251 Screening Colonoscopy and the Risk of Death From Right and Left Colon Cancers

2016 ◽  
Vol 150 (4) ◽  
pp. S61
Author(s):  
Chyke A. Doubeni ◽  
Douglas Corley ◽  
Virginia P. Quinn ◽  
Christopher D. Jensen ◽  
Ann G. Zauber ◽  
...  
Keyword(s):  
Left Colon ◽  
Screening Colonoscopy ◽  
Risk Of Death ◽  
Colon Cancers

scholarly journals Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study

Gut ◽  
2016 ◽  
Vol 67 (2) ◽  
pp. 291-298 ◽  
Author(s):  
Chyke A Doubeni ◽  
Douglas A Corley ◽  
Virginia P Quinn ◽  
Christopher D Jensen ◽  
Ann G Zauber ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mortality Risk ◽  
Left Colon ◽  
Screening Colonoscopy ◽  
Cancer Death ◽  
Right Colon ◽  
Community Based ◽  
Risk Of Death ◽  
Colon Cancers ◽  
Rectal Cancers

ObjectiveScreening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers.DesignWe conducted a nested case–control study with incidence-density matching in screening-eligible Kaiser Permanente members. Patients who were 55–90 years old on their colorectal cancer death date during 2006–2012 were matched on diagnosis (reference) date to controls on age, sex, health plan enrolment duration and geographical region. We excluded patients at increased colorectal cancer risk, or with prior colorectal cancer diagnosis or colectomy. The association between screening colonoscopy receipt in the 10-year period before the reference date and colorectal cancer death risk was evaluated while accounting for other screening exposures.ResultsWe analysed 1747 patients who died from colorectal cancer and 3460 colorectal cancer-free controls. Compared with no endoscopic screening, receipt of a screening colonoscopy was associated with a 67% reduction in the risk of death from any colorectal cancer (adjusted OR (aOR)=0.33, 95% CI 0.21 to 0.52). By cancer location, screening colonoscopy was associated with a 65% reduction in risk of death for right-colon cancers (aOR=0.35, CI 0.18 to 0.65) and a 75% reduction for left-colon/rectal cancers (aOR=0.25, CI 0.12 to 0.53).ConclusionsScreening colonoscopy was associated with a substantial and comparably decreased mortality risk for both right-sided and left-sided cancers within a large community-based population.

Mortality by colon, lung, esophagus, prostate, cervix and breast cancers in Brazilian capitals, 2000 to 2015: a multilevel analysis

2019 ◽  
Author(s):  
NÁDIA CRISTINA PINHEIRO RODRIGUES ◽  
Gisele O’Dwyer ◽  
Mônica Kramer de Noronha Andrade ◽  
Denise Leite Maia Monteiro ◽  
Inês Reis Nascimento Reis ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Cancer Mortality ◽  
Fixed Effects ◽  
Mortality Rates ◽  
Lung Cancers ◽  
Esophageal Cancers ◽  
Risk Of Death ◽  
Colon Cancers ◽  
Significant Difference ◽  
Risk Of Cancer

Abstract Background. In Brazil, cancer is the second most common cause of death, and the most incident types of cancer are prostate, breast, lung, colon and rectum. This study aimed to analyze the role of period, geographic and socio demographic factors in cancer-related mortality by prostate, breast, cervix, colon, lung and esophagus cancer in Brazilians capitals from 2000 to 2015. Methods. Data from 2005-2015 cancer mortality and resident population were collected from Information Technology Department of the Brazilian Unified Health System (DATASUS), the Brazilian Institute of Geography and Statistics (IBGE) and the Brazilian Mortality Information (SIM). State capitals were the study’s analytic units. A multilevel Poisson model was used to estimate the adjusted risk of cancer mortality (prostate, breast, cervix, colon, lung and esophageal cancers). The adjusted models included the following variables as fixed effects: age, Gross Domestic Product, region, year squared and year of death. Results. A statistically significant difference was found between mortality rates by gender for colon, lung and esophageal cancers. The highest mortality rates were observed in the older age group, especially for prostate and lung cancers, which values were higher than 100 deaths per 100,000. Comparing with those aged 40-59 years, men older than 59 years showed 47 times higher mortality risk for prostate cancer, 8-9 times higher for lung or colon cancers and four times higher for esophageal cancer. Compared with those aged 40-59 years, women older than 59 years old showed 5-7 times higher mortality risk for esophageal, lung or colon cancers and 2-3 times higher for breast or cervix cancers. Conclusions. Colon cancer mortality rate increased from 2000 to 2015 for both genders, while breast and lung cancers mortality increased over the period only for women. In both genders, the highest mortality risk for lung and esophageal cancers was observed in Southern capitals. Northern capitals had a lower risk of death by prostate and breast cancer and a higher risk of death by cervix cancer.

Right vs Left Colon Cancers Have Comparable Survival: a Decade’s Experience

2019 ◽  
Vol 82 (2) ◽  
pp. 134-141
Author(s):  
Metin Keskin ◽  
Emre Sivrikoz ◽  
Gülçin Yeğen ◽  
Adem Bayraktar ◽  
Cemil Burak Kulle ◽  
...  
Keyword(s):  
Left Colon ◽  
Colon Cancers

scholarly journals Comparison of oncological results after curative resection in right and left colon cancers

2020 ◽  
Vol 2 (56) ◽  
pp. 41-55
Author(s):  
Eyüp Murat Yilmaz ◽  
Erkan Karacan ◽  
Buse Yıldız ◽  
Murat Demir ◽  
Ahmet Ender Demirkiran
Keyword(s):  
Curative Resection ◽  
Left Colon ◽  
Colon Cancers ◽  
Oncological Results

scholarly journals Early-onset colorectal cancer: more than one side to the story

2020 ◽  
Vol 9 (3) ◽  
pp. CRC28
Author(s):  
Nina N Sanford ◽  
Pooja Dharwadkar ◽  
Caitlin C Murphy
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Age Groups ◽  
Younger Adults ◽  
Risk Of Death ◽  
Colon Cancers ◽  
All Cause Mortality ◽  
Colon And Rectum ◽  
The Impact ◽  
Early Onset Colorectal Cancer

Aim: To determine the impact of tumor sidedness on all-cause mortality for early- (age 18–49 years) and older-onset (age ≥50 years) colorectal cancer (CRC). Materials & methods: We conducted a retrospective study of 650,382 patients diagnosed with CRC between 2000 and 2016. We examined the associations of age, tumor sidedness (right colon, left colon and rectum) and all-cause mortality. Results: For early-onset CRC (n = 66,186), mortality was highest in the youngest age group (18–29 years), driven by left-sided colon cancers (vs 50–59 years, hazard ratio: 1.18; 95% CI: 1.03–1.34). 5-year risk of death among 18–29-year-olds with left-sided colon cancer (0.42, 95% CI: 0.38, 0.46) was higher than all other age groups. Conclusion: Left-sided colon cancers are enriched in younger adults and may be disproportionately fatal.

scholarly journals Differences Between Right and Left Colon Cancers in Terms of Clinicopathological Features and Long-term Oncological Outcomes

2020 ◽  
Vol 30 (4) ◽  
pp. 253-260
Author(s):  
Serkan Zenger ◽  
Bülent Gürbüz ◽  
Uğur Can ◽  
Çağrı Bilgiç ◽  
Erman Sobutay ◽  
...  
Keyword(s):  
Left Colon ◽  
Clinicopathological Features ◽  
Oncological Outcomes ◽  
Colon Cancers

Rectal versus left-sided colon cancers: Clinicopathological differences observed in a pooled analysis of 4,182 patients enrolled to 8 clinical trials from the ARCAD database.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 675-675 ◽  
Author(s):  
Mohamed E. Salem ◽  
Jun Yin ◽  
Lindsay A. Renfro ◽  
Benjamin Adam Weinberg ◽  
Tim Maughan ◽  
...  
Keyword(s):  
Primary Tumor ◽  
Biological Therapy ◽  
Lung Metastases ◽  
Multivariable Analysis ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Risk Of Death ◽  
Molecular Features ◽  
Colon Cancers ◽  
Increased Risk

675 Background: Recent retrospective analysis of CALGB/SWOG 80405 showed that left-sided colon cancers (LCC) respond differently to biological therapy compared with right-sided tumors. However, differences between rectal cancers (RC) and LCC remain undefined. Herein, we report our exploration of differences between these two groups. Methods: Individual patient data from 4182 patients (pts) with metastatic colorectal cancers, enrolled onto 8 first-line randomized trials, were pooled. Only pts with tumor locations that were clearly defined as LCC (splenic flexure to sigmoid) or RC were included in this analysis. Differences in pt characteristics and disease factors according to LCC vs. RC were identified. The prognostic effect of primary tumor location on OS and PFS was quantified via multivariable Cox proportional hazards modeling stratified by treatment arm within each study and adjusting for age, sex, performance status, and prior surgery. Results: In total, 2,479 (59%) pts with LCC and 1,703 (41%) pts with RC were identified. Pts with RC, compared with LCC, were more likely to be male (68% vs. 62%, p < 0.001), have lung metastases (mets) (56% vs. 37%, p < 0.001), and have 2 or more metastatic sites (64% vs. 60%, p < 0.02), whereas pts with LCC were more likely to have liver mets (84% vs. 76%, p < 0.001). RC had a greater frequency of KRAS mutations (41% vs. 37%, p = 0.04) than LCC but there were no differences in the frequency of BRAF mutations (5% vs. 4%, p = 0.2). In multivariable analysis, no differences in OS or PFS were observed between pts with LCC vs. RC. While risk of death did not differ by primary tumor location, across all pts with LCC or RC, those with liver mets had a 17% increased risk of death compared to those with lung mets (HR = 1.17, p = 0.03) after adjusting for effects of other variables. Forthcoming prognostic analysis of LCC vs. RC within grouped backbone treatments (e.g., FOLFOX and FOLFIRI) is underway. Conclusions: Tumors arising in the rectum may carry clinical and molecular features that are distinct from LCC. Further investigations are warranted to determine whether RC should be treated with the same chemo backbone and biological therapy as LCC.

Racial disparities in clinico-pathological features and survival rates of early-onset colorectal cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15089-e15089
Author(s):  
Ana Acuna Villaorduna ◽  
Meghan Kaumaya ◽  
Sanjay Goel
Keyword(s):  
Colorectal Cancer ◽  
Multivariate Analysis ◽  
Early Onset ◽  
Survival Rates ◽  
Screening Colonoscopy ◽  
Pathological Features ◽  
Risk Of Death ◽  
Common Location ◽  
Increased Risk ◽  
Early Onset Colorectal Cancer

e15089 Background: Early-onset colorectal cancer (EO-CRC) incidence is increasing disproportionately among minorities compared to Non-Hispanic Whites (NHW). EO-CRC have aggressive features such as higher grade and advanced stages. The appropriate age to start screening colonoscopy (SC) in NHW and minorities remains controversial; varying between 45 and 50 years old. We aim to compare EO-CRC clinico-pathological characteristics and survival rates by race groups. Methods: Patients with colorectal adenocarcinoma (CRC) with available race and stage as per AJCC 6th edition were identified using the SEER registry (1973-2010). EO-CRC was defined as CRC before age 50 years. Clinico-pathological features, overall survival (OS) by Kaplan Meier curves and mortality predictors by multivariate analysis were evaluated by race groups. Results: 180 605 patients with CRC were identified; 10.2% had EO-CRC. Mean age of diagnosis was 42.7 years and EO-CRC frequency was higher in minorities (Hispanics (H):16.7%, Non-Hispanic Black (NHB):12.7% and Asian (A): 12.8%) compared to NHW (8.7%). EO-CRC in NHB was predominantly seen in females. The rectum was the most common location for all races. Two-thirds of tumors were located between the sigmoid and anal regions in all races except NHB that had higher frequencies of right-sided tumors. Compared to other races, NHB had worse OS at all stages and tumor locations. NHB was associated with 72% increased risk of death by multivariate analysis. Conclusions: Our data suggest that EO-CRC frequency, pathological features and OS differ by race group; hence SC guidelines should be tailored accordingly. SC would be considered early; especially in minorities. Complete colonoscopy should be considered for NHB given higher rates of right-sided tumors and worse OS; while sigmoidoscopy may be adequate for others up to age 50, given higher rates of tumors located in the sigmoid to anal region. [Table: see text]

Mo1116 The Distribution and Appearance of Colorectal Polyps in the Right and Left Colon in Koreans : Implications for Screening Colonoscopy

2013 ◽  
Vol 144 (5) ◽  
pp. S-582
Author(s):  
Hee Sun Kim ◽  
Su Jung Baik ◽  
Kyung Hee Kim ◽  
Cho Rong Oh ◽  
Sang In Lee
Keyword(s):  
Colorectal Polyps ◽  
Left Colon ◽  
Screening Colonoscopy ◽  
The Right

scholarly journals IS THERE A DIFFERENCE BETWEEN RIGHT- VERSUS LEFT-SIDED COLON CANCERS? DOES SIDE MAKE ANY DIFFERENCE IN LONG-TERM FOLLOW-UP?

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Leonardo Alfonso BUSTAMANTE-LOPEZ ◽  
Sergio Carlos NAHAS ◽  
Caio Sergio R. NAHAS ◽  
Rodrigo Ambar PINTO ◽  
Carlos Frederico S. MARQUES ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Survival Time ◽  
Right Colon ◽  
Risk Of Death ◽  
Colon Cancers ◽  
Right Colon Cancer ◽  
Long Term Follow Up ◽  
Disease Entities ◽  
Left Colon Cancer

ABSTRACT Background: Since 1990 it was proposed that distal and proximal location of colon cancer might follow different biological, epidemiology, pathology and prognosis, probably due to embryologic different development of the two segments of the colon, which may represent two separate disease entities. These differences might have consequences for the treatment of patients with colorectal cancer. Aim: To compare the characteristics between patients with right and left colon cancer, with severity and tumor characteristic that influence in the survival of these patients. Method: Were evaluated the outcomes of surgical treatment of patients with colon cancer with data collected retrospectively from prospectively collected database. Results: The tumor’s side did not influence survival time of patients with colon cancer (p=0.112) in the regression model. Only the diseases stage leads to influence on survival time; patients with right colon cancer have more advanced staging (III or IV) and present a risk of death greater in 3.23 times. Conclusion: This analysis provides evidence that the prognosis of localized left-sided colon cancer is better compared to right-sided colon cancer. Also, the patients with right colon cancer have more advanced stage, mucinous tumor and are older.

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