scholarly journals Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides

1991 ◽  
Vol 266 (23) ◽  
pp. 15091-15098
Author(s):  
J. Aikens ◽  
T.A. Dix
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Perhydroxyl Radical ◽  
Fatty Acid Hydroperoxides

The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation

1995 ◽  
Vol 61 ◽  
pp. 65-72 ◽  
Author(s):  
Lawrence J. Marnett ◽  
Allan L. Wilcox
Keyword(s):  
Lipid Peroxidation ◽  
Steady State ◽  
Fatty Acid ◽  
Hydroxyl Radical ◽  
Metal Complexes ◽  
Polyunsaturated Fatty Acid ◽  
Ring Opening ◽  
Steady State Concentration ◽  
State Concentration ◽  
Fatty Acid Hydroperoxides

Reaction of polyunsaturated fatty acid hydroperoxides with metal complexes generates lipid alkoxyl radicals and metal-oxo complexes. Lipid alkoxyl radicals are presumed to be the species responsible for metal-amplified lipid peroxidation because of the chemical analogy of simple organic alkoxyl radicals to the hydroxyl radical. However, polyunsaturated fatty acid alkoxyl radicals exhibit a rich and diverse chemistry that is dominated by intramolecular cyclization to epoxyallylic radicals. Studies described herein demonstrate that the equilibrium between cyclization and ring-opening of epoxyallylic radicals lies overwhelmingly toward cyclization. Thus lipid alkoxyl radicals have a steady-state concentration that is so low that their contribution to metal-amplified lipid peroxidation is insignificant. In fact, the species responsible for metal amplification of lipid peroxidation appears to be the epoxyperoxyl radical formed by coupling the epoxyallylic radical to molecular oxygen.

scholarly journals Isolation of lactic acid bacteria capable of reducing environmental alkyl and fatty acid hydroperoxides, and the effect of their oral administration on oxidative-stressed nematodes and rats

2019 ◽  
Author(s):  
Akio Watanabe ◽  
Takuro Yamaguchi ◽  
Kaeko Murota ◽  
Tadaaki Ishii ◽  
Junji Terao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lactic Acid ◽  
Fatty Acid ◽  
Lactic Acid Bacteria ◽  
Lactic Acid Bacterium ◽  
Alkyl Hydroperoxides ◽  
Oxygen Sensitive ◽  
Electron Reduction ◽  
Fatty Acid Hydroperoxides

AbstractReinforcement of hydroperoxide-eliminating activity in the intestines and colon should prevent associated diseases. We previously isolated a lactic acid bacterium,Pediococcus pentosaceusBe1, that facilitates a 2-electron reduction of hydrogen peroxide to water. In this study, we successfully isolated an alternative lactic acid bacterium,Lactobacillus plantarumP1-2, that can efficiently reduce environmental alkyl hydroperoxides and fatty acid hydroperoxides to their corresponding hydroxy derivatives through a 2-electron reduction. Each strain exhibited a wide concentration range with regard to the environmental reducing activity for each hydroperoxide. Given this, the two lactic acid bacteria were orally administered to the oxygen-sensitive short-lived nematode mutant, and this resulted in a significant expansion of its lifespan. This observation suggests thatP. pentosaceusBe1 andL. plantarumP1-2 inhibit internal oxidative stress. To determine the specific organs involved in this response, we performed a similar experiment in rats, involving induced lipid peroxidation by iron-overloading. We observed that onlyL. plantarumP1-2 inhibited colonic mucosa lipid peroxidation in rats with induced oxidative stress.

Specific markers of lipid peroxidation issued from n−3 and n−6 fatty acids

2004 ◽  
Vol 32 (1) ◽  
pp. 139-140 ◽  
Author(s):  
M. Guichardant ◽  
B. Chantegrel ◽  
C. Deshayes ◽  
A. Doutheau ◽  
P. Moliere ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Eicosatetraenoic Acid ◽  
Breakdown Product ◽  
High Enrichment ◽  
Urinary Sample ◽  
12 Lipoxygenase ◽  
Fatty Acid Hydroperoxides

Several markers of lipid peroxidation are available with different degrees of specificity, from malondialdehyde as a global marker, to F2-isoprostane, which is specifically produced from arachidonic acid. Among these, 4-hydroxynonenal is recognized as a breakdown product of fatty acid hydroperoxides, such as 15-hydroperoxy-eicosatetraenoic acid and 13-hydroperoxy-octade cadienoic acid from the n−6 fatty acids. Furthermore, 4-hydroxyhexenal (4-HHE) derives from n−3 fatty acid hydroperoxides. We have recently described the occurrence of 4-hydroxydodecadienal (4-HDDE) from the 12-lipoxygenase product of arachidonic acid 12-hydroperoxy-eicosatetraenoic acid. These three hydroxy-alkenals may be measured in human plasma by GC–MS, but they may partly be generated in the course of sampling, and the relative volatility of 4-HHE makes its measurement quite unreliable. We have successfully characterized and measured the stable oxidized carboxylic acid products from the hydroxy-alkenals 4-HNA, 4-HHA and 4-HDDA in urine. The ratio between 4-HHA and 4-HNA found in the same urinary sample might provide useful information on the location of lipid peroxidation, accounting for the high enrichment of the cerebrovascular system with docosahexaenoic acid, the main n−3 fatty acid in humans.

scholarly journals Role of Lipid Composition and Lipid Peroxidation in the Sensitivity of Fungal Plant Pathogens to Aluminum Chloride and Sodium Metabisulfite

2007 ◽  
Vol 73 (9) ◽  
pp. 2820-2824 ◽  
Author(s):  
Tyler J. Avis ◽  
Mélanie Michaud ◽  
Russell J. Tweddell
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Aluminum Chloride ◽  
Plant Pathogens ◽  
Membrane Lipids ◽  
Membrane Integrity ◽  
Sodium Metabisulfite ◽  
Fatty Acid Unsaturation ◽  
Fungal Plant Pathogens

ABSTRACT Aluminum chloride and sodium metabisulfite have shown high efficacy at low doses in controlling postharvest pathogens on potato tubers. Direct effects of these two salts included the loss of cell membrane integrity in exposed pathogens. In this work, four fungal potato pathogens were studied in order to elucidate the role of membrane lipids and lipid peroxidation in the relative sensitivity of microorganisms exposed to these salts. Inhibition of mycelial growth in these fungi varied considerably and revealed sensitivity groups within the tested fungi. Analysis of fatty acids in these fungi demonstrated that sensitivity was related to high intrinsic fatty acid unsaturation. When exposed to the antifungal salts, sensitive fungi demonstrated a loss of fatty acid unsaturation, which was accompanied by an elevation in malondialdehyde content (a biochemical marker of lipid peroxidation). Our data suggest that aluminum chloride and sodium metabisulfite could induce lipid peroxidation in sensitive fungi, which may promote the ensuing loss of integrity in the plasma membrane. This direct effect on fungal membranes may contribute, at least in part, to the observed antimicrobial effects of these two salts.

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

2015 ◽  
Vol 4 (3) ◽  
pp. 205 ◽  
Author(s):  
Shikha Saxena ◽  
KV Thimmaraju ◽  
PremC Srivastava ◽  
AyazK Mallick ◽  
Biswajit Das ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
In Pregnancy
Sign in / Sign up

Export Citation Format

Share Document