Effects of isotonic saline solution resuscitation on blood coagulation in uncontrolled hemorrhage

Surgery ◽  
1996 ◽  
Vol 119 (5) ◽  
pp. 528-533 ◽  
Author(s):  
Jeffrey B. Selby ◽  
James E. Mathis ◽  
Carrie F. Berry ◽  
Frederick N. Hagedorn ◽  
Hana P. Illner ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Uncontrolled Hemorrhage

scholarly journals The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug

2006 ◽  
Vol 43 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Afonso Luiz Villa ◽  
Ceneviva Reginaldo ◽  
Fernanda Viaro ◽  
Fernando Ramalho ◽  
Antonio Dorival Campos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Isosorbide Dinitrate ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Nitric Oxide Donor ◽  
Group Iii ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Gastric Mucous ◽  
Lesion Index

BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AIM: To define a possible cytoprotective effect of a nitric oxide donor, isosorbide dinitrate, on the gastric mucous of rats submitted to non-steroidal anti-inflammatory drugs ketoprofen treatment. METHODS: Adult male Wistar rats, previously submitted to starvation for 24 hours and divided in three groups: group I (standard): animals that received isotonic saline solution intragastric by gavage and intravenous. Group II (control-ketoprofen): animals that received isotonic saline solution intragastric by gavage and ketoprofen intravenous. Group III (nitrate/ketoprofen): animals that received 2mM solution of isosorbide dinitrate intragastric by gavage and ketoprofen intravenous. Later on, these animals were sacrificed and had their stomach removed and submitted to macroscopical, microscopical and biochemical studies. The evaluated parameters were: a) gastric lesion index; b) gastric mucous layer thickness; c) gastric tissue nitrate/nitrite (NOx) concentration and d) gastric tissue malondialdehyde concentration. RESULTS: a) Gastric lesion index evaluation showed a smaller statistically significant incidence on the animals of group III; b) group III showed a thicker mucous layer, which also was statistically significant, when compared to group II; c) the variation on tissue nitrate/nitrite concentration was similar in all three groups, without statistical significance when compared to each other. CONCLUSION: Isosorbide dinitrate has a cytoprotective activity on the gastric mucosa of rats submitted to ketoprofen action.

Fluid Movement Across the Wall of the Small Intestine in Vitro

1956 ◽  
Vol 187 (2) ◽  
pp. 244-246 ◽  
Author(s):  
T. Hastings Wilson
Keyword(s):  
Small Intestine ◽  
Sodium Chloride ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Bicarbonate Secretion ◽  
Serosal Side ◽  
Fluid Movement ◽  
Mucosal Side

Small sacs of everted jejunum of the hamster were incubated in sugar free bicarbonate-saline solution in vitro. Both fluid and sodium chloride moved across the wall of the intestine from mucosal to serosal side. This movement of isotonic saline solution across the intestine was inhibited anaerobically. A small bicarbonate secretion was noted in the direction of serosal to mucosal side.

Drinking-induced thermoregulatory panting in rehydrated sheep: influences of oropharyngeal/esophageal signals, core temperature, and thirst satiety

2009 ◽  
Vol 296 (6) ◽  
pp. R1881-R1888 ◽  
Author(s):  
M. J. McKinley ◽  
F. Weissenborn ◽  
M. L. Mathai
Keyword(s):  
Drinking Water ◽  
Body Temperature ◽  
Core Temperature ◽  
Heat Load ◽  
Water Deprivation ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Cool Water ◽  
Rapid Fall

Dehydrated mammals conserve body water by reducing thermoregulatory evaporative cooling responses e.g., panting and sweating. Increased core temperature (Tc) may result. Following rehydration and correction of fluid deficits, panting and sweating commence. We investigated the role of oropharyngeal/esophageal, postabsorptive and thermal signals in the panting response, and reduced Tc that occurs when unshorn sheep drink water following water deprivation for 2 days (ambient temperature 20°C). Ingestion of water (at body temperature) resulted in increased respiratory rate (panting) and reduced Tc within 4 min that persisted for at least 90 min. Initially, a similar panting response and reduced Tc occurred following rehydration by drinking isotonic saline solution, but panting was not sustained after 20 min, and Tc began to rise again. Rehydration by intraruminal administration of water, without any drinking, resulted in delayed panting and fall in Tc. Intraruminal infusion of saline was ineffective. Rehydration by drinking cool water (20°C) resulted in a rapid fall in Tc without increased panting. Shorn sheep had lower basal Tc that did not increase during 2 days of water deprivation, and they did not pant on rehydration by drinking water. Our results indicate that signals from the oropharyngeal and/or esophageal region associated with the act of drinking play a crucial role in the initial 20–30 min of the panting response to rehydration. Postabsorptive factors most likely reduced plasma tonicity and cause continued panting and further reduction in Tc. Tc also influences rehydration-induced panting. It occurs only if sheep incur a heat load during bodily dehydration.

The stress effects of a single injection of isotonic saline solution: systemic (blood) and central (frontal cortex and dorsal and ventral hippocampus)

2016 ◽  
Vol 10 (2) ◽  
pp. 115-119 ◽  
Author(s):  
S. V. Freiman ◽  
M. V. Onufriev ◽  
M. Yu. Stepanichev ◽  
Yu. V. Moiseeva ◽  
N. A. Lazareva ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Saline Solution ◽  
Single Injection ◽  
Isotonic Saline ◽  
Ventral Hippocampus ◽  
Systemic Blood ◽  
Stress Effects

scholarly journals “WATER DIURESIS” PRODUCED DURING RECUMBENCY BY THE INTRAVENOUS INFUSION OF ISOTONIC SALINE SOLUTION 1

1951 ◽  
Vol 30 (8) ◽  
pp. 862-868 ◽  
Author(s):  
Maurice B. Strauss ◽  
Robert K. Davis ◽  
Jack D. Rosenbaum ◽  
Elsie C. Rossmeisl
Keyword(s):  
Intravenous Infusion ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Water Diuresis

scholarly journals ALTERATIONS IN THE IONIC COMPOSITION OF ISOTONIC SALINE SOLUTION INSTILLED INTO THE COLON 1

1953 ◽  
Vol 32 (5) ◽  
pp. 444-448 ◽  
Author(s):  
Angelo D'Agostino ◽  
Wyland F. Leadbetter ◽  
William B. Schwartz
Keyword(s):  
Saline Solution ◽  
Ionic Composition ◽  
Isotonic Saline

scholarly journals Sodium bicarbonate versus isotonic saline solution to prevent contrast-induced nephropathy : a systematic review and meta-analysis

2015 ◽  
pp. 90-103 ◽  
Author(s):  
Carlos Andres Zapata Chica ◽  
Lina Maria Serna Higuita ◽  
John Fredy Nieto Ríos ◽  
Fabian David Casas Arroyave ◽  
Jorge Hernando Donado Gómez
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Sodium Bicarbonate ◽  
Replacement Therapy ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Kidney Injury ◽  
Contrast Induced Nephropathy ◽  
Randomized Controlled Studies

Introduction: Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. Objective: To compare the effectiveness of sodium bicarbonate vs. hydration using 0.9% saline solution to prevent contrast-induced acute kidney injury. Methods: A systematic review of studies registered in the Cochrane, Pubmed, Medline, Lilacs, ScielO and Embase databases was conducted. Randomized controlled studies that evaluated the use of 0.9% saline solution vs. sodium bicarbonate to prevent contrast-induced nephropathy were included. Results: A total of 22 studies (5,686 patients) were included. Sodium bicarbonate did not decrease the risk of contrast-induced nephropathy (RD= 0.00; 95% CI= -0.02 to 0.03; p= 0.83; I2= 0%). No significant differences were found in the demand for renal replacement therapy (RD= 0.00; 95% CI= -0.01 to 0-01; I2= 0%; p= 0.99) or in mortality (RD= -0.00; 95% CI= -0.001 to 0.001; I2= 0%; p= 0.51). Conclusions: Sodium bicarbonate administration is not superior to the use of 0.9% saline solution for preventing contrast-induced nephropathy in patients with risk factors, nor is it better at reducing mortality or the need for renal replacement therapy.

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