Enhanced bax gene expression reduces cell growth and sensitizes human gastric cancer cells to chemotherapeutic agents

2000 ◽  
Vol 118 (4) ◽  
pp. A535
Author(s):  
Koga Komatsu ◽  
Jun-ichi Miyazaki ◽  
Susumu Suzuki ◽  
Michiro Otaka ◽  
Sumio Watanabe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Bax Gene

scholarly journals Cre-loxP-mediated bax gene activation reduces growth rate and increases sensitivity to chemotherapeutic agents in human gastric cancer cells

2000 ◽  
Vol 7 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Koga Komatsu ◽  
Susumu Suzuki ◽  
Tooru Shimosegawa ◽  
Jun-ichi Miyazaki ◽  
Takayoshi Toyota
Keyword(s):  
Gastric Cancer ◽  
Growth Rate ◽  
Cancer Cells ◽  
Gene Activation ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Bax Gene

scholarly journals Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells

FEBS Letters ◽  
1999 ◽  
Vol 455 (1-2) ◽  
pp. 135-139 ◽  
Author(s):  
Nobuhiko Takahashi ◽  
Toshikatsu Okumura ◽  
Wataru Motomura ◽  
Yoshinori Fujimoto ◽  
Isao Kawabata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

POT1 deficiency alters telomere length and telomere-associated gene expression in human gastric cancer cells

2010 ◽  
Vol 19 (5) ◽  
pp. 345-351 ◽  
Author(s):  
Xiaoyan Ning ◽  
Shiming Yang ◽  
Rongquan Wang ◽  
Rugang Zhang ◽  
Liping Guo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cancer Cells ◽  
Telomere Length ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Liang Sun ◽  
Yizhou Yao ◽  
Ting Lu ◽  
Zengfu Shang ◽  
Shenghua Zhan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cancer Cell Growth ◽  
Normal Tissues

DAB2IP (DOC2/DAB2 interactive protein) is downregulated in several cancer types, and its downregulation is involved in tumor cell proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to investigate the potential role of DAB2IP in the development and progression of gastric cancer. DAB2IP levels were analyzed in human gastric cancer and adjacent normal tissues by Western blots and immunohistochemistry. Potential roles of DAB2IP in regulating gastric cancer cell growth and metastasis were examined by genetic manipulation in vitro. The molecular signaling was determined to understand the mechanisms of observed DAB2IP effects. DAB2IP level is lower in gastric cancer tissues as compared to paired normal tissues. Knockdown of DAB2IP enhanced gastric cancer cell growth and metastasis in vitro and promoted EMT progress at both protein and mRNA levels. Silencing DAB2IP activated extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, and the enhanced proliferation and migration ability induced by DAB2IP knockdown were reduced after incubation with U0126 in SGC7901 gastric cancer cells. Inhibition of DAB2IP enhances gastric cancer cell growth and metastasis through targeting the ERK1/2 signaling, indicating that it may serve as a potential target for treatment of gastric cancer.

scholarly journals HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells

2011 ◽  
Vol 2 (6) ◽  
pp. 1291-1295 ◽  
Author(s):  
HUI-YAN MA ◽  
FANG ZHANG ◽  
JIE LI ◽  
MIN-LI MO ◽  
ZHAO CHEN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Hedgehog Signaling ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells
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