A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VI. Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Water-Soluble Polymers as a Wall Material.

AbstractNew drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.

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Microencapsulation: A potential and promising approach in drug delivery system

Journal of Inventions in Biomedical and Pharmaceutical Sciences ◽

10.26452/jibps.v1i1.1420 ◽

2016 ◽

Vol 1 (1) ◽

pp. 30-39

Author(s):

Madiha Jabeen ◽

Shireen Begum ◽

Aroosa Siddique ◽

Syeda Saniya Fatima

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery System ◽

Delivery System ◽

Core Material ◽

Wall Material ◽

The Core ◽

Novel Drug Delivery System ◽

Reduced Toxicity ◽

Novel Drug

Novel drug delivery system is a method by which drug delivered can have significant effect on its efficacy. There are several advantages of novel drug delivery system over conventional multi dose therapy, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. Many efforts have been made in developing novel drug delivery system, which emphasizes on controlled and sustained release dosage forms to obtain optimum benefits. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres or microcapsules. Microencapsulation is a process by which solids, liquids or gases can be enclosed in microscopic particles by forming a thin coating of wall material around substances, which protects it from external environment and control the drug release yielding capsules ranging for one micron to several hundred microns in size (1µ- 800µ). There are different microencapsulation techniques, which are used to obtain microcapsules for controlled release of drug. The morphology of microcapsules depends on the core material and deposition of coating material. Substances may be microencapsulated for the purpose of confining core material within capsule wall for specific period of time. Core materials are also encapsulated so that the core material can be gradually released (controlled release or diffusion) or when external conditions trigger the capsule walls to rupture, melt, or dissolve. Microencapsulation has found many applications in science and technology.

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