Cell-biology of ageing. II. The effect of vitamin E, vitamin C and sodium selenite on the ageing syndromes of early senescent mutants of

Two hundred and forty laying hens were fed diets supplemented with vitamin C and selenium (Se). Vitamin C was added at 0 or 200 mg/kg, and Se was added as sodium selenite or selenized yeast at 0.3 mg/kg. The feed intake and egg production were measured, and egg quality parameters were determined. Supplementation of the basal diet with Se significantly increased the laying performance; however, vitamin C significantly decreased feed intake and egg production. Vitamin C increased vitamin E concentration in the yolk. Both selenite and Se-enriched yeast increased the vitamin E concentration in the yolk and the Se concentration in the yolk and albumen. The oxidative stability of yolk lipids was improved in hens fed diets supplemented with sodium selenite, but not in those fed diets supplemented with Se-yeast. After 28 days of storage, however, the beneficial effect of selenite on lipid stability ceased. The supplementation of the basal diet with vitamin C significantly worsened the oxidative stability of yolk lipids, indicating that vitamin C acted as a pro-oxidant. Thus, vitamin C increased the laying performance and influenced some traits of egg quality. The combined supplementation of vitamin C and Se did not prove to be successful.

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Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP Trial): randomised placebo-controlled trial

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70061-4 ◽

2007 ◽

Vol 2007 ◽

pp. 80-82

Author(s):

S. Thung

Keyword(s):

At Risk ◽

Vitamin E ◽

Vitamin C ◽

Pregnant Women ◽

Controlled Trial

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Faculty Opinions recommendation of Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1103244.559253 ◽

2008 ◽

Author(s):

Patrick Nana-Sinkam

Keyword(s):

Lung Cancer ◽

Vitamin E ◽

Vitamin C

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Dietary and circulating vitamin C, vitamin E, β-carotene and risk of total cardiovascular mortality: a systematic review and dose–response meta-analysis of prospective observational studies

Public Health Nutrition ◽

10.1017/s1368980018003725 ◽

2019 ◽

Vol 22 (10) ◽

pp. 1872-1887 ◽

Cited By ~ 8

Author(s):

Ahmad Jayedi ◽

Ali Rashidy-Pour ◽

Mohammad Parohan ◽

Mahdieh Sadat Zargar ◽

Sakineh Shab-Bidar

Keyword(s):

Systematic Review ◽

Vitamin E ◽

Vitamin C ◽

Dose Response ◽

Observational Studies ◽

Meta Analysis ◽

Dietary Intakes ◽

Relative Risks ◽

Β Carotene ◽

Cvd Mortality

AbstractObjectiveThe present review aimed to quantify the association of dietary intake and circulating concentration of major dietary antioxidants with risk of total CVD mortality.DesignSystematic review and meta-analysis.SettingSystematic search in PubMed and Scopus, up to October 2017.ParticipantsProspective observational studies reporting risk estimates of CVD mortality across three or more categories of dietary intakes and/or circulating concentrations of vitamin C, vitamin E and β-carotene were included. A random-effects meta-analysis was conducted.ResultsA total of fifteen prospective cohort studies and three prospective evaluations within interventional studies (320 548 participants and 16 974 cases) were analysed. The relative risks of CVD mortality for the highest v. the lowest category of antioxidant intakes were as follows: vitamin C, 0·79 (95 % CI 0·68, 0·89; I2=46 %, n 10); vitamin E, 0·91 (95 % CI 0·79, 1·03; I2=51 %, n 8); β-carotene, 0·89 (95 % CI 0·73, 1·05; I2=34 %, n 4). The relative risks for circulating concentrations were: vitamin C, 0·60 (95 % CI 0·42, 0·78; I2=65 %, n 6); α-tocopherol, 0·82 (95 % CI 0·76, 0·88; I2=0 %, n 5); β-carotene, 0·68 (95 % CI 0·52, 0·83; I2=50 %, n 6). Dose–response meta-analyses demonstrated that the circulating biomarkers of antioxidants were more strongly associated with risk of CVD mortality than dietary intakes.ConclusionsThe present meta-analysis demonstrates that higher vitamin C intake and higher circulating concentrations of vitamin C, vitamin E and β-carotene are associated with a lower risk of CVD mortality.

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Combined Treatment with Vitamin E and Vitamin C Decreases Oxidative Stress and Improves Fetal Outcome in Experimental Diabetic Pregnancy

Pediatric Research ◽

10.1203/00006450-200106000-00007 ◽

2001 ◽

Vol 49 (6) ◽

pp. 755-762 ◽

Cited By ~ 115

Author(s):

Jonas Cederberg ◽

C Martin Simán ◽

Ulf J Eriksson

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Vitamin C ◽

Combined Treatment ◽

Fetal Outcome ◽

Diabetic Pregnancy

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Effect of Sodium Selenite and Vitamin E on the Renal Cortex in Rats: An Ultrastructure Study

Tissue and Cell ◽

10.1016/j.tice.2014.03.002 ◽

2014 ◽

Vol 46 (3) ◽

pp. 170-177 ◽

Cited By ~ 4

Author(s):

Adel M. Hussein ◽

Hamid A. Saleh ◽

Mustafa H.N.

Keyword(s):

Vitamin E ◽

Sodium Selenite ◽

Renal Cortex ◽

Ultrastructure Study

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Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis

Scientific Reports ◽

10.1038/srep09599 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 14

Author(s):

Fuqiang Chen ◽

Qingshu Li ◽

Yang Yu ◽

Wenrong Yang ◽

Fei Shi ◽

...

Keyword(s):

Vitamin D ◽

Bladder Cancer ◽

Vitamin E ◽

Vitamin C ◽

Dose Response ◽

Meta Analysis

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Feeding antioxidant vitamin and vegetable oils to broilers: vitamin E reduced negative effect of soybean oil on immune response and meat lipid oxidation

Animal Production Science ◽

10.1071/an16677 ◽

2018 ◽

Vol 58 (10) ◽

pp. 1829

Author(s):

M. Mohiti-Asli ◽

M. Ghanaatparast-Rashti

Keyword(s):

Immune Response ◽

Vitamin E ◽

Vitamin C ◽

Soybean Oil ◽

Lipid Oxidation ◽

Vegetable Oil ◽

Canola Oil ◽

Cellular Response ◽

Dietary Supplementation ◽

Antioxidant Vitamin

This study investigated the effect of feeding vitamin E, vitamin C, and two sources of vegetable oil on immune response and meat quality of broilers. A total of 320 one-day-old chicks were used in a completely randomised design with eight treatments arranged as a 2 × 2 × 2 factorial with two levels of vitamin E (0 and 200 mg/kg), two levels of vitamin C (0 and 1000 mg/kg), and two sources of vegetable oil (soybean and canola). Dietary supplementation of either vitamin E or C increased (P < 0.05) secondary humoral response, whereas oil sources had no significant effect. Broilers fed soybean oil had lower cellular response to the phytohemagglutinin skin test than those fed canola oil in diet, and supplementation of vitamin E increased cellular immune response. However, fat, cholesterol and pH of meat were not affected by source of oil or antioxidants, lipid oxidation was higher (P < 0.05) in thigh and breast meat of broilers fed soybean oil than canola oil. Dietary supplementation of vitamin E decreased (P < 0.05) lipid oxidation in thigh and breast of broilers fed diet containing soybean oil, without any effect on meat oxidation of those fed canola oil. Dietary supplementation of vitamin C increased lipid oxidation in thigh meat of broilers (P < 0.05). It can be concluded that inclusion of soybean oil to the diet, compared with canola oil, increased need for antioxidant. Vitamin E had beneficial effects on immune response and reduced meat lipid oxidation; nonetheless future studies should explore the antioxidant effect of vitamin C in stored meat.

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