Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study

Abstract Wiskott-Aldrich syndrome (WAS) thrombocytopenia is frequently improved by splenectomy, although the mechanism of the thrombocytopenia and its resolution are unknown. Previous studies in two patients have shown that mean platelet volume, which is characteristically reduced in WAS, increased along with platelet count postsplenectomy. Additional studies in a limited number of patients have also demonstrated that platelet- associated immunoglobulin G (PAIgG) is elevated presplenectomy, but to date no postsplenectomy data have been reported. The present study was performed to more fully evaluate the effect of splenectomy on platelet volume and PAIgG in WAS. Before splenectomy, mean platelet volume was reduced but platelet size was broadly distributed with substantial overlap of the normal range. PAIgG was significantly elevated in 13 of 14 presplenectomy WAS patients (means = 78.9 fg per platelet) and fell to normal levels postoperatively (means = 4.0 fg per platelet). Platelet count and clinical status improved postsplenectomy, and mean platelet volume and platelet volume distribution returned to the normal range. WAS subjects who relapsed with recurrent thrombocytopenia redeveloped elevated PAIgG but maintained normal platelet size. The spleen appears to play a critical role in a process that may be immunologically mediated and results in reduced platelet size.

Download Full-text

Combined Use of Mean Platelet Volume/Platelet Count Ratio and Platelet Distribution Width to Distinguish Between Patients with Nasopharyngeal Carcinoma, Those with Benign Tumors of the Nasopharynx, and Healthy Subjects

Cancer Management and Research ◽

10.2147/cmar.s226050 ◽

2019 ◽

Vol Volume 11 ◽

pp. 10375-10382

Author(s):

Xuan Zhang ◽

Yuan-yuan Qin ◽

Min Chen ◽

Yang-yang Wu ◽

Fa-quan Lin

Keyword(s):

Platelet Count ◽

Nasopharyngeal Carcinoma ◽

Mean Platelet Volume ◽

Healthy Subjects ◽

Benign Tumors ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Count Ratio ◽

Combined Use

Download Full-text

Studies on Reference Intervals for Platelet Counts in Three Cities in China and one in Japan

Thrombosis and Haemostasis ◽

10.1055/s-0037-1613162 ◽

2002 ◽

Vol 88 (07) ◽

pp. 111-114 ◽

Cited By ~ 3

Author(s):

Changgeng Ruan ◽

Yun Wu ◽

Tokuhiro Okada ◽

Shigemi Motoi ◽

Tamiaki Kondo ◽

...

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Healthy Subjects ◽

Hematological Parameters ◽

Reference Interval ◽

Reference Intervals ◽

Sichuan Province ◽

Jiangsu Province ◽

Platelet Volume ◽

Platelet Counts

SummaryHematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. The reference interval for platelet count of subjects aged between 18 and 60 years was 60-259 × 109/L in Suzhou and 52–202 × 109/L in Chengdu, and subjects with platelet counts of 100 × 109/L or less accounted for about 30% of the subjects examined in these cities. The reference intervals in Harbin and Kobe were within the range of 150–350 × 109/L, and no subject having a platelets count of 100 × 109/L or less was detected. Mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, and the reference intervals for MPV in Chengdu and Suzhou were higher than those in Harbin and Kobe.

Download Full-text

Prognostic value of mean platelet volume on tinnitus

The Journal of Laryngology & Otology ◽

10.1017/s0022215115003254 ◽

2015 ◽

Vol 130 (2) ◽

pp. 162-165 ◽

Cited By ~ 5

Author(s):

O Kemal ◽

T Müderris ◽

F Başar ◽

G Kutlar ◽

F Gül

Keyword(s):

Mean Platelet Volume ◽

Healthy Subjects ◽

Clinical Findings ◽

University Hospital ◽

Control Group ◽

Study Group ◽

Pathophysiological Mechanism ◽

Platelet Volume ◽

Significant Difference ◽

Healthy Control

AbstractObjective:This study aimed to determine whether there was any relationship between tinnitus and mean platelet volume.Methods:This retrospective study was conducted between January 2013 and January 2014 in Ankara Atatürk Hospital and Ondokuz Mayıs University Hospital, Turkey, on a study group of 86 patients with tinnitus and a control group of 84 healthy subjects. Mean platelet volume was recorded and comparisons were made between the two groups.Results:Mean (± standard deviation) platelet volume was 7.67 ± 0.83 μm3 in the study group and 7.28 ± 0.56 μm3 in the control group. There was a statistically significant difference in mean platelet volume between the tinnitus patients and the healthy subjects (p < 0.05).Conclusion:The clinical findings indicated that tinnitus patients had a higher mean platelet volume than the healthy control subjects; however, the pathophysiological mechanism remains unclear.

Download Full-text

Relevance of pretransfusion incubation of platelets at 37 degrees C

Blood ◽

10.1182/blood.v80.6.1599.bloodjournal8061599 ◽

1992 ◽

Vol 80 (6) ◽

pp. 1599-1602

Author(s):

RA de Vries ◽

JG Gerritsen ◽

M de Bruin ◽

JJ Marx ◽

HC Hart ◽

...

Keyword(s):

Beneficial Effect ◽

Mean Platelet Volume ◽

Healthy Subjects ◽

The Other ◽

Platelet Concentrates ◽

Platelet Volume ◽

Label Technique ◽

The Mean ◽

Initial Recovery ◽

Dual Label

The effect of pretransfusion incubation of platelets at 37 degrees C was assessed because of the controversial reports about its relevance. A dual-label technique (111indium and 114mindium) was applied in 10 healthy subjects receiving warmed and unwarmed autologous platelets simultaneously. Fresh platelet concentrates were infused into five subjects, whereas the other five subjects received stored platelet concentrates. The mean platelet volume decreased in all platelet concentrates during incubation, reflecting the restoration of the discoid shape of the platelets. The mean decrease was 0.35 fL (P = .003). However, the initial recovery and the mean platelet life-span were not improved by this procedure. It was concluded that there is no evidence that brief warming of platelets has any beneficial effect on platelet viability in healthy volunteers.

Download Full-text

Effects of biological variations on platelet count in healthy subjects in China

Thrombosis and Haemostasis ◽

10.1160/th03-05-0276 ◽

2004 ◽

Vol 91 (02) ◽

pp. 367-372 ◽

Cited By ~ 18

Author(s):

Jing Yang ◽

Xiaojun Lu ◽

Tokuhiro Okada ◽

Tamiaki Kondo ◽

Changgeng Ruan ◽

...

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Healthy Subjects ◽

Bleeding Time ◽

Platelet Volume ◽

Platelet Counts ◽

Normal Platelet Count ◽

Normal Platelet ◽

Low Platelet Count ◽

The Mean

SummaryThe effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52∼202 X 109/L) and Suzhou (60∼259 X 109/L) than in Harbin (154∼348 X 109/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.8∼15.6 fl) and Suzhou (10.9∼15.8 fl) than in Harbin (9.5∼12.9 fl) (p < 0.0001). Platelet counts were significantly higher in summer (73∼289 X 109/L) than in winter (52∼202 X 109/L) (p <0.0001), but the MPV values were lower in summer (11.2∼14.7 fl) than in winter (11.8∼15.6 fl) (p <0.05) in Chengdu. Platelet associated immunoglobulin (PA-IgG) in Chengdu was revealed to be significantly higher in the low platelet count group (<150 X 109/L, 13.5 ± 7.1 ng/107 PLT) than in the normal platelet count group (≥150 X 109/L, 8.3 ± 2.7 ng/107 PLT)(p <0.0001). Similar results were observed in Suzhou for the reticulated platelet ratio, which was significantly higher in the low platelet count group (19.5 ± 7.1%) than in the normal platelet count group (11.6 ± 2.7%)(p <0.01). The bleeding time in Chengdu showed a significantly longer time in the low platelet count group (8.6 ± 2.3 min) than in the normal platelet count group (6.0 ± 1.2 min)(p <0.01). With regard to the effects of lipids on platelet counts, the HDL values were significantly higher in the normal platelet count group (1.60 ± 0.76 mmol/L) than the low platelet count group (1.23 ± 0.31 mmol/L) (p <0.01); but no significant differences in cholesterol and triglycerides values between the normal and low platelet count groups (p >0.05) were recorded. These findings suggest that the platelet counts could be greatly influenced in healthy subjects by biological variations such as geographical, seasonal, and lipid variations.

Download Full-text