scholarly journals Elimination of adsorption effects in the analysis of water-soluble vitamins in pharmaceutical formulations by capillary electrophoresis

1999 ◽  
Vol 853 (1-2) ◽  
pp. 391-401 ◽  
Author(s):  
Lucas Fotsing ◽  
Marianne Fillet ◽  
Patrice Chiap ◽  
Philippe Hubert ◽  
Jacques Crommen
Keyword(s):  
Capillary Electrophoresis ◽  
Pharmaceutical Formulations ◽  
Water Soluble ◽  
Adsorption Effects

Pharmaceutical Polymers - A Review

2019 ◽  
Vol 9 (01) ◽  
pp. 27-33
Author(s):  
Naveen Kumar ◽  
Sonia Pahuja ◽  
Ranjit Sharma
Keyword(s):  
Drug Release ◽  
Industrial Revolution ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Taste Masking ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms ◽  
Pharmaceutical Applications ◽  
Pharmaceutical Industries

Humans have taken advantage of the adaptability of polymers for centuries in the form of resins, gums tars, and oils. However, it was not until the industrial revolution that the modern polymer industry began to develop. Polymers represent an important constituent of pharmaceutical dosage forms. Polymers have played vital roles in the formulation of pharmaceutical products. Polymers have been used as a major tool to manage the drug release rate from the formulations. Synthetic and natural-based polymers have found their way into the biomedical and pharmaceutical industries. Synthetic and Natural polymers can be produced with a broad range of strength, heat resistance, density, stiffness and even price. By constant research into the science and applications of polymers, they are playing an ever-increasing role in society. Diverse applications of polymers in the present pharmaceutical field are for controlled drug release. Based on solubility pharmaceutical polymers can be classified as water-soluble and water-insoluble. In general, the desirable polymer properties in pharmaceutical applications are film forming, adhesion, gelling, thickening, pH-dependent solubility and taste masking. General pharmaceutical applications of polymers in various pharmaceutical formulations are also discussed

scholarly journals Chiral Selectors in Capillary Electrophoresis: Trends During 2017–2018

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1135 ◽  
Author(s):  
Raymond B. Yu ◽  
Joselito P. Quirino
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Mass ◽  
Chiral Separation ◽  
Chiral Separations ◽  
Water Soluble ◽  
Resonance Spectroscopy ◽  
Electrokinetic Chromatography ◽  
Chiral Selectors ◽  
Analytical Technique ◽  
Pharmaceutical Industries

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis

2005 ◽  
Vol 39 (3-4) ◽  
pp. 559-563 ◽  
Author(s):  
Demetrius G. Themelis ◽  
Anastasios V. Trellopoulos ◽  
Paraskevas D. Tzanavaras ◽  
Bo Karlberg
Keyword(s):  
Capillary Electrophoresis ◽  
Pharmaceutical Formulations ◽  
Synthetic Estrogen

Distinction of water-soluble constituents between natural and cultured Cordyceps by capillary electrophoresis

Phytomedicine ◽  
2004 ◽  
Vol 11 (7-8) ◽  
pp. 684-690 ◽  
Author(s):  
S.P. Li ◽  
Z.H. Song ◽  
T.T.X. Dong ◽  
Z.N. Ji ◽  
C.K. Lo ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Water Soluble

Polymeric precipitation inhibitor as an effective trigger to convert supersaturated into supersaturable state in vivo

2019 ◽  
Vol 10 (9) ◽  
pp. 599-608
Author(s):  
Dilpreet Singh ◽  
Manmeet Singh ◽  
Abhay Tharmatt ◽  
Ashok K Tiwary ◽  
Neena Bedi
Keyword(s):  
Oral Absorption ◽  
Extended Period ◽  
Pharmaceutical Formulations ◽  
Water Soluble ◽  
Delayed Response ◽  
Supersaturated State ◽  
Drug Precipitation ◽  
Precipitation Inhibitor ◽  
Selection Of

The supersaturated state of the drug in vivo is thermodynamically unstable resulting in a delayed response and reduced efficacy. The use of polymeric precipitation inhibitor (PPI) has been demonstrated as an effective trigger for the conversion of supersaturated state to supersaturable state for improving solubilization, thermodynamic maintenance of drug concentration and oral absorption of poorly water-soluble compounds. PPI retards drug precipitation and provides a kinetically stabilized supersaturation state for an extended period in gastric and intestinal fluids. However, the selection of appropriate PPI and understanding its mechanism is a challenge for formulating a stable pharmaceutical formulation. The present review is aimed at understanding the intricacies of selecting PPIs and their applications in pharmaceutical formulations.

Determination of Ofloxacin Enantiomers in Pharmaceutical Formulations by Capillary Electrophoresis

2007 ◽  
Vol 31 (3) ◽  
pp. 348-360 ◽  
Author(s):  
Abdalla A. Elbashir ◽  
Bahruddin Saad ◽  
Abdussalam Salhin Mohamed Ali ◽  
Muhammad Idiris Saleh ◽  
Hassan Y. Aboul‐Enein
Keyword(s):  
Capillary Electrophoresis ◽  
Pharmaceutical Formulations ◽  
Ofloxacin Enantiomers

scholarly journals Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 65 ◽  
Author(s):  
Ana Santos ◽  
Francisco Veiga ◽  
Ana Figueiras
Keyword(s):  
Drug Efficacy ◽  
Aqueous Solubility ◽  
Pharmaceutical Formulations ◽  
The United States ◽  
Water Soluble ◽  
European Medicines Agency ◽  
Uniform Size ◽  
Pharmaceutical Excipients ◽  
Synthesis Properties ◽  
Water Soluble Drugs

The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

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