scholarly journals Effect of Tannic Acid-templated Mesoporous Silica Nanoparticles on Iron-Induced Oxidative Stress and Liver Toxicity in Rats

2021 ◽  
Author(s):  
Hossein Javdani ◽  
Leila Etemad ◽  
Mohammad Moshiri ◽  
Asghar Zarban ◽  
Mohammad Yahya Hanafi-Bojd
Keyword(s):  
Oxidative Stress ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Liver Toxicity ◽  
Mesoporous Silica Nanoparticles

scholarly journals pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization

2021 ◽  
Author(s):  
Yi Liu ◽  
Yeying Wang ◽  
Bing Xiao ◽  
Guoke Tang ◽  
Jiangming Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ammonia Borane ◽  
Neural Regeneration ◽  
Dependent Manner ◽  
Cord Injury

Abstract Imbalance of oxidative and inflammatory regulation is the main contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury (SCI). As an emerging biosafe strategy for protecting against oxidative and inflammatory damage, hydrogen (H2) therapy is a promising approach for improving the microenvironment to allow neural regeneration. However, achieving release of H2 at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H2. Thus, we assembled SiO2@mSiO2 mesoporous silica nanoparticles and loaded them with ammonia borane (AB), which has abundant capacity and allows controllable release of H2 in an acid-dependent manner. The release of H2 from AB/SiO2@mSiO2 was satisfactory at pH 6.6, which is approximately equal to the microenvironmental acidity after SCI. After AB/SiO2@mSiO2 were intrathecally administered to rat models of SCI, continuous release of H2 from these nanoparticles synergistically enhanced neurofunctional recovery, reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction. Furthermore, in the subacute phase of SCI, microglia were markedly polarized toward the M2 phenotype by H2 via inhibition of TLR9 expression in astrocytes. In conclusion, H2 delivery through AB/SiO2@mSiO2 has the potential to efficiently treat SCI through comprehensive modulation of the oxidative and inflammatory imbalance in the microenvironment.

Tannic acid-templated mesoporous silica nanoparticles as an effective treatment in acute ferrous sulfate poisoning

2020 ◽  
Vol 307 ◽  
pp. 110486
Author(s):  
Hossein Javdani ◽  
Rasoul Khosravi ◽  
Leila Etemad ◽  
Mohammad Moshiri ◽  
Asghar Zarban ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Effective Treatment ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Ferrous Sulfate ◽  
Mesoporous Silica Nanoparticles

Improved Performance of Lipase Immobilized on Tannic Acid-Templated Mesoporous Silica Nanoparticles

2016 ◽  
Vol 179 (7) ◽  
pp. 1155-1169 ◽  
Author(s):  
Yanjun Jiang ◽  
Wenya Sun ◽  
Liya Zhou ◽  
Li Ma ◽  
Ying He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Improved Performance

scholarly journals Fabrication and characterization of novel shape-stabilized stearic acid composite phase change materials with tannic-acid-templated mesoporous silica nanoparticles for thermal energy storage

RSC Advances ◽  
2017 ◽  
Vol 7 (26) ◽  
pp. 15625-15631 ◽  
Author(s):  
Yan Chen ◽  
Xiongjie Zhang ◽  
Beifu Wang ◽  
Mengjiao Lv ◽  
Yingying Zhu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Stearic Acid ◽  
Phase Change ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Phase Change Materials ◽  
Mesoporous Silica Nanoparticles ◽  
Composite Phase Change Materials ◽  
Change Material

A novel shape-stabilized phase change material, prepared by immobilizing stearic acid onto tannic-acid-templated mesoporous silica nanoparticles.

Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2800-2809 ◽  
Author(s):  
Ming Zhou ◽  
Linlin Xie ◽  
Chen-Jie Fang ◽  
Hua Yang ◽  
Yan-Jie Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Brain Barrier ◽  
Neuronal Damage ◽  
Mesoporous Silica Nanoparticles ◽  
Barrier Permeability ◽  
Brain Barrier Permeability

MSNs are shown to have the potential to overcome the BBB and cause neuronal damage. However, the neurotoxicity potential could be mediated with surface modification.

Mesoporous silica nanoparticles for β-glucosidase immobilization by templating with a green material: Tannic acid

2020 ◽  
Vol 302 ◽  
pp. 110203 ◽  
Author(s):  
Virginia Venezia ◽  
Filomena Sannino ◽  
Aniello Costantini ◽  
Brigida Silvestri ◽  
Stefano Cimino ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Green Material

scholarly journals Enhanced Protection of Biological Membranes during Lipid Peroxidation: Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

2019 ◽  
Vol 20 (11) ◽  
pp. 2709 ◽  
Author(s):  
Lucija Mandić ◽  
Anja Sadžak ◽  
Vida Strasser ◽  
Goran Baranović ◽  
Darija Domazet Jurašin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Light Scattering ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Oxidative Activity ◽  
Model Cell

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress, i.e., lipid peroxidation induced by the addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying a combination of experimental techniques (atomic force microscopy—AFM, force spectroscopy, electrophoretic light scattering—ES and dynamic light scattering—DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

Reversibly-regulated drug release using poly(tannic acid) fabricated nanocarriers for reduced secondary side effects in tumor therapy

2020 ◽  
Vol 5 (6) ◽  
pp. 986-998
Author(s):  
Chao Chen ◽  
Tonghao Ma ◽  
Wen Tang ◽  
Xiaoli Wang ◽  
Yibing Wang ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Ph Responsive ◽  
Normal Tissues ◽  
Secondary Side

This article introduced a reversibly pH-responsive and targeting nanocarrier based on mesoporous silica nanoparticles which could be utilized to reduce the “secondary” side effects on normal tissues.

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