scholarly journals Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials

Vaccine ◽  
2015 ◽  
Vol 33 (46) ◽  
pp. 6241-6249 ◽  
Author(s):  
James Baggs ◽  
Kimberly Yousey-Hindes ◽  
Elizabeth Dodds Ashley ◽  
James Meek ◽  
Ghinwa Dumyati ◽  
...  
Keyword(s):  
At Risk ◽  
Clostridium Difficile ◽  
Hospital Discharge ◽  
Clostridium Difficile Infection ◽  
Population At Risk ◽  
Vaccine Trials

Clostridium Difficile Infection After Total Joint Arthroplasty: Who is at Risk?

2008 ◽  
Vol 23 (6) ◽  
pp. 839-842 ◽  
Author(s):  
Mark F. Kurd ◽  
Luis Pulido ◽  
Ashish Joshi ◽  
James J. Purtill ◽  
Javad Parvizi
Keyword(s):  
At Risk ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty

scholarly journals 497. Identification of Patients at Risk of Clostridium difficile Infection for Enrollment in Vaccine Clinical Trials

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S184-S184
Author(s):  
Vanessa Stevens ◽  
Ellyn Russo ◽  
Yinong Young-Xu ◽  
Molly Leecaster ◽  
Yue Zhang ◽  
...  
Keyword(s):  
At Risk ◽  
Clinical Trials ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Patients At Risk

scholarly journals The risk of developing a Clostridium difficile infection from the administration of different classes of antibiotics and their combinations to children in an oncological hospital

2020 ◽  
Vol 7 (1) ◽  
pp. 54-58
Author(s):  
Mariya G. Shvydkaya ◽  
◽  
Aleksandr M. Zatevalov ◽  
Dzhamilya T. Dzhandarova ◽  
Sergey D. Mitrokhin ◽  
...  
Keyword(s):  
At Risk ◽  
Clostridium Difficile ◽  
Retrospective Analysis ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients ◽  
Patient Records ◽  
Chemotherapeutic Drugs ◽  
Antimicrobial Drugs ◽  
Different Types

Patients in pediatric oncological hospitals are at risk of developing a Clostridium difficile infection. The purpose of this study was to determine the risk of developing a Clostridium difficile infection in patients who are treated with antibiotics of different classes and combinations by way of a retrospective analysis of 122 patient records. It was shown that the administration of antibacterial chemotherapeutic drugs that belong to the classes of nitrofurans (enterofuryl), sulfonamides (biseptol), cephalosporins, and macrolides/azalides significantly increased the risk of developing a Clostridium difficile infection in pediatric patients. On the contrary, treatment with antibiotics of different classes, such as linezolid, colistin, and metronidazole, significantly reduced the risk of developing a Clostridium difficile infection. The use of penicillins, aminoglycosides, fluoroquinolones, glycopeptides, and carbapenems was not associated with the risk of developing a Clostridium difficile infection in pediatric patients. The administration of one or two antimicrobial drugs of different classes increased the risk of developing a Clostridium difficile infection while a combination of three different types of antimicrobial drugs lowered the rate of this infection in pediatric patients.

Clostridium difficile Infection in Hospitalized Cirrhotic Patients with Hepatic Encephalopathy

2015 ◽  
Vol 24 (4) ◽  
pp. 423-428 ◽  
Author(s):  
Oana Cristina Stoica ◽  
Carol Stanciu ◽  
Camelia Cojocariu ◽  
Egidia Miftode ◽  
Lucian Boiculese ◽  
...  
Keyword(s):  
At Risk ◽  
Hepatic Encephalopathy ◽  
Clostridium Difficile ◽  
Enzyme Immunoassay ◽  
Clostridium Difficile Infection ◽  
Hepatorenal Syndrome ◽  
Control Group ◽  
Tertiary Referral Center ◽  
Cirrhotic Patients ◽  
Stool Samples

Background & Aims: Patients with liver cirrhosis are at-risk population for Clostridium difficile infection (CDI). There is a paucity of data on the incidence of CDI in cirrhotics with hepatic encephalopathy (HE). The aim of the study was to evaluate the incidence and risk factors for CDI in cirrhotics hospitalized with HE. Methods: A retrospective analysis of all cirrhotics with HE admitted at a tertiary referral center from January 2012 to December 2014 was made. Patients’ medical charts were reviewed, and demographics, laboratory parameters, antibiotics use, etiology of cirrhosis, and therapy of HE, as well as the results of stool samples for toxins A and B (enzyme immunoassay) were carefully searched. The presence of toxin A or B (or both) in stool samples was defined as CDI. Data on cirrhotics with HE and CDI (study group) were compared with those from patients without CDI (control group). Results: A total of 231 cirrhotic patients were hospitalized with HE mostly stage 2 and 3, and 17 (7.3%) of them were diagnosed with CDI. The overall CDI incidence rate was 57.2 cases per 10,000 patient-days. As compared with control patients, those with HE and CDI were more likely to have older age, increased serum creatinine level, hepatorenal syndrome (HRS), and more prior hospitalizations. On multivariate analysis, antibiotic therapy, age over 65 years, and HRS remained significantly related with the development of CDI. Conclusion: Hospitalized cirrhotics with HE are at risk for developing CDI, and clinicians treating such patients should be aware of this infection as rapid detection and prompt treatment may improve outcomes.Abbreviations: CDI: Clostridium difficile infection; CI: confidence interval; EIA: enzyme immunoassay; HE: hepatic encephalopathy; HRS: hepatorenal syndrome; MELD: Model for End-Stage Liver Disease; OR: odds ratio; PPIs: proton pump inhibitors; SBP: spontaneous bacterial peritonitis.

The Epidemiology of Community Clostridium difficile Infection: A Five-Year Population-Based Study on the Bailiwick of Jersey, Channel Islands

2018 ◽  
Vol 39 (5) ◽  
pp. 603-607
Author(s):  
Shankar Kumar ◽  
Irina Chis Ster ◽  
Richard Pollok ◽  
Ivan Muscat ◽  
Timothy D. Planche
Keyword(s):  
At Risk ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Population Based ◽  
Infect Control Hosp ◽  
Stable Population ◽  
Channel Islands ◽  
Population Based Study ◽  
Risk Population ◽  
Healthcare Associated

We studied healthcare-associated and community-associated Clostridium difficile infection (CDI) in Jersey, Channel Islands (2008–2012). The Island’s stable population has reliable denominator data, a clearly defined at-risk population, and healthcare contact that is easily followed. The vast majority of CDI cases had had recent healthcare contact, and true community-associated disease is extremely rare.Infect Control Hosp Epidemiol 2018;39:603–607

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