The Edinburgh Postnatal Depression Scale (EPDS) and the detection of major depressive disorders in early postpartum: some concerns about false negatives

2000 ◽  
Vol 61 (1-2) ◽  
pp. 107-112 ◽  
Author(s):  
N. Guedeney ◽  
J. Fermanian ◽  
J.D. Guelfi ◽  
R.C. Kumar
Keyword(s):  
Postnatal Depression ◽  
Depressive Disorders ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Major Depressive ◽  
False Negatives ◽  
Early Postpartum ◽  
Major Depressive Disorders

scholarly journals Validation of the Edinburgh postnatal depression scale (EPDS) for screening of major depressive episode among adults from the general population

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Alicia Matijasevich ◽  
Tiago N Munhoz ◽  
Beatriz Franck Tavares ◽  
Ana Paula Pereira Neto Barbosa ◽  
Diego Mello da Silva ◽  
...  
Keyword(s):  
General Population ◽  
Depressive Episode ◽  
Postnatal Depression ◽  
Major Depressive Episode ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Major Depressive

scholarly journals Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiang Gao ◽  
Zuoli Sun ◽  
Guangwei Ma ◽  
Yuhong Li ◽  
Min Liu ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Disease Severity ◽  
Depressive Disorders ◽  
Transmembrane Protein ◽  
Depression Scale ◽  
The Elderly ◽  
First Episode ◽  
Hamilton Depression Scale ◽  
Major Depressive ◽  
Major Depressive Disorders

Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression. Although the Klotho gene encodes α-Klotho, a single transmembrane protein with intracellular and extracellular domains, the relationship between Klotho gene polymorphism and circulating α-Klotho levels in patients with major depressive disorder (MDD) is not clear.Methods: A total of 144 MDD patients and 112 age-matched healthy controls were included in this study. The Klotho genetic polymorphisms (rs9536314, rs9527025, and rs9315202) and plasma α-Klotho levels were measured by PCR and ELISA, respectively. The severity of depressive symptoms was estimated using the Hamilton Depression Scale (HAMD).Results: We found a significantly lower level of plasma α-Klotho in the MDD patients than in controls. Among them, only elderly MDD patients (first episode) showed significantly lower α-Klotho levels than the age-matched controls, while elderly recurrent and young MDD patients showed no difference in plasma α-Klotho levels from age-matched controls. The young MDD group showed a significantly earlier onset age, higher plasma α-Klotho levels, and lower HAMD scores than those in the elderly MDD group. While the plasma α-Klotho levels were higher in rs9315202 T alleles carrier regardless age or sex, the rs9315202 T allele was negatively correlated with disease severity only in the elderly MDD patients.Conclusion: The results of our study showed that only elderly MDD patients showed a decrease in plasma α-Klotho levels along with an increase in disease severity as well as an association with the number of rs9315202 T alleles, and not young MDD patients compared to age-matched controls. Our data suggest that circulating α-Klotho levels combined with Klotho genetic polymorphisms are important in elderly MDD patients, particularly carriers of the Klotho gene rs9315202 T allele.

scholarly journals Validation of the Lithuanian version of the Edinburgh Postnatal Depression Scale

Medicina ◽  
2009 ◽  
Vol 45 (7) ◽  
pp. 544 ◽  
Author(s):  
Adomas Bunevičius ◽  
Laima Kusminskas ◽  
Robertas Bunevičius
Keyword(s):  
Internal Consistency ◽  
Roc Curve ◽  
Postnatal Depression ◽  
Depressive Disorders ◽  
Edinburgh Postnatal Depression Scale ◽  
Short Form ◽  
Depression Scale ◽  
Cutoff Score ◽  
Good Reliability ◽  
Major Health Problem

Depression is prevalent postpartum and is a major health problem. Objective. In this study, we aimed to evaluate how precise the Edinburgh Postnatal Depression Scale (EPDS) is in screening for depressive disorders postpartum. Materials and methods. A random sample of 94 women was interviewed two weeks postpartum using the Composite International Diagnostics Interview Short-Form (CIDI-SF). In addition, they filled in the EPDS. We evaluated (a) internal consistency of the EPDS by the means of Cronbach’s alpha coefficient; (b) area under the ROC curve, sensitivity, specificity of the EPDS against the CIDI-SF diagnoses of depressive disorders. Results. The internal consistency of the EPDS was 0.83. The optimal cutoff score of the EPDS for screening CIDI-SF diagnoses of depressive disorders was found to be 7 and more with an area under the ROC curve of 0.83, sensitivity of 92%, and specificity of 73%. Conclusions. The EPDS has a good reliability as a screening instrument, and a cutoff score of 7 and more has to be used in screening for postpartum depressive disorders.

Screening for Postnatal Depression in Routine Primary Care: Properties of the Edinburgh Postnatal Depression Scale in an Australian sample

2005 ◽  
Vol 39 (9) ◽  
pp. 833-839 ◽  
Author(s):  
Jeannette Milgrom ◽  
Jennifer Ericksen ◽  
Lisa Negri ◽  
Alan W. Gemmill
Keyword(s):  
Primary Care ◽  
Postnatal Depression ◽  
Depressive Disorders ◽  
Edinburgh Postnatal Depression Scale ◽  
Screening Program ◽  
Post Partum ◽  
Depression Scale ◽  
Absolute Difference ◽  
Roc Curve Analysis ◽  
Dsm Iv

Objectives: First, to explore the utility of the Edinburgh Postnatal Depression Scale (EPDS) in routine primary care through a large community screening program. Next, to compare administration of a second EPDS versus the Beck Depression Inventory (BDI) in identifying postnatal depression in the prescreened population. Method: Screening with the EPDS through Maternal and Child Health Centres at 4 months post-partum. Women scoring ≥12 were assessed against DSM-IV criteria and completed a BDI and a second EPDS. These data were subjected to receiver operating characteristic (ROC) analyses. Results: Of 4148 screened, 533 (12.8%) scored ≥12. Of these, 344 were assessed against DSM-IV criteria: 193 (56%) – major depressive disorder; 67 (20%) – other diagnoses that incorporated depression. Positive predictive value at screening was therefore 76%. Another 45 (13%) had non-depressive disorders and 39 (11%) were psychiatric non-cases. The BDI was the better diagnostic instrument in the prescreened population, having a significantly higher efficiency as quantified by ROC curve analysis, though the absolute difference in efficiency was small (approximately 6%). Conclusions: Screening with the EPDS integrated well into routine primary care. Twostep screening offers one way of achieving acceptable balances of operational simplicity and diagnostic accuracy.

Screening for Adjustment Disorders and Major Depressive Disorders in Cancer In-Patients

1990 ◽  
Vol 156 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Darius Razavi ◽  
Nicole Delvaux ◽  
Christine Farvacques ◽  
Edmond Robaye
Keyword(s):  
Depressive Disorders ◽  
False Positive Rate ◽  
Screening Method ◽  
Depression Scale ◽  
Rate Sensitivity ◽  
True Positive Rate ◽  
Adjustment Disorders ◽  
Major Depressive ◽  
Positive Rate ◽  
Major Depressive Disorders

The Hospital Anxiety and Depression Scale (HADS), a four-point, 14-item questionnaire, was tested as a screening method for adjustment disorders and major depressive disorders in a sample of 210 cancer in-patients. A receiver operating characteristic (ROC) analysis was performed, giving the relationship between the true positive rate (sensitivity) and the false positive rate (1 – specificity). This makes it possible to choose an optimal cut-off point that takes into account the costs and benefits of treatment of psychological distress. For screening for major depressive disorders only, a cut-off score of 19 gave 70% sensitivity and 75% specificity. For screening for adjustment disorders and major depressive disorders taken together, a cut-off score of 13 gave 75% sensitivity and 75% specificity. HADS appears in this study to be a simple, sensitive and specific tool for screening for psychiatric disorders in an oncology in-patient population.

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