. At a high dietary α-tocopherol concentration (632 mg/kg), the retinol content in egg yolks from hens fed Se-methionine increased significantly. Supplementation of Se-methionine significantly increased the α-tocopherol content in the eggs in the third and seventh weeks of the experiment. A moderate decrease in yolk cholesterol was observed in hens fed Se-methionine and α-tocopherol at 119 mg/kg. The concentration of products from lipid peroxidation (thiobarbituric acid-reactive substances, TBARS) in egg yolks increased marginally during the refrigerated storage of the eggs for 2 weeks. The effect of dietary vitamin E on TBARS formation was generally small, although a more significant effect was observed at the highest dose tested.

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Effect of dietary selenium on lipid oxidation, selenium and vitamin E content in the meat of broiler chickens

Czech Journal of Animal Science ◽

10.17221/358-cjas ◽

2008 ◽

Vol 53 (No. 7) ◽

pp. 306-311 ◽

Cited By ~ 15

Author(s):

M. Skřivan ◽

G. Dlouhá ◽

O. Mašata ◽

S. Ševčíková

Keyword(s):

Vitamin E ◽

Broiler Chickens ◽

Sodium Selenite ◽

Basal Diet ◽

Tocopherol Content ◽

Dietary Sodium ◽

Breast Meat ◽

Tocopherol Concentration ◽

Broiler Meat ◽

Dietary Treatments

An experiment was conducted to compare the effect of dietary sodium selenite and selenomethionine on selenium and α-tocopherol concentration in breast meat, oxidative stability of meat in broilers, and on growth performance, but only as an unimportant criterion in this case. Sexed broiler cockerels Ross 308 were allocated to 3 dietary treatments, each comprising 100 chickens. The basal diet was supplemented with 0 (control) or 0.3 mg/kg Se from sodium selenite (SS) or selenomethionine (SM). Dietary supplementation with SM increased (P < 0.05) body weight, but only by about 3%. Breast muscle Se concentration was increased (P < 0.05) by both Se sources, but more by SM (1.32 mg/kg dry matter; 0.47 mg/kg DM in control). The concentration of Se in excreta was 3 times higher with SS supplement than with SM supplement. Dietary Se supplementation increased (P < 0.05) the α-tocopherol content of breast meat from 25.9 mg/kg DM in the control to 33.2 mg/kg DM when SM supplementation was used. Furthermore, lipid peroxidation decreased compared to the control. The inclusion of SM in the diet reduced (P < 0.05) malondialdehyde (MDA) values in breast samples after 0, 3, and 5 days of cooler storage, whereas SS decreased (P < 0.05) the MDA of breast meat after 0 and 3 days of storage. The results of this experiment indicate that selenomethionine in the diet of broilers is capable of simultaneously increasing the content of selenium and vitamin E in broiler meat plus its stability in storage.

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Cell-biology of ageing. II. The effect of vitamin E, vitamin C and sodium selenite on the ageing syndromes of early senescent mutants of

Cell Biology International Reports ◽

10.1016/0309-1651(83)90126-1 ◽

1983 ◽

Vol 7 (6) ◽

pp. 404

Author(s):

M ISLAM ◽

A NESSA

Keyword(s):

Vitamin E ◽

Vitamin C ◽

Cell Biology ◽

Sodium Selenite

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Effect of Dietary Selenite on Hepatic Organic Solvent-Soluble Lipofuscin Pigments

Journal of the American College of Toxicology ◽

10.3109/10915818609140738 ◽

1986 ◽

Vol 5 (1) ◽

pp. 79-85 ◽

Cited By ~ 8

Author(s):

A.S. Csallany ◽

B.Z. Menken

Keyword(s):

Lipid Peroxidation ◽

Vitamin E ◽

Glutathione Peroxidase ◽

Organic Solvent ◽

Normal Level ◽

Sodium Selenite ◽

Basal Diet ◽

Glutathione Peroxidase Activity ◽

End Products ◽

Oxidative Effect

Supplementation of selenium as sodium selenite results in an increase in hepatic organic solvent-soluble lipofuscin pigments, the metabolic end products of lipid peroxidation. Weanling mice fed a basal diet containing 0.05 ppm selenium had a significant increase in hepatic organic solvent-soluble lipofuscin pigments and glutathione peroxidase activity following supplementation of an additional 0.1 ppm selenium as sodium selenite from 5 to 9 months of age. Normal levels of vitamin E (30 mg/kg) were insufficient to protect against the oxidative effect of this increased dose of selenite. However, 10 times the normal level of vitamin E markedly suppressed this oxidative effect.

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Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice

Pharmaceutical Sciences ◽

10.34172/ps.2020.89 ◽

2020 ◽

Vol 27 (3) ◽

pp. 339-344

Author(s):

Bohloul Habibi-Asl ◽

Alireza Parvizpur ◽

Kiarash Fekri ◽

Hadis Jahanpanah ◽

Hadis Rezaei ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Synergistic Effect ◽

Sodium Selenite ◽

The Body ◽

The Other ◽

Essential Trace Element ◽

Male Mice ◽

Almond Oil ◽

Biochemical Pathways

Background: Antioxidant drugs may be useful in preventing morphine-induced dependency bysuppressing oxidative stress. Vitamin E which has many essential roles in the body is a powerfulantioxidant. On the other hand, selenium is an essential trace element that plays a strong rolein various biochemical pathways. The aim of this study was to investigate the effects of sodiumselenite and vitamin E on morphine-induced dependency in mice. Methods: Ninety male mice, weighing 20 to 30 g, were randomly divided into 10 groups and weretreated as follows: a) saline and b) morphine groups were pretreated (for 2 days) with normalsaline (10 ml.kg-1.day-1, ip) then daily doses of normal saline (10 ml.kg-1.day-1, ip) and morphine(50 mg.kg-1.day-1) were added to the injections for the following 4 days, respectively. c, d, e)sodium selenite, f, g, h) vitamin E, i) vitamin E solvent (almond oil) and j) co-administrationgroups were pretreated (for 2 days) with sodium selenite (0.25, 0.5, 1 mg.kg-1.day-1, ip), vitaminE (20, 40, 60 IU.kg-1.day-1, ip), vitamin E solvent (10 ml.kg-1.day-1, ip) and combination of thedrugs respectively, then morphine doses (50 mg.kg-1.day-1, ip) were added to the injections forthe following 4 days. Withdrawal symptoms were evaluated after injecting naloxone (4 mg/kg/day). Biochemical evaluations were also performed. Results: The results showed that co-administration of sodium selenite and vitamin E (at lowdoses) significantly reduced morphine dependency (p < 0.05). Conclusion: The synergistic effect of sodium selenite and vitamin E can be a suitable andefficient approach to reduce dependency.

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