scholarly journals 177. A Novel Class of Cationic Amphiphiles for Airway Gene Delivery

2006 ◽  
Vol 13 ◽  
pp. S68-S69
Author(s):  
Keun-Sik Kim ◽  
Qun Li ◽  
Takeshi Suda ◽  
Dexi Liu
Keyword(s):  
Gene Delivery ◽  
Cationic Amphiphiles

scholarly journals Bis‐Thioether‐Containing Lipid Chains in Cationic Amphiphiles: Physicochemical Properties and Applications in Gene Delivery

ChemPhysChem ◽  
2019 ◽  
Vol 20 (17) ◽  
pp. 2187-2194
Author(s):  
Amal Bouraoui ◽  
Rosy Ghanem ◽  
Mathieu Berchel ◽  
Véronique Vié ◽  
Yann Le Guen ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Physicochemical Properties ◽  
Cationic Amphiphiles

scholarly journals Lipophilic Polyamines as Promising Components of Liposomal Gene Delivery Systems

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 920
Author(s):  
Pavel A. Puchkov ◽  
Michael A. Maslov
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Mutual Influence ◽  
Structural Components ◽  
Delivery Vehicle ◽  
Safe Delivery ◽  
Cationic Amphiphiles ◽  
Liposomal Formulations ◽  
Delivery Efficiency

Gene therapy requires an effective and safe delivery vehicle for nucleic acids. In the case of non-viral vehicles, including cationic liposomes, the structure of compounds composing them determines the efficiency a lot. Currently, cationic amphiphiles are the most frequently used compounds in liposomal formulations. In their structure, which is a combination of hydrophobic and cationic domains and includes spacer groups, each component contributes to the resulting delivery efficiency. This review focuses on polycationic and disulfide amphiphiles as prospective cationic amphiphiles for gene therapy and includes a discussion of the mutual influence of structural components.

Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery

2020 ◽  
Vol 18 (2) ◽  
pp. 337-345
Author(s):  
Amal Bouraoui ◽  
Rosy Ghanem ◽  
Mathieu Berchel ◽  
Laure Deschamps ◽  
Véronique Vié ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Amphiphiles ◽  
Self Organized ◽  
High Gene

Cationic amphiphiles featuring ramified lipid chains self-organized in water as inverted hexagonal aggregates. They demonstrated high gene delivery efficiencies.

scholarly journals Substitution of unsaturated lipid chains by thioether-containing lipid chains in cationic amphiphiles: physicochemical consequences and application for gene delivery

2019 ◽  
Vol 17 (14) ◽  
pp. 3609-3616 ◽  
Author(s):  
Amal Bouraoui ◽  
Mathieu Berchel ◽  
Rosy Ghanem ◽  
Véronique Vié ◽  
Gilles Paboeuf ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Unsaturated Lipid ◽  
Cationic Amphiphiles

New thioether-containing amphiphiles were designed, characterized and applied for gene delivery.

α-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery

2018 ◽  
Vol 16 (16) ◽  
pp. 2932-2946 ◽  
Author(s):  
Venkanna Muripiti ◽  
Hari Krishnareddy Rachamalla ◽  
Rajkumar Banerjee ◽  
Srilakshmi. V. Patri
Keyword(s):  
Gene Delivery ◽  
Ph Sensitive ◽  
Endosomal Escape ◽  
Cationic Amphiphiles

Endosomal escape is one of the barriers for the efficient liposomal gene delivery.

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine

Rapid Optimization of Gene Delivery by Parallel End-modification of Poly(β-amino ester)s

2007 ◽  
Author(s):  
Gregory T Zugates ◽  
Weidan Peng ◽  
Andreas Zumbuehl ◽  
Siddharth Jhunjhunwala ◽  
Yu-Hung Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Amino Ester
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