Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

The aim of this sub-chronic toxicity study is to determine the protective effects of Resveratrol (Res) on oxidative stress, biochemical and histopathological changes induced by glyphosate-based herbicide (GBH) in the blood, brain, heart, liver and renal tissues.

Download Full-text

Prophylactic effect of vitamin E against hepatotoxicity, nephrotoxicity, haematological indices and histopathology induced by diazinon insecticide in mice

Current Zoology ◽

10.1093/czoolo/55.3.219 ◽

2009 ◽

Vol 55 (3) ◽

pp. 219-226 ◽

Cited By ~ 11

Author(s):

Nahla S. El-Shenawy ◽

Rasha A. Al-Eisa ◽

Fawzia El-Salmy ◽

Omema Salah

Keyword(s):

Body Weight ◽

Vitamin E ◽

Kidney Function ◽

Kidney Tissue ◽

The Body ◽

High Dose ◽

Protective Effects ◽

Histopathological Changes ◽

Liver And Kidney ◽

Haematological Indices

Abstract Considering that the involvement of reactive oxygen species (ROS) has been implicated in the toxicity of various pesticides, this study was designed to study the ameliorative effect of Vitamin E (100 mg/kg body weight) on mice (25 - 30 mg) treated with diazinon (32.5 or 16.25 mg/kg body weight) organophosphate insecticide for 14 days. Subchronic DZN exposure and the protective effects of vitamins E (vitE) were evaluated for their effects on haematological indices, the enzymes concerning liver damage [plasma alanine aminotransferase (ALT), aspartate aminotaransferase (AST), alkaline phosphatise (AIP), and some parameters of kidney function (urea and creatinine) in mice. Additionally, the histopathological changes in liver and kidney tissue were examined. The high dose of diazinon (DZNH) decreased the body weight significantly at the end of experiment. Additionally, the liver and kidney were examines for histopathological changes. The high dose of diazinon decreased body weight significantly. Moreover, there was a statistically significant decrease in haemoglobin (Hb), red blood cell (RBC) and hematocrit (Hct) in diazinon-treated mice compared to controls. This decrease was partially remedied in the diazinon-treated group that also received vitE. Damage in the liver and kidney tissues was also evident as elevated plasma ALT, AST, ALP, urea and creatinine. VitE partially counteracts the toxic effect of DZN and repairs tissue damage in the liver and kidney, especially when supplemented to 1/4 LD50 intoxicated animals. Histopathological changes in liver and kidney were observed only in 32.5 mg/kg DZN given group. These results suggest that the effects of DZN are dose dependent. No pathological findings were observed in vitE + DZN treated groups. According to the present study, we conclude that vitE can reduce the detrimental impacts of diazinon on haematological indicies, as well as liver and kidney function.

Download Full-text

HISTOLOGICAL STUDY ON THE PROTECTIVE EFFECTS OF TAMARIND SEED EXTRACT ON COBRA VENOM IN MICE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i10.20040 ◽

2017 ◽

Vol 10 (10) ◽

pp. 301

Author(s):

Imad M Al-ani ◽

Soraya Ismail ◽

Khin M Maung ◽

Pakeer Oothuman ◽

Sinan Mohammed Abdullah Al-mahmood

Keyword(s):

Histological Study ◽

Seed Extract ◽

Cobra Venom ◽

Control Group ◽

Protective Effects ◽

Histopathological Changes ◽

Tamarind Seed ◽

Snake Bites ◽

Medical Plant ◽

Liver And Kidney

Objective: Tamarind (Tamarindus indica) has been used as a medical plant for treating many human and animal diseases and widely used as a traditional herbal medicine for the treatment of snake bites. The objective of the study is to investigate whether tamarind seed extract (TSE) has neutralization activity on an adverse histological reaction against venoms of the King Cobra.Methods: A total of 20 healthy mature male mice were randomly divided into 4 groups with 5 mice in each. The control group was injected with 1 ml of normal saline. The second group was injected subcutaneously with a single dose of 24.96 μg/20 g King Cobra venom (KCV) solution. The third group was injected with the same dose of KCV solution and 10 mg/20 g of TSE. The fourth group was injected with the same dose of KCV solution and 15 mg/20 g TSE solution. The animals were sacrificed after 24 hrs of injection of the solution. Fragments of muscle, kidney, and liver were fixed in 10% neutral buffered formalin and processed for light microscopical studies.Results: The result showed that TSE reduced the histopathological changes induced by the KCV in the muscles, livers, and kidneys, and the improvement was proportional to the applied dose of the TSE indicating that TSE prevents adverse histological changes in the muscle, liver, and kidney.Conclusion: The present study demonstrated that TSE reduced the histopathological changes in the muscle, liver, and kidney induced by KCV in mice.

Download Full-text

Protective Effects of Zinc on Cadmium Toxicity in Rodents

Biological Trace Element Research ◽

10.1385/bter:75:1-3:1 ◽

2000 ◽

Vol 75 (1-3) ◽

pp. 1-9 ◽

Cited By ~ 29

Author(s):

C. Claverie ◽

R. Corbella ◽

D. Martín ◽

C. Díaz

Keyword(s):

Cadmium Toxicity ◽

Protective Effects

Download Full-text

Screening of lactic acid bacteria with potential protective effects against cadmium toxicity

Food Control ◽

10.1016/j.foodcont.2015.01.037 ◽

2015 ◽

Vol 54 ◽

pp. 23-30 ◽

Cited By ~ 61

Author(s):

Qixiao Zhai ◽

Ruijie Yin ◽

Leilei Yu ◽

Gang Wang ◽

Fengwei Tian ◽

...

Keyword(s):

Lactic Acid ◽

Lactic Acid Bacteria ◽

Cadmium Toxicity ◽

Protective Effects

Download Full-text

Cadmium Toxicity in Spermatogenesis and Protective Effects of l-Carnitine in Adult Male Rats

Biological Trace Element Research ◽

10.1007/s12011-009-8577-5 ◽

2009 ◽

Vol 137 (2) ◽

pp. 216-225 ◽

Cited By ~ 23

Author(s):

Abazar Yari ◽

Mohammad Hossein Asadi ◽

Hossein Bahadoran ◽

Hossein Dashtnavard ◽

Hossein Imani ◽

...

Keyword(s):

Adult Male ◽

Cadmium Toxicity ◽

Male Rats ◽

Protective Effects

Download Full-text

Protective effects of synbiotic diets of Bacillus coagulans, Lactobacillus plantarum and inulin against acute cadmium toxicity in rats

BMC Complementary and Alternative Medicine ◽

10.1186/s12906-017-1803-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 12

Author(s):

Dornoush Jafarpour ◽

Seyed Shahram Shekarforoush ◽

Hamid Reza Ghaisari ◽

Saeed Nazifi ◽

Javad Sajedianfard ◽

...

Keyword(s):

Lactobacillus Plantarum ◽

Cadmium Toxicity ◽

Bacillus Coagulans ◽

Protective Effects

Download Full-text

Protective Effect of Rosmarinic Acid is Through Regulation of Inflammatory Cytokine in Cadmium-Induced Ototoxicity

The American Journal of Chinese Medicine ◽

10.1142/s0192415x13500298 ◽

2013 ◽

Vol 41 (02) ◽

pp. 391-404 ◽

Cited By ~ 12

Author(s):

Su-Jin Kim ◽

Jae-Young Um ◽

Sung-Hoon Kim ◽

Seung-Heon Hong

Keyword(s):

Auditory System ◽

Rosmarinic Acid ◽

Ex Vivo ◽

Biological Activities ◽

Wide Spectrum ◽

Cadmium Toxicity ◽

Reactive Oxygen Species Generation ◽

Protective Effects ◽

Pharmacological Mechanism

Cadmium ( Cd2+ ) is an environmental contaminant that causes a variety of adverse effects. Auditory cells are sensitive to cadmium, and the cochlea is more vulnerable to cadmium toxicity than the other parts of the auditory system. Rosmarinic acid (RA) exhibits a wide spectrum of biological activities, mainly antioxidant and anti-inflammatory activities. However, the regulatory effects of RA in the auditory system have not been elucidated. In this study, we investigated the protective effects of RA on Cd2+ -induced ototoxicity in vitro and ex vivo. The findings showed that RA inhibited Cd2+ -mediated cell toxicity, reactive oxygen species generation, interleukin (IL)-6 and IL-1β production, the translocation of the apoptosis inducing factor into the nucleus and activation of caspases-3 in an auditory cell line, HEI-OC1. In addition, RA prevented the destruction of hair cell arrays in the rat organ of Cortiprimary explants in the presence of Cd2+ . These results are expected to improve our understanding of the pharmacological mechanism of RA, and help develop potential therapeutic strategies against ototoxicity.

Download Full-text