scholarly journals Enhanced Protection of Biological Membranes during Lipid Peroxidation: Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

2019 ◽  
Vol 20 (11) ◽  
pp. 2709 ◽  
Author(s):  
Lucija Mandić ◽  
Anja Sadžak ◽  
Vida Strasser ◽  
Goran Baranović ◽  
Darija Domazet Jurašin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Light Scattering ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Oxidative Activity ◽  
Model Cell

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress, i.e., lipid peroxidation induced by the addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying a combination of experimental techniques (atomic force microscopy—AFM, force spectroscopy, electrophoretic light scattering—ES and dynamic light scattering—DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

scholarly journals Enhanced Protection of Biological Membranes during Lipid Peroxidation. Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

2019 ◽  
Author(s):  
Anja Sadžak ◽  
Lucija Mandić ◽  
Vida Strasser ◽  
Goran Baranović ◽  
Darija Domazet Jurašin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Bioactive Molecules ◽  
Oxidative Activity ◽  
Model Cell

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress i.e. lipid peroxidation induced by addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying combination of experimental techniques (AFM, force spectroscopy, ELS, DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

scholarly journals pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization

2021 ◽  
Author(s):  
Yi Liu ◽  
Yeying Wang ◽  
Bing Xiao ◽  
Guoke Tang ◽  
Jiangming Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ammonia Borane ◽  
Neural Regeneration ◽  
Dependent Manner ◽  
Cord Injury

Abstract Imbalance of oxidative and inflammatory regulation is the main contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury (SCI). As an emerging biosafe strategy for protecting against oxidative and inflammatory damage, hydrogen (H2) therapy is a promising approach for improving the microenvironment to allow neural regeneration. However, achieving release of H2 at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H2. Thus, we assembled SiO2@mSiO2 mesoporous silica nanoparticles and loaded them with ammonia borane (AB), which has abundant capacity and allows controllable release of H2 in an acid-dependent manner. The release of H2 from AB/SiO2@mSiO2 was satisfactory at pH 6.6, which is approximately equal to the microenvironmental acidity after SCI. After AB/SiO2@mSiO2 were intrathecally administered to rat models of SCI, continuous release of H2 from these nanoparticles synergistically enhanced neurofunctional recovery, reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction. Furthermore, in the subacute phase of SCI, microglia were markedly polarized toward the M2 phenotype by H2 via inhibition of TLR9 expression in astrocytes. In conclusion, H2 delivery through AB/SiO2@mSiO2 has the potential to efficiently treat SCI through comprehensive modulation of the oxidative and inflammatory imbalance in the microenvironment.

Hierarchical mesoporous silica nanoparticles as superb light scattering materials

2016 ◽  
Vol 52 (10) ◽  
pp. 2165-2168 ◽  
Author(s):  
Jaehoon Ryu ◽  
Juyoung Yun ◽  
Jungsup Lee ◽  
Kisu Lee ◽  
Jyongsik Jang
Keyword(s):  
Light Scattering ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Multiple Scattering ◽  
Mesoporous Silica Nanoparticles ◽  
Large Surface Area ◽  
Scattering Effect ◽  
Novel Approach ◽  
Light Scattering Effect

A novel approach to enhance the light scattering effect was explored by applying hierarchical mesoporous silica nanoparticles with a radial wrinkle structure (WSNs) in DSSCs as scattering layers. The WSNs were evaluated as outstanding light scattering materials providing large surface area as well as multiple scattering.

scholarly journals Mesoporous Silica Nanoparticles in Chemical Detection: From Small Species to Large Bio-Molecules

Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 261
Author(s):  
Margarita Parra ◽  
Salvador Gil ◽  
Pablo Gaviña ◽  
Ana M. Costero
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Hybrid Materials ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Chemical Detection ◽  
Small Species

A recompilation of applications of mesoporous silica nanoparticles in sensing from the last five years is presented. Its high potential, especially as hybrid materials combined with organic or bio-molecules, is shown. Adding to the multiplying effect of loading high amounts of the transducer into the pores, the selectivity attained by the interaction of the analyte with the layer decorating the material is described. Examples of the different methodologies are presented.

Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2800-2809 ◽  
Author(s):  
Ming Zhou ◽  
Linlin Xie ◽  
Chen-Jie Fang ◽  
Hua Yang ◽  
Yan-Jie Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Brain Barrier ◽  
Neuronal Damage ◽  
Mesoporous Silica Nanoparticles ◽  
Barrier Permeability ◽  
Brain Barrier Permeability

MSNs are shown to have the potential to overcome the BBB and cause neuronal damage. However, the neurotoxicity potential could be mediated with surface modification.

scholarly journals Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 30 ◽  
Author(s):  
Diana Díaz-García ◽  
Perla Ardiles ◽  
Sanjiv Prashar ◽  
Antonio Rodríguez-Diéguez ◽  
Paulina Páez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Catalytic Oxidation ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Stress Generation ◽  
Bacterial Cells ◽  
Oxidation Activity

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity.

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1366-1375 ◽  
Author(s):  
Yannan Zhao ◽  
Xiaoxing Sun ◽  
Guannan Zhang ◽  
Brian G. Trewyn ◽  
Igor I. Slowing ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Blood Cell ◽  
Silica Nanoparticles ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
Surface Effects ◽  
Red Blood Cell Membranes
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