Angiogenesis and cardioprotection after TNFα-inducer-Tolpa Peat Preparation treatment in rat's hearts after experimental myocardial infarction in vivo

2005 ◽  
Vol 43 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Tadeusz F. Krzemiński ◽  
Jerzy K. Nożyński ◽  
Joanna Grzyb ◽  
Maurycy Porc ◽  
Sławomir Żegleń ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Experimental Myocardial Infarction

Scintigraphic Detection of Experimental Myocardial Infarction with 99mTc-2,3-Dimercaptosuccinic Acid

1984 ◽  
Vol 23 (06) ◽  
pp. 317-319
Author(s):  
J. Novák ◽  
Y. Mazurová ◽  
J. Kubíček ◽  
J. Yižd’a ◽  
P. Kafka ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Intravenous Administration ◽  
Experimental Myocardial Infarction ◽  
Myocardial Infarctions ◽  
Clinical Use ◽  
Scintigraphic Imaging ◽  
Tissue Samples ◽  
Scintigraphic Finding

SummaryAcute myocardial infarctions were produced by ligature of the left frontal descending coronary artery in 9 dogs. The possibility of scintigraphic imaging with 99mTc-DMSA 4 hrs after intravenous administration was studied. The infarctions were 4, 24 and 48 hrs old. The in vivo scan was positive in only one dog with a 4-hr old infarction. The in vivo scans were confirmed by the analysis of the radioactivity in tissue samples. The accumulation of the radiopharmaceutical increased slightly in 48-hr old lesions; however, this increase was not sufficient for a positive scintigraphic finding. Thus, we do not recommend 99mTc-DMSA for clinical use in acute lesions.

scholarly journals e0143 In vivo study of adenvirus mediated transgenic HIF-1  and its protective effects on cardiac function in experimental myocardial infarction

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A46-A46
Author(s):  
L. Dongye ◽  
Y. Yan ◽  
L. Yina ◽  
L. Chuang ◽  
Z. Hong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Experimental Myocardial Infarction ◽  
In Vivo Study ◽  
Protective Effects

scholarly journals Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

2021 ◽  
Vol 28 ◽  
pp. 101162
Author(s):  
Kun Zhang ◽  
Melissa M. Cremers ◽  
Stephan Wiedemann ◽  
David M. Poitz ◽  
Christian Pfluecke ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Experimental Myocardial Infarction ◽  
Calpain Activity ◽  
Temporal Regulation ◽  
Spatio Temporal

scholarly journals Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain

2021 ◽  
Vol 7 ◽  
Author(s):  
Hélène David ◽  
Aurore Ughetto ◽  
Philippe Gaudard ◽  
Maëlle Plawecki ◽  
Nitchawat Paiyabhroma ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Tissue ◽  
Myocardial Strain ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Experimental Myocardial Infarction ◽  
Diagnostic Modality ◽  
Peripheral Organs ◽  
The Brain

Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes in vascular oxygen saturation (sO2) occurring over time after experimental MI in multiple peripheral organs and in the brain.Methods and Results: Experimental MI was obtained in BALB/c mice by permanent ligation of the left anterior descending artery. PA imaging (Vevo LAZR-X) allowed tracking mouse-specific sO2 kinetics in the cardiac left ventricular (LV) anterior wall, brain, kidney, and liver at 4 h, 1 day, and 7 days post-MI. Here we reported a correlation between LV sO2 and longitudinal anterior myocardial strain after MI (r = −0.44, p < 0.0001, n = 96). Acute LV dysfunction was associated with global hypoxia, specifically a decrease in sO2 level in the brain (−5.9%), kidney (−6.4%), and liver (−7.3%) at 4 and 24 h post-MI. Concomitantly, a preliminary examination of capillary NG2DsRed pericytes indicated cell rarefication in the heart and kidney. While the cardiac tissue was persistently impacted, sO2 levels returned to pre-MI levels in the brain and in peripheral organs 7 days after MI.Conclusions: Collectively, our data indicate that experimental MI elicits precise trajectories of vascular hypoxia in peripheral organs and in the brain. PA imaging enabled the synchronous tracking of oxygenation in multiple organs and occurring post-MI, potentially enabling a translational diagnostic modality for the identification of vascular modifications in this disease setting.

Scintigraphic Detection of Experimental Myocardial Infarction with 99mTc-Heparin in the Dog

1985 ◽  
Vol 24 (03) ◽  
pp. 111-114 ◽  
Author(s):  
P. Kafka ◽  
J. Kubíček ◽  
J. Vižda ◽  
Y. Mazurová ◽  
F. Duška
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Left Coronary Artery ◽  
Background Activity ◽  
Experimental Myocardial Infarction ◽  
The Other ◽  
Tissue Samples ◽  
Ramus Interventricularis Anterior

SummaryExperimental infarctions were produced in 12 dogs by ligation of the Ramus interventricularis anterior of the left coronary artery, and their uptake of 99mTc-heparin was measured 7, 24 and 48 h as well as 7 days thereafter by recording an in vivo chest scintigram 4 h after intravenous injection of the compound. The dogs were subsequently killed, the heart removed and an in vitro scintigram obtained. Finally, the uptake of the compound was measured in tissue samples. The results indicate that 99mTc-heparin is accumulated in lesions which are not older than 24 h. At the other points in time uptake is low but even 24-h old lesions cannot be demonstrated reliably. The results are impaired by the high blood activity on the cardiac chambers and by the background activity of the lungs. In general, 99mTc-heparin has less useful properties than the more frequently employed 99mTc-pyrophosphate so that a change of procedure is not to be recommended.

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