Nanoparticles have many characteristics that make them suitable for biological and medical applications. These special features cause some adverse effects. Despite the widespread use of titanium dioxide nanoparticles, few studies were conducted on the toxicity of these nanoparticles in biological systems. In this study, the effects of intraperitoneal injections of TiO2 nanoparticles (30,50,70 mg/kg ) were investigated on kidney function and histology. The creatinine levels did not change but the amount of urea and uric acid showed the significant changes in comparison with control group. But, by passing the time, the uric acid changes back to normal. In kidney tissue, the changes such as deposition of hyaline-like materials, the swelling, dilatation of Bowman's capsule and degenerations were seen. It seems by passing time, The temporary disorders have been removed and the renal function has returned toward normal. However, further investigations are needed to measure the oxidative stress.International Journal of Life Sciences 10 (1) : 2016; 65-69
Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: Implications for nicotine product standards.