New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment: application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor

The aim of the study was to develop and evaluate a self- -emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary phase diagrams were plotted to identify the microemulsification existence area. SEDDS formulation of ABZ was prepared using oil (Labrafac Lipopfile WL1349) and a surfactant/ co-surfactant (Tween 80/PEG 400) mixture and was characterized by appropriate studies, viz., microemulsifying properties, droplet size measurement, in vitro dissolution, etc. Finally, PK of the ABZ SEDDS formulation was performed on rats in parallel with suspension formulation. It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ.

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Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs

Journal of Pharmaceutical Investigation ◽

10.1007/s40005-021-00516-0 ◽

2021 ◽

Author(s):

Phuong Tran ◽

Jeong-Sook Park

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Oral Bioavailability ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Recent Trends ◽

Poorly Water Soluble

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New drug delivery system for brain tumor chemotherapy using 40.DEG.C.-adriamycin thermosensitive liposome.

Drug Delivery System ◽

10.2745/dds.11.351 ◽

1996 ◽

Vol 11 (5) ◽

pp. 351-354 ◽

Cited By ~ 1

Author(s):

Kenichi Kakinuma ◽

Ryuichi Tanaka ◽

Masashi Kato ◽

Hideaki Takahashi ◽

Tsuyoshi Suda ◽

...

Keyword(s):

Drug Delivery ◽

Brain Tumor ◽

Drug Delivery System ◽

Delivery System ◽

New Drug ◽

Thermosensitive Liposome ◽

Brain Tumor Chemotherapy

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Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System of Naproxen

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.1.3 ◽

2015 ◽

Vol 8 (1) ◽

pp. 2715-2722

Author(s):

Saritha D ◽

Penjuri Subhash Chandra Bose ◽

Nagaraju Ravoru

Keyword(s):

Drug Delivery ◽

Oral Administration ◽

Drug Delivery System ◽

Delivery System ◽

Water Soluble ◽

Size Analysis ◽

Albino Rats ◽

Significant Activity ◽

Water Soluble Drugs

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nanoemulsions containing the solubilized drug. The objective of the present work was to formulate a self nanoemulsifying drug delivery system (SNEDDS) for naproxen. Naproxen SNEDDS were formulated using Labrafac PG (Oil), Span 80 (Surfactant) and propylene glycol (Co surfactant). The developed SNEDDS were evaluated for turbidimetry, droplet size analysis, zeta potential, refractive index, viscosity, drug content and in vitro diffusion profiles. All formulations of naproxen SNEDDS showed globule size in nanometric range, good stability with no phase separation and rapidly formed clear emulsion. All formulations showed more than 95% of drug release at the end of 60 min. The SEDDS showed improved dissolution rate compared to pure naproxen. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SNEDDS showed more significant activity than the pure drug. The study illustrated the potential of naproxen SNEDDS for oral administration and its biopharmaceutical performance.

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