3.P.261 Identification of cell types expressing platelet derived growth factor B chain and β receptor in human atherosclerotic plaques: Immunocytochemical study with double and triple staining techniques

1997 ◽  
Vol 134 (1-2) ◽  
pp. 253
Author(s):  
Shin-ichi Tanizawa ◽  
Makiko Ueda ◽  
Ryushi Komatsu ◽  
Takahiko Naruko ◽  
Anton E. Becker
Keyword(s):  
Growth Factor ◽  
Cell Types ◽  
Platelet Derived Growth Factor ◽  
Atherosclerotic Plaques ◽  
Immunocytochemical Study ◽  
Factor B ◽  
Staining Techniques ◽  
Β Receptor ◽  
Triple Staining

scholarly journals Expression and function of PDGF-C in development and stem cells

Open Biology ◽  
2021 ◽  
Vol 11 (12) ◽  
Author(s):  
Yi Tian ◽  
Ying Zhan ◽  
Qin Jiang ◽  
Weisi Lu ◽  
Xuri Li
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Progenitor Cell ◽  
Cell Types ◽  
Platelet Derived Growth Factor ◽  
Tissue Remodelling ◽  
Factor B ◽  
The Past ◽  
Factor C ◽  
And Function

Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family, discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and platelet-derived growth factor B (PDGF-B). PDGF-C is generally expressed in most organs and cell types. Studies from the past 20 years have demonstrated critical roles of PDGF-C in numerous biological, physiological and pathological processes, such as development, angiogenesis, tumour growth, tissue remodelling, wound healing, atherosclerosis, fibrosis, stem/progenitor cell regulation and metabolism. Understanding PDGF-C expression and activities thus will be of great importance to various research disciplines. In this review, however, we mainly discuss the expression and functions of PDGF-C and its receptors in development and stem cells.

scholarly journals Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression

2000 ◽  
Vol 20 (18) ◽  
pp. 6768-6778 ◽  
Author(s):  
Sara K. Oster ◽  
Wilson W. Marhin ◽  
Charlotte Asker ◽  
Linda M. Facchini ◽  
Patrick A. Dion ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Cell Types ◽  
Receptor Expression ◽  
Negative Regulator ◽  
Platelet Derived Growth Factor ◽  
Mrna Levels ◽  
Proliferating Cells ◽  
Receptor Complexes ◽  
Β Receptor

ABSTRACT Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as many other cell types. Interaction of PDGF BB with the PDGF β receptor (PDGF-βR) activates numerous signaling pathways and leads to a decrease in receptor expression on the cell surface. PDGF-βR downregulation is effected at two levels, the immediate internalization of ligand-receptor complexes and the reduction in pdgf-βr mRNA expression. Our studies show that pdgf-βr mRNA suppression is regulated by the c-myc proto-oncogene. Both constitutive and inducible ectopic Myc protein can suppress pdgf-βr mRNA and protein. Suppression of pdgf-βr mRNA in response to Myc is specific, since expression of the related receptorpdgf-αr is not affected. We further show that Myc suppresses pdgf-βr mRNA expression by a mechanism which is distinguishable from Myc autosuppression. Analysis of c-Myc-null fibroblasts demonstrates that Myc is required for the repression of pdgf-βr mRNA expression in quiescent fibroblasts following mitogen stimulation. In addition, it is evident that the Myc-mediated repression of pdgf-βr mRNA levels plays an important role in the regulation of basalpdgf-βr expression in proliferating cells. Thus, our studies suggest an essential role for Myc in a negative-feedback loop regulating the expression of the PDGF-βR.

scholarly journals Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain

1993 ◽  
Vol 268 (18) ◽  
pp. 13372-13377
Author(s):  
A. Ostman ◽  
M. Andersson ◽  
G. Bäckström ◽  
C.H. Heldin
Keyword(s):  
Growth Factor ◽  
Disulfide Bonds ◽  
Platelet Derived Growth Factor ◽  
Factor B
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