Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

2005 ◽  
Vol 16 (6-7) ◽  
pp. 289-297 ◽  
Author(s):  
G.J. Peters ◽  
J.H. Hooijberg ◽  
G.J.L. Kaspers ◽  
G. Jansen
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

The Role of Folate-Supplementation in Depression: A Narrative Review

2020 ◽  
Vol 09 ◽  
Author(s):  
Falade Joshua ◽  
Onaolapo Adejoke Yetunde ◽  
Onaolapo Olakunle James
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Folic Acid Supplementation ◽  
Narrative Review ◽  
Folate Supplementation ◽  
Acid Supplementation ◽  
Vitamin Deficiencies ◽  
Normal Tissues ◽  
Antidepressant Use

Background:: There is a relationship between the etiology and management of clinical depression and vitamin deficiencies. Aim:: To review the effect of dietary folic acid supplementation on cause, severity and treatment of depres-sion. Methods:: A narrative review of empirical and theoretical literature on the effect of folic acid supplementation on the se-verity and treatment outcomes of depression. Result:: Many enzymes and neurotransmitters depend on folic acid for optimal functions. The monoamine hypothesis of depression confirms the depletion of serotonin, dopamine, and norepinephrine. The systemic level of methyl folate is de-pendent upon the enzyme methylenetetrahydrofolate reductase [MTHFR], which is encoded for by a polymorphic gene [C677T-MTHFR], as well as being dependent on dietary folic acid intake. However, folate has procarcinogenic properties because its coenzymes are involved in de novo purine and thymine nucleotide biosynthesis. Besides, folate deficiency in normal tissues may also predispose to neoplastic transformation, while folate supplementation may suppress the develop-ment of tumors in normal tissues. Epidemiological studies revealed that low folate status is associated with depression; especially in terms of severity and the outcome of antidepressant use. Conclusion: The role of folic acid in the etiology and the management of depression cannot be overemphasized. Folate supplementation has been yielding positive results in the management of depression. :

Role of folic acid supplementation and/ or its absence during pregnancy on implantation of embryos – An experimental study of Wistar rats

2018 ◽  
Vol 67 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Prasanna Lokadolalu Chandracharya ◽  
Rohini Alva ◽  
Mamatha Hosapatna ◽  
Anjaneyalu Konuri ◽  
Ashok Kumar
Keyword(s):  
Experimental Study ◽  
Folic Acid ◽  
Wistar Rats ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

scholarly journals Folic Acid Supplementation for Women of Childbearing Age versus Supplementation for the General Population: A Review of the Known Advantages and Risks

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Nikhil Shelke ◽  
Louis Keith
Keyword(s):  
Folic Acid ◽  
Human Growth ◽  
Folic Acid Supplementation ◽  
Evidence Based ◽  
Women Of Childbearing Age ◽  
Clinical Practices ◽  
Childbearing Age ◽  
Acid Supplementation ◽  
Human Growth And Development

This paper focuses on the current best-evidence-based clinical practices and controversies surrounding folic acid supplementation/fortification for the prevention of neural tube defects (NTDs) during early pregnancy. The paper also discusses the controversies surrounding the effect of folic acid on the prevention as well as the promotion of cancer. Sufficient data is available to safely conclude that folic acid reduces the risk of NTDs during pregnancy; however, a safe dosage has not yet been calculated for the rest of the population. More research is necessary to study the complete role of folic acid in human growth and development.

scholarly journals Effectiveness of Folic Acid Supplementation Recommendations among Polish Female Students from the Podkarpackie Region

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1001
Author(s):  
Maria Zadarko-Domaradzka ◽  
Ewa Kruszyńska ◽  
Emilian Zadarko
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Cross Sectional Study ◽  
Key Factors ◽  
Childbearing Age ◽  
Chi Square ◽  
Cross Sectional ◽  
Acid Supplementation ◽  
Chi Square Test

Adequate folic acid supplementation during the preconception period is an important element in the primary prevention of neural tube defects (NTDs). This study aims to study the effectiveness of folic acid supplementation recommendations among women of childbearing age, and to assess and characterise their awareness about this public health measure. The cross-sectional study included women (N = 1285) aged 22.27 ± 4.6 years old on average. Some of the results were obtained on a subgroup of women (N = 1127) aged 21.0 ± 2.1. This study was performed using a questionnaire. The analysis was performed with the use of a logistic regression model, chi-square test for independence and odds ratio (OR). According to the results, only 13.9% of women supplement folic acid, and 65.3% of them do so daily. A total of 91.1% of the respondents were not aware of its recommended dose and 43% did not know the role it plays in the human body. Among women who do not currently supplement folic acid (N = 1052), 52.4% declared doing so while planning their pregnancy. Women’s awareness about the role of folic acid in NTD prevention (OR = 4.58) and the information they got from physicians (OR = 1.68) are key factors that increased the odds of the women taking folic acid before pregnancy. There is therefore a need for more information and education campaigns to raise awareness about folic acid.

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