Postischemic myocardial recovery and oxidative stress status of vitamin C deficient rat hearts

Aim and objectives: Rheumatoid arthritis (RA) is a chronic autoimmune systemic disease characterized predominantly by synovial inflammation, leading to joint destruction. The study was undertaken to analyze the vitamin –D and oxidative stress status in Rheumatoid arthritis Materials and methods: The Study includes Patients diagnosed as RA by using RA factor within the age group of30 to 60 years and comprised of 20 age matched control group. To assess oxidative stress, serum Malonyldialdehyde (MDA) was by thiobarbituric acid method and antioxidant level was assessed by estimation of serum vitamin C by dinitrophenyl hydrazine method. And vitamin D total is estimated by chemiluminescent immunoassay. Results: There is a significant decreased level of vitamin -D in the RA patients (37.58±5.7ng/ml) as compared to healthy controls (58.5±5.6ngl/ml). There is a a significant increased levels of MDA in the RA patients (7.6±1.09) as compared to healthy controls (8.4±2.8). There is a significant decreased level of vitamin -c in the RA patients (0.6±0.3mg/dl) as compared to healthy controls (1.0±0.31mg/dl). Conclusion: Low levels of Vitamin D deficiency in RA patients is associated with inflammation which leads to Increased oxidative stress status , which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.

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Modulatory Role of Riboceine and Vitamin C Supplementation on Altered Oxidative Stress Status of Alloxan-induced Diabetic Wistar Rats

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/13.4/75 ◽

2020 ◽

Vol 13 (4) ◽

pp. 2130-2138

Author(s):

Akingbade Bamidele Thomas

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Wistar Rats ◽

Oxidative Stress Status ◽

Vitamin C Supplementation

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Modulation of Age-Related Biochemical Changes and Oxidative Stress by Vitamin C and Glutathione Supplementation in Old Rats

Annals of Nutrition and Metabolism ◽

10.1159/000065402 ◽

2002 ◽

Vol 46 (5) ◽

pp. 165-168 ◽

Cited By ~ 11

Author(s):

M.A. Amer

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Biochemical Changes ◽

Age Related ◽

Old Rats ◽

And Oxidative Stress

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Beneficial Effect of Aqueous Garlic Extract on Inflammation and Oxidative Stress Status in the Kidneys of Type 1 Diabetic Rats

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-016-0621-6 ◽

2016 ◽

Vol 32 (3) ◽

pp. 329-336 ◽

Cited By ~ 12

Author(s):

Abolfazl Nasiri ◽

Nasrin Ziamajidi ◽

Roghayeh Abbasalipourkabir ◽

Mohammad Taghi Goodarzi ◽

Massoud Saidijam ◽

...

Keyword(s):

Oxidative Stress ◽

Beneficial Effect ◽

Diabetic Rats ◽

Garlic Extract ◽

Oxidative Stress Status ◽

And Oxidative Stress

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Relationship between atherogenic index and oxidative stress among patients presented with coronary artery disease in a tertiary care hospital

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4560 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 2807-2813

Author(s):

Resmi C R ◽

Kedari G S R ◽

Deepa P K

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Vitamin C ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Enzymatic Antioxidants ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Lipid Parameters ◽

And Oxidative Stress

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.

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