S35-3 HOSPITAL CARE OF PATIENTS WITH ACUTE CORONARY SYNDROME (UNSTABLE ANGINA AND NON-ST ELEVATION MYOCARDIAL INFARCTION) – PRELIMINARY RESULTS FROM THE ACCORD REGISTRY

Background: One third of all deaths worldwide are attributed to acute coronary syndrome. The thrombolysis in Myocardial Infarction Risk Score is used to assess the risk of mortality and major adverse outcomes in this population. This study aimed to assess and compare the morbidity and mortality differences rate between Saudi and non-Saudi patients with acute coronary syndrome. Methods: This retrospective study was conducted at the coronary care unit of King Abdulaziz University Hospital. All acute coronary syndrome cases were enrolled and assessed using the thrombolysis in Myocardial Infarction Risk Score. Results: 242 cases were divided as 98 ST-elevation myocardial infarction cases and 144 unstable angina/non ST-elevation myocardial infarction. Among ST-elevation myocardial infarction patients 21 were Saudi patients and 77 were non-Saudi patients with the median thrombolysis in myocardial infarction risk score for Saudi was 5 and for non-Saudi 3.5 (P = 0.6). Unstable angina/non ST-elevation myocardial infarction cases had 47 Saudi patients and 94 non-Saudi patients with the median score was 4.2 for Saudis versus 4.5 for non-Saudis (P = 0.4). Conclusion: Overall thrombolysis in myocardial infarction were higher in Saudis with ST-elevation myocardial infarction than non-Saudis, and higher for non-Saudis with unstable angina/non ST-elevation myocardial infarction than Saudis. However, the difference was not significant (p = 0.6, p = 0.4). The 30 days and one-year mortality as well as major adverse cardiac events were similar between the two groups in ST-elevation myocardial infarction (P = 0.4 and 0.7) and unstable angina/non ST-elevation myocardial infarction population (P = 0.3 and 0.3).

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Trends and in-hospital mortality of Acute Coronary Syndrome at Shahid Gangalal National Heart Centre, Kathmandu, Nepal during 2001-2012

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v3i1.10698 ◽

2014 ◽

Vol 3 (1) ◽

pp. 23-26

Author(s):

Chandra Mani Adhikari ◽

Deewakar Sharma ◽

Rabi Malla ◽

Sujeeb Rajbhandari ◽

Roshan Raut ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Hospital Mortality ◽

Unstable Angina ◽

St Elevation Myocardial Infarction ◽

St Segment Elevation ◽

Coronary Syndrome ◽

National Heart ◽

St Segment ◽

St Elevation

Background and aims: Acute coronary syndrome (ACS), which comprises acute ST-segment elevation myocardial infarction, non-ST segment elevation myocardial infarction and unstable angina is a major health problem and represents a large number of hospitalizations annually worldwide. We aim to describe pattern of the ACS admission and in-hospital mortality at tertiary national heart centre of the country. Methods: A hospital database was used to analyze all 7424 patients admitted in coronary care unit of the centre for ACS from September 2001 till December 2012. We evaluated trend of ACS admission and in-hospital mortality. Results: Five thousand three hundred ninety one (72.6%) were male and two thousand thirty three (27.4%) were female. Patient of 21years to 98 years were admitted for ACS .Four thousand five hundred and ninety nine(61.9%) patient were admitted due to ST elevation myocardial infarction, whereas one thousand nine hundred and thirteen (25.8%) were admitted for Unstable angina and nine hundred twelve (12.3%) were admitted for Non ST elevation myocardial infarction. In-hospital mortality was 5.74% for acute coronary syndrome. There was significant difference in in-hospital mortality between ST elevation myocardial infarction (7.76%), Non ST segment elevation acute coronary syndrome (3.61%) and Unstable Angina (1.88%).There is a gradual increase in Primary Percutaneous Coronary intervention as a mode of reperfusion therapy whereas there is a decrease in the rate of thrombolysis. Conclusion: Our study provides us some important information about the trend and in-hospital mortality rate in national heart centre. Though it is a single centre study can provide us the insight of the ACS outcome. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10698 Journal of Advances in Internal Medicine 2014;03(01):23-26

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Hubungan Kadar Gula Darah saat Masuk Rumah Sakit dengan Jenis Sindroma Koroner Akut di RS Dr. M. Djamil Padang

Jurnal Kesehatan Andalas ◽

10.25077/jka.v4i2.267 ◽

2015 ◽

Vol 4 (2) ◽

Author(s):

Willy Valerian ◽

Masrul Syafri ◽

Zelly Dia Rofinda

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Angina Pectoris ◽

Unstable Angina ◽

Blood Sugar ◽

St Elevation Myocardial Infarction ◽

Cross Sectional ◽

Coronary Syndrome ◽

St Elevation ◽

Sugar Levels

AbstrakSindrom Koroner Akut (SKA) merupakan spektrum dari penyakit arteri koroner yang tidak stabil, mulai dari angina pektoris tidak stabil sampai infark miokardium. SKA terbagi atas Unstable Angina Pectoris (UAP), ST elevation myocardial infarction (STEMI), Non-ST elevation myocardial infarction (NSTEMI). Tujuan penelitian ini adalah untuk menentukan hubungan antara kadar gula darah saat masuk rumah sakit dan jenis SKA. Metode penelitian yang digunakan adalah cross sectional. Penelitian dilakukan di Instalasi Rekam Medik RS Dr. M. Djamil Padang dengan mengambil data pasien SKA dari Januari 2012 sampai Desember 2012. Hasil penelitian ini didapatkan jenis SKA dengan gula darah yang tidak normal dari 60 sampel, yaitu: UAP 25%, NSTEMI 35%, STEMI 40%. Hasil pengolahan data dapat dilihat bahwa nilai p = 0,592 yang artinya tidak terdapat hubungan yang bermakna antara kadar gula darah saat masuk rumah sakit dengan jenis SKA. Hal ini terjadi mungkin karena terlalu sedikitnya sampel dan banyak sampel kriteria ekslusi dalam pencarian data. Sebaiknya dalam penelitian yang akan datang dapat memperbanyak sampel.Kata kunci: sindrom koroner akut, kadar gula darah, hubungan kadar gula darah dengan SKA AbstractAcute Coronary Syndrome (ACS) is a spectrum of coronary artery disease that is not stable, ranging from unstable angina to myocardial infarction. Acute Coronary Syndrome is divided into Unstable Angina Pectoris (UAP), ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI). The objective of this study was to determine the relationship between blood sugar levels when admitted to hospital and Acute Coronary Syndrome type by using cross sectional study. The study was conducted at the Medical Records RS Dr. M. Djamil Padang. The ACS data collected from January 2012 until December 2012. The results of this study was found the SKA with abnormal blood sugar of 60 samples, i.e. UAP25%, NSTEMI35%, 40% STEMI. On the results of data processing can be seen that the value of p=0.592, which means there is no significant correlation between blood sugar levels upon hospital admission and the type of SKA. No relationship because of little samples and exclusion criteria. The further study has to used more samples.Keywords: acute coronary syndrome, blood sugar levels, blood sugar relationship with acute coronary syndrome

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Circulating Levels of Dephosphorylated-Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome

Molecules ◽

10.3390/molecules26041108 ◽

2021 ◽

Vol 26 (4) ◽

pp. 1108

Author(s):

Admira Bilalic ◽

Tina Ticinovic Kurir ◽

Marko Kumric ◽

Josip A. Borovac ◽

Andrija Matetic ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

High Risk ◽

Hospital Mortality ◽

Vascular Calcification ◽

Matrix Gla Protein ◽

St Elevation Myocardial Infarction ◽

Coronary Syndrome ◽

Increased Risk ◽

St Elevation

Vascular calcification contributes to the pathogenesis of coronary artery disease while matrix Gla protein (MGP) was recently identified as a potent inhibitor of vascular calcification. MGP fractions, such as dephosphorylated-uncarboxylated MGP (dp-ucMGP), lack post-translational modifications and are less efficient in vascular calcification inhibition. We sought to compare dp-ucMGP levels between patients with acute coronary syndrome (ACS), stratified by ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) status. Physical examination and clinical data, along with plasma dp-ucMGP levels, were obtained from 90 consecutive ACS patients. We observed that levels of dp-ucMGP were significantly higher in patients with NSTEMI compared to STEMI patients (1063.4 ± 518.6 vs. 742.7 ± 166.6 pmol/L, p < 0.001). NSTEMI status and positive family history of cardiovascular diseases were only independent predictors of the highest tertile of dp-ucMGP levels. Among those with NSTEMI, patients at a high risk of in-hospital mortality (adjudicated by GRACE score) had significantly higher levels of dp-ucMGP compared to non-high-risk patients (1417.8 ± 956.8 vs. 984.6 ± 335.0 pmol/L, p = 0.030). Altogether, our findings suggest that higher dp-ucMGP levels likely reflect higher calcification burden in ACS patients and might aid in the identification of NSTEMI patients at increased risk of in-hospital mortality. Furthermore, observed dp-ucMGP levels might reflect differences in atherosclerotic plaque pathobiology between patients with STEMI and NSTEMI.

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Aspiration Thrombectomy in Patients With ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the Acute Coronary Syndrome Israeli Survey 2010)

The American Journal of Cardiology ◽

10.1016/j.amjcard.2013.11.032 ◽

2014 ◽

Vol 113 (5) ◽

pp. 809-814 ◽

Cited By ~ 2

Author(s):

Mady Moriel ◽

Shlomi Matetzky ◽

Amit Segev ◽

Aaron Medina ◽

Ran Kornowski ◽

...

Keyword(s):

Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Acute Coronary Syndrome ◽

Primary Percutaneous Coronary Intervention ◽

Coronary Intervention ◽

St Elevation Myocardial Infarction ◽

Aspiration Thrombectomy ◽

Coronary Syndrome ◽

Percutaneous Coronary ◽

St Elevation

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The Study of Serum Calcium to Magnesium Ratio in Patients with Acute Coronary Syndrome in a Tertiary Hospital, Hubli, Karnataka

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/644 ◽

2021 ◽

Vol 8 (41) ◽

pp. 3553-3558

Author(s):

Uday Subhash Bande ◽

Kalinga Bommanakatte Eranaik ◽

Manjunath Shivalingappa Hiremani ◽

Basawantrao Kailash Patil ◽

Sushma Shankaragouda Biradar

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Roc Analysis ◽

St Elevation Myocardial Infarction ◽

P Value ◽

Operating Characteristics ◽

Coronary Syndrome ◽

Function Tests ◽

Creatine Kinase Mb ◽

St Elevation

BACKGROUND Cardiovascular diseases are one of the leading causes of morbidity and mortality worldwide. High Ca levels and low Mg levels are associated with increased cardiovascular risk in the general population.1 The balance between Ca and Mg seems to play an important role in homeostasis since Mg is considered as physiologic antagonist of Ca.2 Hence Ca/Mg ratio was considered to study its association with acute coronary syndrome (ACS). METHODS This is a case control study conducted in Karnataka Institute of Medical Sciences, Hubli over a period of 2 years, February 2019 to December 2020. 200 cases and 150 controls were included in the study. The biochemical measurements including complete blood count (CBC), cardiac biomarkers, liver function tests, renal function tests (RFT), serum electrolytes and lipid profile were measured using standard laboratory methods. Student ‘t’ test was used to compare the data. Optimum cut-offs for diagnosis of acute myocardial infarction was calculated using receiver operating characteristics (ROC) analysis. The association among markers was established by calculating Pearson’s correlation. RESULTS Serum Ca/Mg ratio was significantly higher (p value < 0.001) in ACS when compared to control groups. It was also found that Ca/Mg ratio was significantly lower (p value < 0.001) in non-ST elevation myocardial infarction (NSTEMI) when compared to STEMI group. Serum Mg was significantly lower (p value < 0.001) in ACS group when compared to control group. Significant correlation (p value < 0.05) was found between serum Ca/Mg ratio and cardiac markers (CKMB, Troponin-I). ROC analysis of Ca/Mg (4.19) ratios showed optimum cut-offs in diagnosis of AMI. CONCLUSIONS Serum Ca/Mg could be useful adjuvant marker in diagnosis of AMI. The ratio is higher in ST-segment elevation myocardial infarction when compared to non-STsegment myocardial infarction, which could be due to greater decrease in Mg levels when compared Ca in ACS. KEYWORDS ST Elevation Myocardial Infarction (STEMI), Non ST Elevation Myocardial Infarction (NSTEMI), Calcium (Ca), Magnesium (Mg), Acute Coronary Syndrome (ACS), Creatine Kinase-MB (CK-MB).

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