CRISPR-Cas12a with an oAd Induces Precise and Cancer-Specific Genomic Reprogramming of EGFR and Efficient Tumor Regression

The effects of radioimmunotherapy were tested in xenografts of 2 different human pancreatic carcinomas comparing the intravenous and intratumoral application. On principle, intravenous injections of high doses of 131l-anti- Ca 19-9 or -BW 494/32 may inhibit tumor growth. In view of the low direct radiation dose (360-2100 rad), however, other factors than direct toxic effects have to be discussed, e. g. systemic effects due to the high whole-body irradiation. Intratumoral application, however, may induce tumor regression or growth inhibition due to the high local irradiation dose. Consequently, this treatment modality might be of clinical value at least in some patients.

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Association between gastrin-releasing peptide receptor expression based on Ga-68-RM2-PET and histopathological tumor regression after neoadjuvant chemotherapy in primary breast cancer

10.1055/s-0039-1683576 ◽

2019 ◽

Author(s):

C Stoykow ◽

J Asberger ◽

H Maecke ◽

P Bronsert ◽

M Werner ◽

...

Keyword(s):

Breast Cancer ◽

Neoadjuvant Chemotherapy ◽

Primary Breast Cancer ◽

Tumor Regression ◽

Receptor Expression ◽

Peptide Receptor ◽

Gastrin Releasing Peptide

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RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer

Case Medical Research ◽

10.31525/ct1-nct04273451 ◽

2020 ◽

Author(s):

Keyword(s):

Artificial Intelligence ◽

Rectal Cancer ◽

Tumor Regression ◽

Locally Advanced ◽

Advanced Rectal Cancer ◽

Locally Advanced Rectal Cancer ◽

Regression Grading

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Gamma knife radiosurgery for uveal melanomas: an 8-year experience

Journal of Neurosurgery ◽

10.3171/jns.2000.93.supplement_3.0184 ◽

2000 ◽

Vol 93 (supplement_3) ◽

pp. 184-188 ◽

Cited By ~ 52

Author(s):

Gerald Langmann ◽

Gerhard Pendl ◽

Georg Papaefthymiou ◽

Helmuth Guss ◽

Keyword(s):

Gamma Knife ◽

Ciliary Body ◽

Tumor Regression ◽

Gamma Knife Radiosurgery ◽

Neovascular Glaucoma ◽

Content Type ◽

Prescription Dose ◽

The Mean ◽

Fine Print ◽

Uveal Melanomas

Object. The authors report their experience using gamma knife radiosurgery (GKS) to treat uveal melanomas. Methods. Between 1992 and 1998, 60 patients were treated with GKS at a prescription dose between 45 Gy and 80 Gy. The mean diameter of the tumor base was 12.2 mm (range 3–22 mm). The mean height of the tumor prominence was 6.7 mm (range 3–12 mm). The eye was immobilized. The follow-up period ranged from 16 to 94 months. Tumor regression was achieved in 56 (93%) of 60 patients. There were four recurrences followed by enucleation. The severe side effect of neovascular glaucoma developed in 21 (35%) patients in a high-dose group with larger tumors and in proximity to the ciliary body. A reduction in the prescription dose to 40 Gy or less and excluding treatment to tumors near the ciliary body decreased the rate of glaucoma without affecting the rate of tumor control. Conclusions. Gamma knife radiosurgery at a prescription dose of 45 Gy or more can achieve tumor regression in 85% of the uveal melanomas treated. Neovascular glaucoma can develop in patients when using this dose in tumors near the ciliary body. It is advised that such tumors be avoided and that the prescription dose be reduced to 40 Gy.

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