Diagnosis of congenital toxoplasmosis in the neonatal period: A multicenter evaluation

At the Children's Hospital, University of Helsinki, 205 children with infantile spasms who were born between 1960 and 1976 were studied in a search for the factors responsible. In 11 children (5%) the infantile spasms were possibly associated with cytomegalovirus (CMV) infection. The number may actually have been considerably higher, as no systematic search was made for CMV, especially in the early years. In four of the 11 children, the infection was probably congenital, and was the most likely cause of the spasms. One of the remaining seven children had congenital toxoplasmosis and the simultaneous CMV infection was probably also congenital. The children with congenital CMV infection exhibited severe clinical symptoms in the neonatal period or in early infancy. Two frequent symptoms were persistent tremor and meningoencephalitis. Later, all five children were severely mentally retarded and had spastic tetraplegia and small heads; three of them had optic atrophy and were blind. In the other six children, the CMV infection was probably acquired, the clinical symptoms being less severe, and the spasms may have been caused by another factor. In two of the 11 cases, immunosuppressive therapy (ACTH treatment generally given for infantile spasms) seems to have caused a fulminant CMV infection. Two children with CMV infection still show signs of a slow virus infection in the central nervous system many years later.

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Congenital Toxoplasmosis: A Case Study

Forbes Journal of Medicine ◽

10.5222/forbes.2021.77486 ◽

2021 ◽

Author(s):

Ferda Kazancı ◽

Nursel Yurttutan ◽

Ayşegül Çomez ◽

Sadık Yurttutan

Keyword(s):

Neonatal Period ◽

Congenital Toxoplasmosis ◽

Pcr Analysis ◽

Fluid Sample ◽

Maternal Infections ◽

Bodily Fluids ◽

Slow Progression ◽

Ocular Disorders ◽

Acute Toxoplasmosis

Acute toxoplasmosis infections that develop during pregnancy can be detrimental to the developing fetus. Although the etiology may derive from various factors, the primary cause of these maternal infections is the consumption of contaminated meat or water. The transmission of the infection to the fetus may result in devastating neurological and ocular disorders. In this article, we present a case of congenital toxoplasmosis that occurred on the 3rd live birth of a 37 year old mother’s 4th pregnancy. During the pregnancy, the mother received Spiramycin as she was (+) for Toxoplasma IgM. In the initial evaluation of the neonate, there were no findings associated with toxoplasmosis. A CSF (cerebrospinal fluid) sample was taken and the patient was followed-up, a re-evaluation was conducted as the patient’s PCR analysis was positive; the diagnosis was confirmed by the presence of chorioretinitis and intracranial calcification. In conclusion, congenital toxoplasmosis is an insidious disease with a slow progression. Physical examination findings may not be apparent during the early neonatal period. These patients should be carefully examined, periodically followed up, and their bodily fluids should be tested.

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CONGENITAL TOXOPLASMOSIS. CLINICAL OBSERVATION

Journal of the Grodno State Medical University ◽

10.25298/2221-8785-2020-18-5-611-618 ◽

2020 ◽

Vol 18 (5) ◽

pp. 611-618

Author(s):

A. I. Paltseva ◽

◽

V. L. Zverko ◽

L. N. Sinitsa ◽

S. M. Ponomarenko ◽

...

Keyword(s):

Early Diagnosis ◽

Clinical Observation ◽

Neonatal Period ◽

Congenital Toxoplasmosis ◽

Physical Development ◽

Culture Contact ◽

Laboratory Research ◽

Correct Interpretation ◽

Review Of The Literature ◽

Early Prevention

The article presents a review of the literature and clinical observation of a newborn with congenital toxoplasmosis. The difficulties of diagnosing the asymptomatic form of congenital toxoplasmosis in the early neonatal period in one of the twins of a newborn are discussed. The authors note that a careful collection of antenatal history (nutritional culture, contact with a feline), analysis of the patient’s physical development, correct interpretation of the clinical manifestation, data from laboratory research methods and clinical alertness for congenital TORCH complex infection will contribute to the early diagnosis of the disease. Timely etiopathogenetic therapy will allow for effective treatment and early prevention of disabling complications in a patient.

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Childhood diaphragmatic hernias presenting after the neonatal period

Clinical Radiology ◽

10.1016/s0009-9260(88)80377-5 ◽

1988 ◽

Vol 39 (2) ◽

pp. 237-244 ◽

Cited By ~ 5

Author(s):

L BERMAN ◽

D STRINGER ◽

S EIN ◽

B SHANDLING

Keyword(s):

Neonatal Period ◽

Diaphragmatic Hernias

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A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

Journal of Pediatric Genetics ◽

10.1055/s-0040-1719161 ◽

2020 ◽

Author(s):

Hasan Akduman ◽

Dilek Dilli ◽

Serdar Ceylaner

Keyword(s):

Mutation Analysis ◽

Autosomal Recessive ◽

Glucose Transporter ◽

Neonatal Period ◽

Autosomal Recessive Disorder ◽

Homozygous Mutation ◽

New Mutation ◽

Early Neonatal Period ◽

Sodium Dependent ◽

Hypernatremic Dehydration

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.

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FEMALE ENDOCRINE CONTROL MECHANISMS DURING THE NEONATAL PERIOD

Acta Endocrinologica ◽

10.1530/acta.0.0700396 ◽

1972 ◽

Vol 70 (2) ◽

pp. 396-408 ◽

Cited By ~ 1

Author(s):

K.-D. Schulz ◽

H. Haarmann ◽

A. Harland

Keyword(s):

Protein Synthesis ◽

Reproductive System ◽

Rna Synthesis ◽

Neonatal Period ◽

High Dose ◽

Female Reproductive System ◽

Endocrine Control ◽

Hypothalamic Region ◽

Rna And Protein Synthesis ◽

Physiological Dose

ABSTRACT The present investigation deals with the oestrogen-sensitivity of the female reproductive system during the neonatal period. Newborn female guinea pigs were used as test animals. At different times after a single subcutaneous injection of a physiological dose of 0.1 μg or an unphysiologically high dose of 10 μg 17β-oestradiol/100 g body weight, the RNA- and protein-synthesis was examined in the hypothalamic region, pituitary, cerebral cortex, liver, adrenal gland, ovary and uterus. With a physiological dose an increase in organ weight, protein content, RNA-and protein-synthesis was found only in the uterus. These alterations turned out to be dose-dependent. In addition to the findings in the uterus an inhibition of the aminoacid incorporation rate occurred in the liver following the injection of the high oestradiol dose. As early as 1 hour after the administration of 0.1 μg 17β-oestradiol an almost 100% increase in uterine protein synthesis was detectable. This result demonstrates a high oestrogen-sensitivity of this organ during the neonatal period. All the other organs of the female reproductive system such as the hypothalamus, pituitary and ovary did not show any oestrogen response. Therefore the functional immaturity of the uterus during post partem life is not the result of a deficient hormone sensitivity but is correlated with the absence of a sufficient hormonal stimulus at this time. The investigation on the effects of actinomycin resulted in different reactions in the uterus and liver. In contrast to the liver a paradoxical actinomycin effect was found in the uterus after treatment with actinomycin alone. This effect is characterized by a small inhibition of RNA-synthesis and a 50% increase in protein synthesis. The treatment of the newborn test animals with actinomycin and 17β-oestradiol together abolished the oestrogen-induced stimulation of the uterine RNA-and protein-synthesis. Consequently, the effect of oestrogens during the neonatal period is also connected with the formation of new proteins via an increased DNA-directed RNA-synthesis.

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Type B Interrupted Aorta in an Adult Patient

The Heart Surgery Forum ◽

10.1532/hsf98.2013309 ◽

2014 ◽

Vol 17 (2) ◽

pp. 80

Author(s):

Ahmet Ozkara ◽

Mehmet Ezelsoy ◽

Levent Onat ◽

Ilhan Sanisoglu

Keyword(s):

Cardiopulmonary Bypass ◽

Aortic Arch ◽

Collateral Circulation ◽

Neonatal Period ◽

Interrupted Aortic Arch ◽

Complete Loss ◽

Posterolateral Thoracotomy ◽

Type B ◽

Case Presentation ◽

Descending Aorta

Introduction: Interrupted aortic arch is a rare congenital malformation characterized by a complete loss of luminal continuity between the ascending and descending aorta. It is often diagnosed during the neonatal period.Case presentation: We presented a 51-year-old male patient with interrupted aortic arch type B who was treated successfully with posterolateral thoracotomy without using cardiopulmonary bypass.Conclusion: The prognosis for interrupted aortic arch depends on the associated congenital anomalies, but the outcome is usually very poor unless there is surgical treatment. Survival into adulthood depends on the development of collateral circulation.

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