ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells

2007 ◽  
Vol 313 (3) ◽  
pp. 473-485 ◽  
Author(s):  
Anne Beghin ◽  
Stephane Honore ◽  
Celine Messana ◽  
Eva-Laure Matera ◽  
Jennifer Aim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Microtubule Dynamics ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals Silencing of Tubulin Binding Cofactor C Modifies Microtubule Dynamics and Cell Cycle Distribution and Enhances Sensitivity to Gemcitabine in Breast Cancer Cells

2011 ◽  
Vol 10 (2) ◽  
pp. 303-312 ◽  
Author(s):  
Rouba Hage-Sleiman ◽  
Stéphanie Herveau ◽  
Eva-Laure Matera ◽  
Jean-Fabien Laurier ◽  
Charles Dumontet
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Microtubule Dynamics ◽  
Cell Cycle Distribution ◽  
Tubulin Binding

scholarly journals PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1539 ◽  
Author(s):  
Sobczak ◽  
Pitt ◽  
Spickett ◽  
Robaszkiewicz
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Dna Repair Genes ◽  
Adp Ribosylation ◽  
Repair Genes

BRG1, an active subunit of the SWI/SNF chromatin-remodeling complex, enables the EP300-dependent transcription of proliferation and DNA repair genes from their E2F/CpG-driven promoters in breast cancer cells. In the current study, we show that BRG1–EP300 complexes are accompanied by poly-ADP-ribose polymerase 1 (PARP1), which emerges as the functional component of the promoter-bound multiprotein units that are capable of controlling gene expression. This enzyme is co-distributed with BRG1 at highly acetylated promoters of genes such as CDK4, LIG1, or NEIL3, which are responsible for cancer cell growth and the removal of DNA damage. ADP-ribosylation is necessary to maintain active transcription, since it ensures an open chromatin structure that allows high acetylation and low histone density. PARP1-mediated modification of BRG1 and EP300 does not affect the association of enzymes with gene promoters; however, it does activate EP300, which acetylates nucleosomes, leading to their eviction by BRG1, thus allowing mRNA synthesis. Although PARP1 was found at BRG1 positive/H3K27ac negative promoters of highly expressed genes in a transformed breast cancer cell line, its transcriptional activity was limited to genes simultaneously controlled by BRG1 and EP300, indicating that the ADP-ribosylation of EP300 plays a dominant role in the regulation of BRG1–EP300-driven transcription. In conclusion, PARP1 directs the transcription of some proliferation and DNA repair genes in breast cancer cells by the ADP-ribosylation of EP300, thereby causing its activation and marking nucleosomes for displacement by BRG1. PARP1 in rapidly dividing cells facilitates the expression of genes that confer a cancer cell phenotype. Our study shows a new mechanism that links PARP1 with the removal of DNA damage in breast cancer cells via the regulation of BRG1–EP300-dependent transcription of genes involved in DNA repair pathways.

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells

Effect of oxidative stress on rhodamine123 uptake in breast cancer cells

2020 ◽  
Author(s):  
Renee Suzich ◽  
Troy K. Townsend
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Cells ◽  
Breast Cancer Cells

Antiproliferative and apoptotic activities of extracts from carob tree (Ceratonia siliqua L.) in MDA-MB-231 human breast cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
L Custódio ◽  
E Fernandes ◽  
AL Escapa ◽  
S López-Avilés ◽  
A Fajardo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Ceratonia Siliqua ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Carob Tree ◽  
Ceratonia Siliqua L

Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay

2011 ◽  
Vol 71 (08) ◽  
Author(s):  
FA Taran ◽  
A Hartkopf ◽  
H Seeger ◽  
M Zwirner ◽  
D Wallwiener ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Primary Breast Cancer ◽  
Breast Cancer Cells ◽  
Chemosensitivity Assay

Asperjinone, a norneolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from Aspergillus terreus

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
WY Liao ◽  
CN Shen ◽  
LH Lin ◽  
YL Yang ◽  
HY Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Aspergillus Terreus
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