Positive Association Between the Lys198 Asn Polymorphism in the Endothelin-1 and Blood Pressure in Obese Japanese Subjects: Ohasama Study

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 714-714
Author(s):  
Tomohiro Katsuya ◽  
Takayoshi Ohkubo ◽  
Yuxiao Fu ◽  
Ichiro Tsuji ◽  
Kenichi Nagai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Level ◽  
Positive Association ◽  
Epidemiological Studies ◽  
Buffy Coat ◽  
Baseline Characteristic ◽  
Endothelin 1 ◽  
Overweight People ◽  
Obese Subjects

P117 A recent report by Tiret et al. (Hypertension 33, 1999) revealed that a G/T polymorphism with an amino acid substitution (Lys to Asn) at codon 198 in the exon 5 of endothelin 1 gene (ET1) is associated with blood pressure in overweight people using two epidemiological studies, ECTIM and Glasgow Heart Scan Study. They suggested that G/T polymorphism strongly interacted with body mass index (BMI) in the determination of blood pressure levels. To examine the interaction among G/T polymorphism of ET1, BMI and blood pressure, we carried out an association study using a general population. Subjects (n=1,446) were recruited from Ohasama population, which is a cohort in a rural community of northern Japan. The research protocol was approved by the Institutional Review Board of the Tohoku University. DNA was extracted from the buffy coat of the participants using QIAamp DNA Blood Kit (Qiagen Inc.). G/T polymorphism of ET1 was determined by TaqMan PCR method, which is a powerful tool for semiautomatic genotype determination in a large number of samples. The frequency of T198 allele in Japanese (26%) was significantly higher than that in Caucasians (23%). The baseline characteristic (age, BMI, SBP, DBP, antihypertensive treatment) of all subjects was not significantly different according to the genotype of G/T polymorphism. In the obese subjects (≥25kg/m2), however, SBP and DBP were significantly associated with G/T polymorphism. Blood pressure level in the subjects carrying T198 allele was 2.6 mmHg in systolic (p<0.02) and 2.3 mmHg in diastolic (p<0.005) higher than that in those with GG genotype in overweight people. That the same result was obtained from different races suggested that the T198 allele of ET1 is involved in the determination of blood pressure levels in obese subjects.

scholarly journals The Lys198Asn Polymorphism in the Endothelin-1 Gene Is Associated With Blood Pressure in Overweight People

Hypertension ◽  
1999 ◽  
Vol 33 (5) ◽  
pp. 1169-1174 ◽  
Author(s):  
Laurence Tiret ◽  
Odette Poirier ◽  
Vincent Hallet ◽  
Theresa A. McDonagh ◽  
Caroline Morrison ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelin 1 ◽  
Overweight People

scholarly journals Association between Greenspace and Blood Pressure: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Yu Zhao ◽  
◽  
WenWen Bao ◽  
BoYi Yang ◽  
JingHong Liang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Positive Association ◽  
Epidemiological Studies ◽  
Review Question ◽  
Possible Cause

Review question / Objective: Hypertension is a major risk factor for cardiovascular disease, which remains the leading cause of mortality worldwide. Urban environment as an possible cause of hypertension has received great attention. We aimed to systematically review the associations between greenspace and blood pressure (BP) levels/hypertension and use a meta-analysis to quantify the effects of greenspace on BP levels/hypertension. Condition being studied: Many epidemiological studies have assessed associations of greenspace with blood pressure levels and/or the prevalence of hypertension, whereas the results was inconsistent with some studies showing positive association but the others reporting null or negative associations. Systematic review and meta-analysis was conducted to synthesize data quantitatively across studies based on the primary outcome.

scholarly journals Hypertension and insomnia

2020 ◽  
Vol 92 (1) ◽  
pp. 69-75
Author(s):  
T M Ostroumova ◽  
V A Parfenov ◽  
O D Ostroumova ◽  
A I Kochetkov
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Cognitive Functions ◽  
Blood Pressure Monitoring ◽  
Blood Pressure Level ◽  
Pressure Profile ◽  
Epidemiological Studies ◽  
Blood Pressure Profile ◽  
The Relationship ◽  
Frequent Presence

Insomnia is frequently detected in patients with arterial hypertension (AH): from 19% to 47.9% of all cases according to epidemiological studies. On the other hand, the frequency of hypertension in patients with insomnia ranges from 21.4% to 50.2%, whereas in patients without insomnia, from 11.0% to 41.8%. In single studies in which patients with insomnia underwent ambulatory blood pressure monitoring (ABPM), these patients showed higher nocturnal blood pressure levels. Recent data suggests that insomnia is also a risk factor for hypertension. Among the pathogenetic mechanisms explaining the relationship between hypertension and insomnia, an increase in the activity of the main neuroendocrine stress systems, sympatho - adrenal and hypothalamic - pituitary - adrenal, and the frequent presence of concomitant anxiety disorders are discussed. To determine the sleep quality in patients with insomnia, the Pittsburgh Sleep Quality Index (PSQI) is most often used, patients with hypertension in a number of studies had higher total PSQI score compared to individuals with normal blood pressure. PSQI score correlates with systolic and diastolic blood pressure level, as well as with the presence of non - dipper blood pressure profile. Both hypertension and insomnia are associated with impaired cognitive functions. However, the relationship between cognitive impairment and insomnia is rather contradictory, which is most associated with the methodology for assessing cognitive functions and differences in the initial clinical and demographic characteristics of the examined patient population.

OPTIMIZATION OF ARTERIAL HYPERTENSION TREATMENT IN DIABETIC PATIENTS

2020 ◽  
pp. 37-41
Author(s):  
Андрей Петрович Бабкин
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Therapy ◽  
Blood Pressure Level ◽  
Load Test ◽  
Diabetic Patients ◽  
Table Salt ◽  
Patients With Diabetes ◽  
Baseline Values ◽  
The Individual

Достижение целевого уровня артериального давления у больных сахарным диабетом является такой же важной задачей, как и коррекция метаболических нарушений. Проведен анализ эффективности комбинированной антигипертензивной терапии у больных сахарным диабетом с диабетической нефропатией на основе динамики гемодинамических и метаболических параметров у больных с различной реакцией артериального давления на нагрузку поваренной солью. Выяснено, что больные с данной патологией не одинаково реагируют на нагрузку поваренной солью - у 23 (53,3 %) пациентов выявлено повышение систолического АД на 10 и более мм рт. ст. (солечувствительные пациенты), а у 21 (46,7%) повышение АД было менее 10 мм рт. ст. или отсутствовало (солерезистентные пациенты). Солечувствительные пациенты имели более высокие исходные значения показателей суточного мониторирования АД - САД ср. у солечувствительных пациентов равнялось 157,4 ± 1,0 мм рт. ст. против 150,7 ± 0,8 мм рт. ст. у солерезистентных пациентов, р<0,01. Обе комбинации лекарственных препаратов показали сопоставимый антигипертензивный эффект. Установлено, что у больных, принимавших комбинацию периндоприла и индапамида и вальсартана и индапамида, более выраженный антигипертензивный эффект был отмечен у больных с солечувствительным характером артериальной гипертонии в каждой группе лечения. Определение солечувствительности АД позволяет прогнозировать индивидуальную эффективность антигипертензивной терапии на основе использования теста с нагрузкой поваренной солью Reaching the target blood pressure level in diabetic patients is as important as correcting metabolic disorders. The analysis of the effectiveness of combined antihypertensive therapy in patients with diabetes mellitus with diabetic nephropathy based on the dynamics of hemodynamic and metabolic parameters in patients with different reactions of blood pressure to the load of table salt. It was found that patients with this pathology do not equally respond to the load of table salt - 23 (53.3%) patients showed an increase in systolic blood pressure by 10 mm Hg or more. Art. (salt-sensitive patients), and in 21 (46.7%) the increase in blood pressure was less than 10 mm Hg. Art. or absent (salt-resistant patients. Salt-sensitive patients had higher baseline values of 24-hour BP monitoring - SBP mean in salt-sensitive patients was 157.4 ± 1.0 mm Hg versus 150.7 ± 0.8 mm Hg in salt-resistant patients, p <0.01. Both drug combinations showed a comparable antihypertensive effect. Determination of blood pressure salt sensitivity makes it possible to predict the individual effectiveness of antihypertensive therapy based on the use of a salt load test

scholarly journals Discriminating Bangladeshi Adults by Level of Blood Pressure

2020 ◽  
Vol 1 (1) ◽  
pp. 6-16
Author(s):  
KC Bhuyan ◽  
Keyword(s):  
Blood Pressure ◽  
Rural Areas ◽  
Blood Pressure Level ◽  
Income Group ◽  
Lower Income ◽  
Lower Income Group ◽  
Obese Subjects ◽  
Urban And Rural Areas ◽  
Optimal Blood Pressure ◽  
Sedentary Activities

The objective of the present work was to discriminate Bangladeshi adults of 18 years and above according to their blood pressure level and to identify some factors responsible for discrimination. Accordingly, the analysis was done utilizing the data collected from 960 adults of both urban and rural areas. The respondents were investigated by some doctors and nurses from and nearby their working places. During investigation, the blood pressure (mmHg) of the respondents were recorded. It was observed that 45.4% adults had optimal blood pressure. The percentages of normal, high normal and hypertensive adults were 39.5, 9.4 and 5.7, respectively. High normal and hypertension was more likely among urban, non-Muslim, female, single, aged, illiterate, physically inactive, involved in sedentary activities, obese subjects. Adults of lower income group of families and higher expenditure group of families were also more exposed to the problem of higher blood pressure. The problem was more likely in smokers, restaurant and can food consumers. Age, utilization of time, and accustomed with can food were the most responsible factors in discriminating the adults of different groups. The other responsible variables were gender variation, level of education and body mass index (BMI).

Weight reduction regresses left ventricular mass regardless of blood pressure level in obese subjects

1996 ◽  
Vol 131 (2) ◽  
pp. 313-319 ◽  
Author(s):  
Etsuro Himeno ◽  
Kenji Nishino ◽  
Yoshiyuki Nakashima ◽  
Akio Kuroiwa ◽  
Masaharu Ikeda
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Weight Reduction ◽  
Blood Pressure Level ◽  
Left Ventricular ◽  
Pressure Level ◽  
Ventricular Mass ◽  
Obese Subjects
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