Transdermal drug delivery: A new frontier in the administration of therapeutic drugs to veterinary species

2006 ◽  
Vol 172 (2) ◽  
pp. 200-201 ◽  
Author(s):  
N. Villarino ◽  
M.F. Landoni
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Therapeutic Drugs ◽  
New Frontier

scholarly journals Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

2016 ◽  
Vol 19 (2) ◽  
pp. 252 ◽  
Author(s):  
Hashem Alsaab ◽  
Sindhu Prabha Bonam ◽  
Dherya Bahl ◽  
Pallabita Chowdhury ◽  
Kenneth Alexander ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Clinical Studies ◽  
Transdermal Drug Delivery ◽  
Present Review ◽  
Therapeutic Drugs ◽  
Delivery Platform ◽  
Transdermal Route ◽  
Transdermal Permeability

Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 402 ◽  
Author(s):  
Seunghee Lee ◽  
Shayan Fakhraei Lahiji ◽  
Jeesu Jang ◽  
Mingyu Jang ◽  
Hyungil Jung
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Irritation ◽  
Skin Penetration ◽  
Therapeutic Drugs ◽  
Dissolving Microneedles ◽  
Materials Used ◽  
Micro Pillars ◽  
Adhesive Materials

The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive materials used in patches may cause skin irritation, inflammation, and redness. Therefore, we developed a patchless, micro-pillar integrated DMN (P-DMN) that is simple to fabricate and enhances transdermal drug delivery compared with traditional DMN patches. The micro-pillars were made of polymethyl methacrylate at a height of 300 μm and a base diameter of 500 μm. To fabricate P-DMNs, we employed hyaluronic acid, which is a widely used derma filler and plays a role in tissue re-epithelialization. We demonstrate that utilizing P-DMNs significantly improves the delivery efficiency of an encapsulated drug surrogate (91.83% ± 7.75%) compared with traditional DMNs (64.86% ± 8.17%). Interestingly, P-DMNs remarkably increase the skin penetration accuracy rate of encapsulated drugs, up to 97.78% ± 2.22%, compared with 44.44% ± 7.85% in traditional DMNs. Our findings suggest that P-DMNs could serve as a highly accurate and efficient platform for transdermal delivery of various types of micro- and macro-biomolecules.

scholarly journals Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2557
Author(s):  
Kalvatala Sudhakar ◽  
Shivkanya Fuloria ◽  
Vetriselvan Subramaniyan ◽  
Kathiresan V. Sathasivam ◽  
Abul Kalam Azad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Active Pharmaceutical Ingredient ◽  
Reticuloendothelial System ◽  
Active Pharmaceutical Ingredients ◽  
Transdermal Drug Delivery System ◽  
Pharmaceutical Ingredients ◽  
Therapeutic Drugs ◽  
Vesicular Carriers ◽  
Bioactive Agents

A selected active pharmaceutical ingredient must be incorporated into a cargo carrier in a particular manner so that it achieves its goal. An amalgamation of active pharmaceutical ingredients (APIs) should be conducted in such a manner that it is simple, professional, and more beneficial. Lipids/polymers that are known to be used in nanocarriers for APIs can be transformed into a vesicular formulation, which offers elegant solutions to many problems. Phospholipids with other ingredients, such as ethanol and water, form suitable vesicular carriers for many drugs, overcoming many problems related to poor bioavailability, poor solubility, etc. Ultraflexible liposomes are novel carriers and new frontiers of drug delivery for transdermal systems. Auxiliary advances in vesicular carrier research have been made, enabling polymer-coated ethanolic liposomes to avoid detection by the body’s immune system—specifically, the cells of the reticuloendothelial system. Ultraflexible liposomes act as a cargo system and a nanotherapeutic approach for the transport of therapeutic drugs and bioactive agents. Various applications of liposome derivatives in different diseases are emphasized in this review.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Nanocarriers and their Actions to Improve Skin Permeability and Transdermal Drug Delivery

2015 ◽  
Vol 21 (20) ◽  
pp. 2848-2866 ◽  
Author(s):  
Nauman Khan ◽  
Mohd Harun ◽  
Asif Nawaz ◽  
Nurulaini Harjoh ◽  
Tin Wong
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeability
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