Epilepsy and drug-resistant epilepsy in children with cerebral palsy: A retrospective observational study

2020 ◽  
Vol 112 ◽  
pp. 107357 ◽  
Author(s):  
Fatma Hanci ◽  
Sevim Türay ◽  
Mustafa Dilek ◽  
Nimet Kabakuş
Keyword(s):  
Cerebral Palsy ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Drug Resistant ◽  
Children With Cerebral Palsy ◽  
Drug Resistant Epilepsy

Prediction of Drug-Resistant Epilepsy in Children With Cerebral Palsy

2019 ◽  
Vol 35 (3) ◽  
pp. 187-194
Author(s):  
Itay Tokatly Latzer ◽  
Amit Blumovich ◽  
Liora Sagi ◽  
Shimrit Uliel-Sibony ◽  
Aviva Fattal-Valevski
Keyword(s):  
Cerebral Palsy ◽  
Chart Review ◽  
Operating Characteristic ◽  
Seizure Control ◽  
Retrospective Chart Review ◽  
Clinical Settings ◽  
Drug Resistant ◽  
Children With Cerebral Palsy ◽  
Drug Resistant Epilepsy ◽  
Electroencephalogram Eeg

Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.

scholarly journals The Occurrence of Seizure Clusters in Patients With Epilepsy Is Partly Determined by Epilepsy Severity: A Single-Center Retrospective Observational Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Rui Zhong ◽  
Qingling Chen ◽  
Xinyue Zhang ◽  
Weihong Lin
Keyword(s):  
Logistic Regression ◽  
Observational Study ◽  
Regression Models ◽  
Final Analysis ◽  
Retrospective Observational Study ◽  
Logistic Regression Models ◽  
History Of ◽  
Drug Resistant Epilepsy ◽  
The Individual ◽  
Patients With Epilepsy

Purpose: This retrospective observational study aimed to investigate the self-reported prevalence of seizure clusters (SCs) in patients with epilepsy (PWE) and its relationship with clinical characteristics.Methods: We retrospectively analyzed data from consecutive PWE from our hospital in northeastern China. Data were collected from the databank of a tertiary epilepsy center. Logistic regression models were employed to investigate the relationships between the individual patient demographic/clinical variables and the occurrence of SC.Results: In total, 606 consecutive PWE were included in the final analysis, and 268 (44.2%) patients experienced at least one seizure cluster. In multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002–1.027; p = 0.02), seizure frequency (OR: 2.08; 95% CI: 1.555–2.783; p < 0.001), multiple seizure types (OR: 5.111; 95% CI: 1.737–15.043; p = 0.003), number of current anti-seizure medications (ASM) (OR: 1.533; 95% CI: 1.15–2.042; p = 0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159–3.407; p = 0.013), and a history of status epilepticus (OR: 1.903; 95% CI: 1.24–2.922; p = 0.003) were independent variables associated with a history of SC in PWE.Conclusion: Seizure clusters (SCs) are common occurrences at our study center. The occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.

scholarly journals Epidemiology of drug-resistant tuberculosis in Chongqing, China: a retrospective observational study from 2010 to 2017

2019 ◽  
Author(s):  
Bo Wu ◽  
Ya Yu ◽  
Changting Du ◽  
Ying Liu ◽  
Daiyu Hu
Keyword(s):  
Observational Study ◽  
Treatment Success ◽  
Multidrug Resistant ◽  
Policy Support ◽  
Retrospective Observational Study ◽  
Drug Resistant ◽  
Notification Rate ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb

AbstractChina is one of the top 30 countries with high multidrug-resistant tuberculosis (MDR-TB) and rifampin-resistant tuberculosis (RR-TB) burden. Chongqing is a southwest city of China with a large rural population. A retrospective observational study has been performed based on routine tuberculosis (TB) surveillance data in Chongqing from 2010 to 2017. The MDR/RR-TB notification rate increased from 0.03 cases per 100,000 population in 2010 to 2.09 cases per 100,000 population in 2017. The extensively drug-resistant TB (XDR-TB) notification rate has increased to 0.09 cases per 100,000 population in 2017. There was a decreasing detection gap between the number of notified MDR/RR-TB cases and the estimate number of MDR/RR-TB cases among all notified TB cases. The treatment success rate of MDR/RR-TB was 50.66% in this period. The rate of MDR/RR-TB in new TB cases was 6.23%, and this rate in previously treated TB cases was 32.7%. Despite the progress achieved, the prevalence of MDR/RR-TB was still high facing challenges including detection gaps, the regional disparity, and the high risk for MDR/RR-TB in elderly people and farmers. Sustained government financing and policy support should be guaranteed in the future.

scholarly journals Integrated Rehabilitation for Children with Cerebral palsy: A Prospective Observational Study

2021 ◽  
Vol 42 (4) ◽  
pp. 60-74
Author(s):  
Hye-Yoon Lee ◽  
Young-Ju Yun ◽  
Yong-Beom Shin ◽  
Soo-Yeon Kim ◽  
Jun-hee Han ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Observational Study ◽  
Motor Function ◽  
Prospective Observational Study ◽  
Health Problems ◽  
System Level ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Treatment Type ◽  
Children With Cerebral Palsy

Objectives: This study aimed to analyse: 1) the clinical effectiveness and safety of traditional Korean Medicine (TKM) and frequency of TKM therapies used and their relationship with conventional treatments.Methods: This prospective observational study enrolled children with cerebral palsy (CP) aged 6-78 months (n=126). The children who used herbal medication for >30 days or acupuncture treatment >12 sessions within 6 months were defined as the integrated rehabilitation (IR) group; the remaining participants were included in the conventional rehabilitation (CR) group.Results: Changes in the Gross Motor Function Measure-66 (GMFM-66) were greater in the IR group (6.4±6.1) than in the CR group (4.6±5.8). The reduction in the number of other health problems was greater in the IR group than in the CR group. The GMFM-66 improvement was greatest in gross motor function classification system level 1. There was no between-group difference in the frequency of rehabilitation therapy (10.9±6.6 and 12.0±9.9 in the IR and CR groups, respectively).Conclusion: TKM may offer additional benefits in terms of the GMFM-66 score and other health problems. However, there is a need for further randomized controlled trials involving a restricted CP type and a controlled treatment type and intensity to confirm these findings.

Generator replacement with cardiac-based VNS device in children with drug-resistant epilepsy: An observational study

2020 ◽  
Vol 167 ◽  
pp. 106431
Author(s):  
Aris Hadjinicolaou ◽  
Puneet Jain ◽  
Ravindra Arya ◽  
Celie Roth ◽  
Robyn Whitney ◽  
...  
Keyword(s):  
Observational Study ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy ◽  
Generator Replacement

scholarly journals An observational study to determine the status of serum and RBC folate in drug resistant epileptic children at a tertiary care centre in Western Rajasthan, India

2020 ◽  
Vol 7 (7) ◽  
pp. 1554
Author(s):  
Bindu Deopa ◽  
Bhawna Chaudhary ◽  
Ashish Gupta
Keyword(s):  
Observational Study ◽  
Tertiary Care ◽  
Folic Acid Supplementation ◽  
Serum Folate ◽  
Healthy Children ◽  
Drug Resistant ◽  
Tertiary Care Centre ◽  
Epileptic Children ◽  
The Status ◽  
Drug Resistant Epilepsy

Background: Drug resistant epilepsies constitute about 10-20% of childhood epilepsies and treated with higher doses and multiple AEDs. AEDs increases folate metabolism by enzyme induction thus causes deficiency of folic acid.Objective was to evaluate the effect on serum and RBC folate in children having drug resistant epilepsy.Methods: In a prospective observational study 83 drug resistant epileptic children of age 6months to 180 months fulfilled the inclusion criteria enrolled in study, from Oct 2014 to Nov 2016 for a period of two years. Serum and RBC folate levels were done in these children. Epileptic children already receiving folic acid supplementation/treatment were excluded from the study. Children with serum folate level <5ng/ml and RBC folate <280ng/ml was considered as folate deficiency.Results: Total 83 children had drug resistant epilepsy (defined by ILAE). Mean age of children with drug resistant epilepsy was 71.39±49.76 months. 71.08 % were male and 28.91% were female. Mean serum folate in these children was 7.75±2.77 ng/ml and RBC folate 381.63±164.54 ng/ml which was significantly lower as compared to healthy children or epileptic not receiving AEDs. 14.45 % children in drug resistant epilepsy had serum folate <5ng/ml while 20.89% were found to be RBC folate deficient (RBC level <280ng/ml).Conclusions: Antiepileptic drugs are associated with lower blood folate status which deteriorates further with increasing number and doses of AEDs in drug resistant patients. Therefore blood folate monitoring should be done in all children on AEDs on regular intervals and should be considered in the etiologic differentials of drug resistant epilepsy. 

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