Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome caused by insulin secretion abnormalities, insulin action, or both. Gene polymorphism is a risk factor of T2DM. AIM: This study aims to see the role of Apa-I Vitamin D receptor gene polymorphism on T2DM. METHODS: This study was an analytic observational with a case–control approach, consisting of 70 T2DM patients and 70 healthy subjects as a control. Genotyping of the Apa-I Vitamin D receptor gene polymorphism was performed using the polymerase chain reactions-restriction fragment length polymorphisms method. The role of the Apa-I Vitamin D receptor gene polymorphism and the risk of T2DM were analyzed using the Chi-square test. RESULTS: The results showed that there was a significant association between codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism with the risk of T2DM (p < 0.05; odds ratio [OR] = 0.204, 95% confidence interval [CI] = 0.063–0.662; OR = 0.337, 95% CI = 0.113–1.004; OR = 0.367, 95% CI = 0.180–0.747, respectively), but not in codominant (GT genotype) and over-dominant models (p > 0.05). CONCLUSION: This study shows a role of the codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism on T2DM, but not in codominant (GT genotype) and over-dominant models.

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The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population

Journal of Human Genetics ◽

10.1007/s100380200060 ◽

2002 ◽

Vol 47 (8) ◽

pp. 413-418 ◽

Cited By ~ 54

Author(s):

R. Medeiros ◽

A. Morais ◽

A. Vasconcelos ◽

S. Costa ◽

D. Pinto ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

European Population ◽

Vitamin D Receptor Gene ◽

Receptor Gene Polymorphisms

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Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis

Experimental and Molecular Pathology ◽

10.1016/j.yexmp.2008.10.002 ◽

2009 ◽

Vol 86 (1) ◽

pp. 69-73 ◽

Cited By ~ 21

Author(s):

M. Vidyarani ◽

P. Selvaraj ◽

S. Raghavan ◽

P.R. Narayanan

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Regulatory Role ◽

Vitamin D Receptor Gene ◽

Gene Variants ◽

Dihydroxyvitamin D3 ◽

Granzyme A

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The Role of the rs1544410 Polymorphism of Vitamin D Receptor Gene in Breast Cancer Susceptibility

Cell Biochemistry and Biophysics ◽

10.1007/s12013-014-0155-6 ◽

2014 ◽

Vol 70 (3) ◽

pp. 1951-1956 ◽

Cited By ~ 2

Author(s):

Xiaorui Li ◽

Xiaoqing Huo ◽

Weiwei Li ◽

Qinghui Yang ◽

Ying Wang ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Vitamin D Receptor ◽

Cancer Susceptibility ◽

Receptor Gene ◽

Breast Cancer Susceptibility ◽

Vitamin D Receptor Gene

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THE ROLE OF VITAMIN D, VITAMIN D RECEPTOR GENE FOKI POLYMORPHISM, AND CATHELICIDIN IN TUBERCULOSIS INFECTION IN CHILDREN

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019.v11s6.33575 ◽

2019 ◽

pp. 125-128

Author(s):

FITRISIA AMELIN ◽

FINNY FITRI YANI ◽

RIZANDA MACHMUD

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Plasma Levels ◽

Receptor Gene ◽

Demographic Data ◽

Tuberculosis Infection ◽

Sputum Smear ◽

Vitamin D Receptor Gene ◽

Foki Polymorphism

Objective: Recent studies have reported that vitamin D has an important role in tuberculosis. Polymorphism of single nucleotide polymorphism (SNP) rs2228570 or FokI will generate proteins with various amino acid lengths, and affect the molecular physiological roles of vitamin D. Cathelicidin acts as an antimicrobial directly against Mycobacterium tuberculosis (Mtb) and mediator autophagy by macrophages induced by vitamin D. This study aims to determine the role of vitamin D, vitamin D receptor gene SNP rs2228570 (FokI), and plasma levels of cathelicidin in children with tuberculosis infection. Methods: This cross-sectional was conducted on children aged £14 y who had close contacts with an adult who had sputum smear positive for acid-fast bacilli indicating pulmonary TB. The children were divided into two groups: those with and those without TB infection. Demographic data and blood samples were taken from children participating in this study to examine polymorphisms and cathelicidin plasma levels, and to determine the association between these levels in children with and without TB infection. Results: There were no differences in the proportion of genotype and allele of SNP rs2228570 vitamin D receptor gene (FokI), polymorphisms of VDR, and cathelicidin plasma levels between children with and without TB infection (p>0.05). However, nutritional status and levels of cathelicidin by age category increased the risk of TB infection (p<0.05). Conclusion: Cathelicidin level in children with TB infection lower than without. Vitamin D and FokI polymorphism did not play role in TB infection.

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