M.581 The LEU554PHE polymorphism in the E-selectin gene is associated with blood pressure in overweight people

P117 A recent report by Tiret et al. (Hypertension 33, 1999) revealed that a G/T polymorphism with an amino acid substitution (Lys to Asn) at codon 198 in the exon 5 of endothelin 1 gene (ET1) is associated with blood pressure in overweight people using two epidemiological studies, ECTIM and Glasgow Heart Scan Study. They suggested that G/T polymorphism strongly interacted with body mass index (BMI) in the determination of blood pressure levels. To examine the interaction among G/T polymorphism of ET1, BMI and blood pressure, we carried out an association study using a general population. Subjects (n=1,446) were recruited from Ohasama population, which is a cohort in a rural community of northern Japan. The research protocol was approved by the Institutional Review Board of the Tohoku University. DNA was extracted from the buffy coat of the participants using QIAamp DNA Blood Kit (Qiagen Inc.). G/T polymorphism of ET1 was determined by TaqMan PCR method, which is a powerful tool for semiautomatic genotype determination in a large number of samples. The frequency of T198 allele in Japanese (26%) was significantly higher than that in Caucasians (23%). The baseline characteristic (age, BMI, SBP, DBP, antihypertensive treatment) of all subjects was not significantly different according to the genotype of G/T polymorphism. In the obese subjects (≥25kg/m2), however, SBP and DBP were significantly associated with G/T polymorphism. Blood pressure level in the subjects carrying T198 allele was 2.6 mmHg in systolic (p<0.02) and 2.3 mmHg in diastolic (p<0.005) higher than that in those with GG genotype in overweight people. That the same result was obtained from different races suggested that the T198 allele of ET1 is involved in the determination of blood pressure levels in obese subjects.

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M.581 The LEU554PHE polymorphism in the E-selectin gene is associated with blood pressure in overweight people

Atherosclerosis Supplements ◽

10.1016/s1567-5688(04)90579-5 ◽

2004 ◽

Vol 5 (1) ◽

pp. 135

Author(s):

J. Marteau ◽

C. Sass ◽

M. Pfister ◽

D. Lambert ◽

M. Noyer-Weidner ◽

...

Keyword(s):

Blood Pressure ◽

Overweight People

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The Lys198Asn Polymorphism in the Endothelin-1 Gene Is Associated With Blood Pressure in Overweight People

Hypertension ◽

10.1161/01.hyp.33.5.1169 ◽

1999 ◽

Vol 33 (5) ◽

pp. 1169-1174 ◽

Cited By ~ 126

Author(s):

Laurence Tiret ◽

Odette Poirier ◽

Vincent Hallet ◽

Theresa A. McDonagh ◽

Caroline Morrison ◽

...

Keyword(s):

Blood Pressure ◽

Endothelin 1 ◽

Overweight People

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Blood Pressure and its Association with Body Mass Index Among the People Attending in a Hospital

Journal of Nepal Medical Association ◽

10.31729/jnma.3433 ◽

2017 ◽

Vol 56 (208) ◽

pp. 451-5 ◽

Cited By ~ 1

Author(s):

Dinesh Kumar Lamsal

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Diastolic Blood Pressure ◽

Body Mass ◽

Civil Service ◽

Overweight And Obesity ◽

Age Group ◽

Overweight People ◽

Diastolic Hypertension ◽

Significant Difference

Introduction: Systolic and diastolic hypertension has been increasing trend and different factors are associated such as body mass index, diabetes etc. Obesity and overweight are generally associated with high blood pressure. This study aims to identify the prevalence of blood pressure level and its association to body mass index among people attending in civil service hospital, Kathmandu. Methods: A cross-sectional descriptive study was conducted among all 1002 study subjects aged above 20 years.Information were obtained from people coming for Master health check-up during study period. Blood pressure and weight weretaken by WHO certified tool. Results: Half of the respondents were overweight and obese. Prevalence of systolic and diastolic hypertension was found to be 171 (17.1%) and 310 (30.9%) respectively. There is significant difference between body mass index to sex. Females are 1.5 times more likely to have high blood pressurewho have high body mass index. Age group (40-59) years are more than two times likely to have overweight, systolic and diastolic blood pressure than other age group. Systolic blood pressure is more than six times more likely to be high in 60+ age group. But it is only 2.6 times in diastolic blood pressure and in body mass index, it is reduced to 1.4 times but it was still statistically significant. Overweight people are 1.4 and 1.6 times more likely to have high systolic and diastolic BP than another category. Conclusions: Half of the respondents were overweight and obese. Male had high overweight and obesity than female. Overweight people more likely to have high systolic and diastolic BP than others. Keywords: Body mass index; blood pressure; civil service hospital; Nepal.

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Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. The Trials of Hypertension Prevention Collaborative Research Group

Archives of Internal Medicine ◽

10.1001/archinte.157.6.657 ◽

1997 ◽

Vol 157 (6) ◽

pp. 657-667 ◽

Cited By ~ 107

Keyword(s):

Blood Pressure ◽

Weight Loss ◽

Phase Ii ◽

Research Group ◽

Collaborative Research ◽

Normal Blood ◽

Sodium Reduction ◽

Normal Blood Pressure ◽

Overweight People ◽

Hypertension Prevention

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Patterns of Raised Blood Pressure in Vietnam: Findings from the WHO STEPS Survey 2015

International Journal of Hypertension ◽

10.1155/2019/1219783 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Van Minh Hoang ◽

Quoc Bao Tran ◽

Thi Hoang Lan Vu ◽

Thi Kim Ngan Nguyen ◽

Bao Giang Kim ◽

...

Keyword(s):

Blood Pressure ◽

Ethnic Minority ◽

Minority Groups ◽

Adult Population ◽

Overweight People ◽

Diabetes Status ◽

Blood Pressure Data ◽

Steps Survey ◽

Nationally Representative ◽

And Control

This study aims to describe the prevalence of raised blood pressure and the situation of management for raised blood pressure among the adult population in Vietnam. It also aims to examine the association between diversified socioeconomic and behavioral factors of raised blood pressure and awareness of raised blood pressure. Data were obtained from the STEPS survey conducted in Vietnam in 2015. Survey sample was nationally representative with a total of 3,856 people aged 18–69 years old. The study outcomes included raised blood pressure and awareness of and control of raised blood pressure. Multiple logistic regression was used to examine the association of socioeconomic and behavior risk factors with the outcome variables. The overall prevalence of raised blood pressure in Vietnam in 2015 was 18.9% (95% CI: 17.4%–20.6%). The prevalence of raised blood pressure was higher among men. Significantly correlated factors with raised blood pressure were age, sex, body mass index, and diabetes status. Levels of awareness of raised blood pressure were higher among the older age group and overweight people and lower among ethnic minority groups. Raised blood pressure in Vietnam is a serious problem due to its magnitude and the unacceptably high unawareness rate in the population. Public health actions dealing with the problems of raised blood pressure are urgent, while taking into account its relationship with sex and socioeconomic status. It is clear that the interventions should address all people in society, with a focus on disadvantaged groups which are the rural and ethnic minority peoples.

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