Prognostic value of mean platelet volume on tinnitus

AbstractObjective:This study aimed to determine whether there was any relationship between tinnitus and mean platelet volume.Methods:This retrospective study was conducted between January 2013 and January 2014 in Ankara Atatürk Hospital and Ondokuz Mayıs University Hospital, Turkey, on a study group of 86 patients with tinnitus and a control group of 84 healthy subjects. Mean platelet volume was recorded and comparisons were made between the two groups.Results:Mean (± standard deviation) platelet volume was 7.67 ± 0.83 μm3 in the study group and 7.28 ± 0.56 μm3 in the control group. There was a statistically significant difference in mean platelet volume between the tinnitus patients and the healthy subjects (p < 0.05).Conclusion:The clinical findings indicated that tinnitus patients had a higher mean platelet volume than the healthy control subjects; however, the pathophysiological mechanism remains unclear.

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The Mean Platelet Volume in Patients with Retinal Vein Occlusion

Journal of Ophthalmology ◽

10.1155/2013/236371 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 9

Author(s):

Alparslan Şahin ◽

Muhammed Şahin ◽

Harun Yüksel ◽

Fatih Mehmet Türkcü ◽

Yasin Çınar ◽

...

Keyword(s):

Retinal Vein Occlusion ◽

Mean Platelet Volume ◽

Control Group ◽

Platelet Volume ◽

Control Subjects ◽

Vein Occlusion ◽

Significant Difference ◽

Healthy Control ◽

The Mean ◽

And Control

Background. The aim of this study was to investigate the mean platelet volume (MPV) of patients with retinal vein occlusion (RVO).Methods. Hundred and ninty-three patients with the diagnosis of RVO and 83 healthy control subjects were included in this retrospective study. Retinal vein occlusion was diagnosed based on clinical examination. All patients and control subjects underwent complete ocular examination. MPV, hematocrit, hemoglobin, and platelet count of the participants were recorded. The data of patients with RVO was compared with the control subjects.Results. Patients with RVO had significantly higher MPV values ( fL) compared with the control subjects ( fL) (). No significant difference was found in platelet counts between RVO group and the control group ( 109/L and 109/L, resp., ), Mean platelet volume was an independent predictor of RVO (odds ratio (OR) = 1.43; 95% confidence interval (CI) = 1.09–1.89; ).Conclusion. Our results demonstrated that the MPV values were significantly higher in patients with RVO, suggesting that larger platelets may contribute to the pathogenesis of the RVOs.

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Vitamin K2 Supplementation Does Not Affect Vitamin K-Dependent Coagulation Factors Activity in Healthy Subjects: A Pilot Study

Current Developments in Nutrition ◽

10.1093/cdn/nzaa067_070 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1843-1843

Author(s):

Jing Tan ◽

Ruijun Ren ◽

Dan Xu

Keyword(s):

Vitamin K ◽

Healthy Subjects ◽

Coagulation Factors ◽

Vitamin K2 ◽

Control Group ◽

Healthy Population ◽

Thrombin Time ◽

Healthy Individuals ◽

Significant Difference ◽

Healthy Control

Abstract Objectives Vitamin K is generally regarded as a procoagulant drug with physicians, concerns have been raised about its effects on hemostasis in the healthy population. We aimed to investigate whether vitamin K2 affects activities of individual vitamin K dependent coagulation factors in healthy individuals without anticoagulation treatment. Methods Forty healthy volunteers between 25 and 40 years old were recruited. They received 90 μg of vitamin K2 every day for 30 days. Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalized ratio (INR), fibrinogen (FIB) levels and blood coagulation factors II, VII, IX, and X activity levels (F II : C, FⅦ : C, FⅨ : C,FⅩ : C), protein induced by vitamin K absence or antagonist-II (PIVKA-II), which is uncarboxylated prothrombin were measured at day 0, and day 30 after vitamin K2 administration. Plasma diluted 1:10 from vitamin K2 group and healthy control group were assayed for the activity of factors II, VII, IX, and X. Results PT, APTT, TT, and FIB did not show significant difference at day 30 when compared with baseline. The activities of coagulation factors II, VII, IX, and X was not significantly different with baseline (97.28 ± 12.42% vs. 99.96 ± 10.24%, P = 0.24 for F II: C; 76.12 ± 15.82% vs. 76.40 ± 12.33%, P = 0.92 for FⅦ: C; 97.65 ± 13.98% vs. 99.65 ± 13.30%, P = 0.47 for FⅨ: C; 89.18 ± 10.76% vs. 92.01 ± 10.46%, P = 0.1 for FⅩ: C) . PIVKA-II levels were not changed with 30 days vitamin K2 supplementation (21.62 ± 3.21 vs. 23.87 ± 2.65 mAU/ml, P = 0.16). After 30 days vitamin K2 administration, factor II, Ⅶ, Ⅸ, and Ⅹ activity of plasma diluted up to 10 times were proportionally decreased, and did not show significant difference with the healthy control without vitamin K2 exposure (10.32 ± 1.24% vs. 10.97 ± 1.55%, P = 0.38 for F II: C; 9.52 ± 2.94% vs. 9.14 ± 1.79%, P = 0.68 for FⅦ: C; 11.78 ± 2.12% vs.11.65 ± 1.54%, P = 0.87 for FⅨ: C; 8.22 ± 1.28% vs. 8.92 ± 1.13%, P = 0.21 for FⅩ: C). Conclusions Vitamin K2 supplementation at recommended dosage does not affect vitamin K-dependent coagulation factors activity in healthy subjects. Uncarboxylated prothrombin (PIVKA-II) in healthy individuals is not decreased with vitamin K supplementation. Funding Sources None.

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Increased Mean Platelet Volume in Patients With Aortic Stenosis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029610379400 ◽

2010 ◽

Vol 17 (6) ◽

pp. E17-E20 ◽

Cited By ~ 12

Author(s):

Ercan Varol ◽

Akif Arslan ◽

Habil Yucel ◽

Mehmet Ozaydin ◽

Dogan Erdogan ◽

...

Keyword(s):

Aortic Stenosis ◽

Platelet Activation ◽

Mean Platelet Volume ◽

Matched Control ◽

Control Group ◽

Study Group ◽

Platelet Volume ◽

Echocardiographic Examination ◽

The Mean ◽

And Control

Background: Systemic thromboembolism is a serious complication in patients with aortic stenosis (AS). Previous studies have demonstrated that platelet activation occurs in patients with AS. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with AS. Patients and Methods: The study group consisted of 43 patients with AS. An age-, gender-, and body mass index−matched control group consisted of 35 healthy volunteers. All patients and control participants underwent echocardiographic examination. We measured the serum MPV values in patients and control participants. Results: Mean platelet volume was significantly higher among patients with AS when compared with the control group (8.7 ± 1.0 vs 7.9 ± 0.9 fL, respectively; P = .001). Conclusion: We have shown that MPV was significantly elevated in patients with AS compared to control participant.

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Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP)

Mediators of Inflammation ◽

10.1155/2016/9894716 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 10

Author(s):

Baris Alper ◽

Baris Erdogan ◽

Mehmet Özgür Erdogan ◽

Korkut Bozan ◽

Murat Can

Keyword(s):

Mean Platelet Volume ◽

Injury Severity ◽

Serum Levels ◽

Study Group ◽

Platelet Volume ◽

Trauma Severity ◽

Severity Scores ◽

Severity Of Injury ◽

Significant Difference ◽

The Mean

We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1βand IL6), and the serum levels of tumour necrosis factor-α(TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (allpvalues < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p> 0.05). The TNFαand IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1βlevel was higher in the study group but did not increase as the ISS increased. IL6 and TNFαlevels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFαlevels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1βlevel is useful for this purpose.

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Evaluation of Cervical Dysfunctions in Temporomandibular Disorders

Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy ◽

10.5222/bmj.2021.92485 ◽

2021 ◽

Author(s):

Mustafa Çorum

Keyword(s):

Neck Pain ◽

Temporomandibular Disorders ◽

Healthy Subjects ◽

Healthy Control Group ◽

Control Group ◽

Pain Group ◽

Pain Provocation ◽

Significant Difference ◽

Upper Cervical ◽

Healthy Control

Objective: The purpose of this study is to investigate upper cervical segmental dysfunctions in female patients with chronic TMD with and without neck pain and to compare them with healthy subjects. Method: Patients admitted to our hospital with jaw pain were evaluated in this study, and a total of 152 patients and healthy subjects who met the inclusion criteria for the study were divided into 3 groups: TMD with neck pain (n = 94), TMD without neck pain (n = 28) and control (n = 30). Patients with myofascial pain (category I) or disc displacements (category II) were diagnosed based on the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) guidelines. Upper cervical segmental dysfunctions were identified using functional and pain provocation tests in patients with TMD and healthy subjects. Results: When patients with TMD were classified, there was a significant difference between TMD with neck pain (category I, 62.8%; category II, 37.2%) and TMD without neck pain (category I, 28.6%; category II, 71.4%) groups (p = 0.002). There was a statistically significant dysfunction [difference] in all upper cervical segments in favor of the TMD with neck pain group compared TMD without neck pain group and healthy control group (p < 0.05). 51.1% Occiput-C1, 81.9% C1-C2 and 53.2% C2-C3 segment dysfunction rates were detected in TMD with neck pain group. Conclusion: Upper cervical segmental dysfunction rate was higher in TMD group with neck pain than TMD without neck pain and healthy control group.

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The Role of Mean Platelet Volume on Distinction of Submucosal Myomas from Other Etiologies in Increased Endometrial Thickness

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.108 ◽

2016 ◽

Vol 22 (1) ◽

Author(s):

Kerem Doğa Seçkin ◽

Mehmet Fatih Karslı ◽

Burak Yücel ◽

Elif Akkaş Yılmaz ◽

Murat Öz ◽

...

Keyword(s):

Mean Platelet Volume ◽

Blood Count ◽

Complete Blood Count ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Reproductive Age ◽

White Blood Count ◽

Control Group ◽

Platelet Volume ◽

Significant Difference

OBJECTIVE: The aim of the study was to determine whether it is possible to differentiate submucosal fibroids before interventional procedures based on mean platelet volume (MPV), in reproductive-age patients presenting with endometrial thickening and abnormal uterine bleeding. STUDY DESIGN: This study included 581 reproductive-age women who underwent diagnostic procedures (curettage or operative hysteroscopy) and were subsequently divided into two groups based on clinico-pathological findings. The first group included those with benign endometrial pathology (control group, n=438), and the second group consisted of those with submucosal leiomyomas (n=143). The demographic characteristics and complete blood count (CBC) data of these patients were collected retrospectively, and comparisons were made between groups. RESULTS: No statistically significant difference was found between the groups according to demographic features and CBC parameters such as hemoglobin levels and white blood count (p>0,05). Platelet counts were significantly higher and MPV values were significantly lower in submucosal leiomyoma patients compared with the control subjects (p<0,05). CONCLUSIONS: MPV may be a useful predictive marker when differentiating submucosal leiomyoma from other benign causes of abnormal uterine bleeding. The ability to predict the possibility of the presence of submucosal leiomyoma before surgery can assist in determining the most appropriate type of invasive procedure.

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Role of Mean Platelet Volume in Diagnosis of Childhood Acute Appendicitis

Emergency Medicine International ◽

10.1155/2012/823095 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 14

Author(s):

Bunyamin Uyanik ◽

Cemil Kavalci ◽

Engin Deniz Arslan ◽

Fevzi Yilmaz ◽

Ozgur Aslan ◽

...

Keyword(s):

Acute Appendicitis ◽

Mean Platelet Volume ◽

Diagnostic Value ◽

Control Group ◽

Healthy Children ◽

Platelet Volume ◽

Pediatric Age Group ◽

Significant Difference ◽

Group 2 ◽

Group 1

Introduction. Acute appendicitis is the leading cause of abdominal pain in children requiring emergency surgical intervention. The aim of this study is to investigate the diagnostic value of MPV in early diagnosis of acute appendicitis cases in pediatric age group.Methods. This study was performed retrospectively. Three hundred five patients operated on with the diagnosis of appendicitis and pathologically found to be acute appendicitis were classified as Group 1 and 305 healthy children were classified as control Group 2.Results. One hundred ninety-seven of 305 cases in Group 1 are males (64.6%), in Group 2, 151 of 305 cases are males (49.5%). The mean MPV in Group 1 was7.9±0.9(fL), and whereas in Group 2 was7.7±0.8(fL). There was no statistically significant difference regarding MPV values (P>0.05).Conclusion. In our study we detected that mean platelet volume has no diagnostic value in pediatric acute appendicitis cases.

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Taste Sensitivity to Phenylthiourea Among Leprosy and Filarial Patients in Coastal Andhra Pradesh

Acta geneticae medicae et gemellologiae ◽

10.1017/s0001566000010680 ◽

1972 ◽

Vol 21 (4) ◽

pp. 332-336

Author(s):

B.R. Busi

Keyword(s):

Healthy Subjects ◽

Andhra Pradesh ◽

Healthy Control Group ◽

Taste Sensitivity ◽

Control Group ◽

Normal Individuals ◽

Significant Difference ◽

Leprosy Patients ◽

Healthy Control

SummaryTaste blindness for PTC has been studied in (a) 416 leprosy patients and 424 healthy subjects, and (b) 261 filarial patients and 136 normal individuals of both sexes. A significant difference was found between leprosy patients and the healthy control group in the proportion of nontasters (χ2 = 4.096, for 1 DF, P〈0.05). No significant difference could be observed between the filariasis and the control group (χ2 = 0.605, for 1 DF, P〉0.30).

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Effect of designed nursing guidelines on acute anal fissure treatment outcomes

Journal of Nursing Education and Practice ◽

10.5430/jnep.v8n10p1 ◽

2018 ◽

Vol 8 (10) ◽

pp. 1

Author(s):

Esmat Sayed Abd-Elmaged ◽

Amna Abdallh Desoky ◽

Tarik Abd-Elazem Abd-Elrahem

Keyword(s):

Wound Healing ◽

Anal Fissure ◽

General Surgery ◽

Rating Scale ◽

University Hospital ◽

Control Group ◽

Study Group ◽

Pain Level ◽

Significant Difference ◽

Nursing Guidelines

Objective: Anal fissure is a common problem through the world, it causes considerable morbidity. The aim of the study was to evaluate the effect of designed nursing guidelines on acute anal fissure treatment outcomes.Methods: Research design: Quasi-experimental design. Setting: General Surgery Wards and Outpatient Clinics of General Surgery at Assiut University Hospital. Sample: A purposive sample of 60 male and female adult patients diagnosed of having acute anal fissure. Patients were equally divided on random basis into two equal groups (study and control) 30 patients for each. Tools: Tool I-Patient assessment sheet. Tool II-Numeric Pain Rating Scale. Tool III-Bates-Jensen Wound Assessment Tool.Results: No statistically significant difference was found between the study and the control groups as regard demographic data. There was a statistically significant improvement in the pain level and wound healing among the study group (1.63 ± 2.08 and 11.93 ± 4.5 respectively) than in the control group (2.87 ± 2.33 and 14.43 ± 4.29 respectively). Also, there was a high statistically significant improvement in the level of knowledge of the study group than their level before applying the guidelines (p < .001).Conclusions: Designed nursing guidelines had a statistically significant effect on improving patients' knowledge, pain level, and wound healing among the study group patients than among the control group ones with acute anal fissure. Recommendations: Patients teaching should be an integral part of the nurses' duty in all hospitals. Further studies on larger sample from different geographical areas in Egypt to generalize the results.

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Comparison of Mean Platelet Volume in Acute Myocardial Infarction vs. Normal Coronary Angiography

Global Journal of Health Science ◽

10.5539/gjhs.v8n11p320 ◽

2016 ◽

Vol 8 (11) ◽

pp. 320 ◽

Cited By ~ 2

Author(s):

Alireza Rai ◽

Mohammadreza Saidi ◽

Nahid Salehi ◽

Farzad Sahebjamei ◽

Masoud Jalilian ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Platelet Count ◽

Coronary Angiography ◽

University Hospital ◽

Control Group ◽

Platelet Volume ◽

St Segment Elevation ◽

Significant Difference ◽

Normal Coronary Angiography

Considering the importance of cardiovascular disease and the role that platelets have in thrombosis formation in the coronary arteries, this study was done in order to assess platelet-related indices in patients who suffered acute myocardial infarction (MI) and compare them with those who had normal coronary angiography results.In this descriptive-analytical study, 200 patients who were admitted to our university hospital due to chest pain were included. The patients were divided into five groups including ST-segment elevation MI (STEMI), non-STEMI, unstable angina (UA), stable angina (SA), and healthy subjects (as control group). Platelet-related indices including platelet count as well asmean platelet volume (MPV) was determined. For this purpose, blood samples were taken from the patients upon admission and platelet count and volume were measured within three hours of admission.There was no statistically significant difference regarding MPV between the study groups (P> 0.05).MPV did not have any role in diagnosing various types of coronary artery disease (CAD).

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