Binding of Streptococcus mutans to extracellular matrix molecules and fibrinogen

2002 ◽  
Vol 298 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Anjum M Beg ◽  
Micheala N Jones ◽  
Tracey Miller-Torbert ◽  
Robert G Holt
Keyword(s):  
Extracellular Matrix ◽  
Streptococcus Mutans ◽  
Extracellular Matrix Molecules

scholarly journals Evolving Up‐regulation of Biliary Fibrosis–Related Extracellular Matrix Molecules After Successful Portoenterostomy

2021 ◽  
Author(s):  
Antti Kyrönlahti ◽  
Nimish Godbole ◽  
Oyediran Akinrinade ◽  
Tea Soini ◽  
Iiris Nyholm ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Molecules

scholarly journals Analogs of Eap Protein Are Conserved and Prevalent in Clinical Staphylococcus aureus Isolates

2001 ◽  
Vol 8 (6) ◽  
pp. 1271-1276 ◽  
Author(s):  
Muzaffar Hussain ◽  
Karsten Becker ◽  
Christof von Eiff ◽  
Georg Peters ◽  
Mathias Herrmann
Keyword(s):  
Staphylococcus Aureus ◽  
Extracellular Matrix ◽  
Staphylococcus Epidermidis ◽  
Translation Termination ◽  
Pcr Analysis ◽  
Cloning And Sequencing ◽  
Extracellular Matrix Molecules ◽  
Size Variability ◽  
Early Translation ◽  
High Degree

ABSTRACT Map and Eap are secreted Staphylococcus aureus proteins that interact with various extracellular matrix molecules. PCR analysis using map primers yielded positive reactions in 97.9% of S. aureus isolates but not in Staphylococcus epidermidis isolates. Cloning and sequencing of the conferring genes revealed a high degree of overall homology combined with size variability of the gene product due to various repeat numbers and early translation termination in a poly(A) region. Thus, Map and Eap may provide a potential novel tool forS. aureus identification and typing.

scholarly journals Cleavage of Extracellular Matrix Molecules: a role for ADAM8 in tumour cell invasion

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Taheera Ferdous ◽  
Panagiota Golfi ◽  
Uwe Schlomann ◽  
Marc D Zack ◽  
Joerg W Bartsch
Keyword(s):  
Extracellular Matrix ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Extracellular Matrix Molecules ◽  
Tumour Cell Invasion

scholarly journals Transforming growth factor–β in tissue fibrosis

2020 ◽  
Vol 217 (3) ◽  
Author(s):  
Nikolaos G. Frangogiannis
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cell Types ◽  
Cellular Targets ◽  
Extracellular Matrix Molecules ◽  
Interacting Networks

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β–driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.

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