Bis‐Thioether‐Containing Lipid Chains in Cationic Amphiphiles: Physicochemical Properties and Applications in Gene Delivery

Graphene, a two-dimensional nanomaterial reported for the first time in 2004, has been widely investigated for its novel physicochemical properties and potential applications. This review selectively summarizes the recent progress in using graphene-based nanomaterials for various biomedical applications. In particular, graphene-based sensors and biosensors, which are classified according to different sensing mechanisms and targets, are thoroughly discussed. Next, the utilization of graphene as nanocarriers for drug delivery, gene delivery and nanomedicine are demonstrated for potential cancer therapies. Finally, other graphene-based matrices, nanoscaffolds, and composites, which are used in bioapplications, are presented, followed by conclusions and perspective.

Download Full-text

Physicochemical Properties of pDNA/Chitosan Complexes as Gene Delivery Systems

Current Drug Discovery Technologies ◽

10.2174/157016311798109362 ◽

2011 ◽

Vol 8 (4) ◽

pp. 329-339 ◽

Cited By ~ 2

Author(s):

Kenji Hagiwara ◽

Riany Anastasia ◽

Mitsuhiro Nakata ◽

Toshinori Sato

Keyword(s):

Gene Delivery ◽

Physicochemical Properties ◽

Delivery Systems

Download Full-text

Lipophilic Polyamines as Promising Components of Liposomal Gene Delivery Systems

Pharmaceutics ◽

10.3390/pharmaceutics13060920 ◽

2021 ◽

Vol 13 (6) ◽

pp. 920

Author(s):

Pavel A. Puchkov ◽

Michael A. Maslov

Keyword(s):

Gene Therapy ◽

Gene Delivery ◽

Nucleic Acids ◽

Mutual Influence ◽

Structural Components ◽

Delivery Vehicle ◽

Safe Delivery ◽

Cationic Amphiphiles ◽

Liposomal Formulations ◽

Delivery Efficiency

Gene therapy requires an effective and safe delivery vehicle for nucleic acids. In the case of non-viral vehicles, including cationic liposomes, the structure of compounds composing them determines the efficiency a lot. Currently, cationic amphiphiles are the most frequently used compounds in liposomal formulations. In their structure, which is a combination of hydrophobic and cationic domains and includes spacer groups, each component contributes to the resulting delivery efficiency. This review focuses on polycationic and disulfide amphiphiles as prospective cationic amphiphiles for gene therapy and includes a discussion of the mutual influence of structural components.

Download Full-text

Nano-Scale Gene Delivery Systems: Current Technology, Obstacles, and Future Directions

Current Medicinal Chemistry ◽

10.2174/0929867325666180108100723 ◽

2018 ◽

Vol 25 (21) ◽

pp. 2448-2464 ◽

Cited By ~ 5

Author(s):

Antonio Garcia-Guerra ◽

Thomas L. Dunwell ◽

Sonia Trigueros

Keyword(s):

Gene Delivery ◽

Physicochemical Properties ◽

Genetic Material ◽

Delivery Systems ◽

Bibliographic Databases ◽

Central Component ◽

Medical Needs ◽

Advantages And Disadvantages ◽

Nano Scale

Within the different applications of nanomedicine currently being developed, nanogene delivery is appearing as an exciting new technique with the possibility to overcome recognised hurdles and several biological and medical needs. The central component of all delivery systems is the requirement for the delivery of genetic material into cells, and for them to eventually reside in the nucleus where their desired function will be exposed. However, genetic material does not passively enter cells; thus, a delivery system is necessary. The emerging field of nano-gene delivery exploits the use of new materials and the properties that arise at the nanometre-scale to produce delivery vectors that can effectively deliver genetic material into a variety of different types of cells. The novel physicochemical properties of the new delivery vectors can be used to address the current challenges existing in nucleic acid delivery in vitro and in vivo. While there is a growing interest in nanostructure-based gene delivery, the field is still in its infancy, and there is yet much to discover about nanostructures and their physicochemical properties in a biological context. We carried out an organised and focused search of bibliographic databases. Our results suggest that despite new breakthroughs in nanostructure synthesis and advanced characterization techniques, we still face many barriers in producing highly efficient and non-toxic delivery systems. In this review, we overview the types of systems currently used for clinical and biomedical research applications along with their advantages and disadvantages, as well as discussing barriers that arise from nano-scale interactions with biological material. In conclusion, we hope that by bringing the far reaching multidisciplinary nature of nano-gene delivery to light, new targeted nanotechnology-bases strategies are developed to overcome the major challenges covered in this review.

Download Full-text

Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery

Organic & Biomolecular Chemistry ◽

10.1039/c9ob02381j ◽

2020 ◽

Vol 18 (2) ◽

pp. 337-345

Author(s):

Amal Bouraoui ◽

Rosy Ghanem ◽

Mathieu Berchel ◽

Laure Deschamps ◽

Véronique Vié ◽

...

Keyword(s):

Gene Delivery ◽

Cationic Amphiphiles ◽

Self Organized ◽

High Gene

Cationic amphiphiles featuring ramified lipid chains self-organized in water as inverted hexagonal aggregates. They demonstrated high gene delivery efficiencies.

Download Full-text