scholarly journals Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

2021 ◽  
Author(s):  
Hayato Tajiri ◽  
Wataru Tanaka ◽  
Masakatsu Takashima ◽  
Hiroki Matsuyama ◽  
Takuya Sugita ◽  
...  
Keyword(s):  
Mangifera Indica ◽  
Safety Evaluation ◽  
Water Extract ◽  
Hot Water ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Hot Water Extract

scholarly journals Safety Evaluation of Hot-Water Extract of Hatake-shimeji (Lyophyllum decastes Sing.)

2007 ◽  
Vol 54 (3) ◽  
pp. 133-137 ◽  
Author(s):  
Yuuichi Ukawa ◽  
Yasushi Kojima ◽  
Keijiro Soma ◽  
Takashi Mishima ◽  
Makoto Hisamatsu
Keyword(s):  
Safety Evaluation ◽  
Water Extract ◽  
Hot Water ◽  
Hot Water Extract ◽  
Lyophyllum Decastes

scholarly journals In Vivo Toxicity and the Antioxidant Activity of the Hot Water Extract of Glechoma Hederacea

2020 ◽  
Author(s):  
Yun-Chin Chung ◽  
Jiunn-Wang Liao ◽  
Kuo-Yuan Li ◽  
Jyun-Kai Jhan ◽  
Su-Tze Chou
Keyword(s):  
Adverse Effect ◽  
Water Extract ◽  
Hot Water ◽  
Oral Toxicity ◽  
Subacute Toxicity ◽  
Hot Water Extract ◽  
Adverse Effect Level ◽  
Effect Level ◽  
Glechoma Hederacea

Abstract Background Glechoma hederacea belongs to the Labiatae family and has many biological effects. Our previously in vitro studies, hot water extract of G. hederacea (HWG) possessed antioxidant and anti-inflammatory activities. Also, the Ames test indicated that HWG had no mutagenicity. However, the in vivo toxicity and antioxidant capacity have not been clearly demonstrated. Thus, this study was aimed to evaluate the antioxidant properties and the safety level of HWG by using animal models. Methods The genotoxicity were performed by micronucleus assays in mice. Acute oral toxicity and 28-day repeated feeding toxicity tests were performed via the oral gavage method for Sprague-Dawley (SD) rats. Furthermore, the effect of HWG on the oxidation–antioxidation equilibrium of male rats was also evaluated. Results HWG did not induce an increase in micronucleus ratios in vivo, no acute lethal effect at a maximum tested dose of 5.0 g HWG /kg bw was observed in rats. The 28-day oral toxicity study revealed the no observed adverse effect level (NOAEL) of HWG in rats was 1.0 g/kg bw. The HWG-treatment significantly elevated the vitamin C level and the SOD activity in heart, and increased the vitamin E concentrations in brain. The HWG-treatment maintained the balance of the glutathione level and the activities of catalase and glutathione peroxidase. Besides, the level of lipid peroxidation and plasma of total antioxidant status (TAS) showed that HWG-treated rats were not significantly changed compared with the control group. Conclusions HWG had no genotoxicity, and did not induce acute or subacute toxicity in SD rat. The level of no observed adverse effect level (NOAEL) of HWG rats was 1.0 g/kg bw for subacute toxicity study. HWG possessed antioxidant potential and reduced oxidative stress by improving the antioxidant system in animal.

scholarly journals Acute Oral Toxicity Test of Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats

2009 ◽  
Vol 6 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Hirotaka HAYASHI ◽  
Yasuyuki OHTA ◽  
Takanari ARAI ◽  
Yasuko SHIMANO ◽  
Fumihide TAKANO ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Water Extract ◽  
Hot Water ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Hot Water Extract

Effects of a Hot-Water Extract of Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae) on the Recovery of Rat Liver Function

2000 ◽  
Vol 2 (1) ◽  
pp. 7
Author(s):  
Byong Kak Kim ◽  
Sang Eun Park ◽  
So Young Kim ◽  
Jin Won Hyun ◽  
Ha Won Kim ◽  
...  
Keyword(s):  
Liver Function ◽  
Rat Liver ◽  
Trametes Versicolor ◽  
Water Extract ◽  
Hot Water ◽  
Hot Water Extract

Physiological Activities of the Hot Water Extract from Eriobotrya japonica Lindl.

2009 ◽  
Vol 38 (8) ◽  
pp. 977-982 ◽  
Author(s):  
Yoo-Seok Jeong ◽  
Hee-Kyoung Jung ◽  
Kwang-Sup Youn ◽  
Myoung-Ok Kim ◽  
Joo-Heon Hong
Keyword(s):  
Water Extract ◽  
Hot Water ◽  
Eriobotrya Japonica ◽  
Hot Water Extract

Suppressive effect of hot water extract of wasabi (Wasabia japonica Matsum.) leaves on the differentiation of 3T3-L1 preadipocytes

2010 ◽  
Vol 118 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Tetsuro Ogawa ◽  
Hiromasa Tabata ◽  
Takuya Katsube ◽  
Yukari Ohta ◽  
Yukikazu Yamasaki ◽  
...  
Keyword(s):  
Water Extract ◽  
Suppressive Effect ◽  
Hot Water ◽  
Wasabia Japonica ◽  
Hot Water Extract

scholarly journals A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production

2017 ◽  
Vol 6 ◽  
Author(s):  
Ryusei Uchio ◽  
Yohei Higashi ◽  
Yusuke Kohama ◽  
Kengo Kawasaki ◽  
Takashi Hirao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Oral Administration ◽  
Alanine Aminotransferase ◽  
Curcuma Longa ◽  
Water Extract ◽  
Hot Water ◽  
Hepatic Tissue ◽  
Hot Water Extract ◽  
Acute Ethanol

AbstractTurmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). Plasma levels of aspartate aminotransferase and alanine aminotransferase were markedly increased in ethanol-treated mice, while the increase of these enzymes was significantly suppressed by prior administration of WEC. The increase of alanine aminotransferase was also significantly suppressed by pretreatment with bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA. These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone.

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