An electron microscopy study of legionella pneumophila after in vitro and in vivo

1988 ◽  
Vol 269 (1) ◽  
pp. 26-33 ◽  
Author(s):  
M. Surgot ◽  
C.M. Barioz ◽  
M. Nowicki ◽  
N. Bornstein ◽  
J. Fleurette
Keyword(s):  
Electron Microscopy ◽  
Legionella Pneumophila ◽  
Microscopy Study ◽  
Electron Microscopy Study

Cytological changes induced by platinum-thymine in sarcoma-180 cells: Electron microscopy study

1990 ◽  
Vol 48 (3) ◽  
pp. 290-291
Author(s):  
Gustav Ofosu
Keyword(s):  
Mammalian Cells ◽  
Antitumor Agent ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Limiting Factor ◽  
Sarcoma 180 ◽  
Electron Microscopic ◽  
Cytological Changes

Platinum-thymine has been found to be a potent antitumor agent, which is quite soluble in water, and lack nephrotoxicity as the dose-limiting factor. The drug has been shown to interact with DNA and inhibits DNA, RNA and protein synthesis in mammalian cells in vitro. This investigation was undertaken to elucidate the cytotoxic effects of piatinum-thymine on sarcoma-180 cells in vitro ultrastructurally, Sarcoma-180 tumor bearing mice were treated with intraperitoneal injection of platinum-thymine 40mg/kg. A concentration of 60μg/ml dose of platinum-thymine was used in in vitro experiments. Treatments were at varying time intervals of 3, 7 and 21 days for in vivo experiments, and 30, 60 and 120 min., 6, 12, and 24th in vitro. Controls were not treated with platinum-thymine.Electron microscopic analyses of the treated cells in vivo and in vitro showed drastic cytotoxic effect.

scholarly journals Ultrastructural alterations of intracellular stages and effects on blood forms of Trypanosoma cruzi induced in vivo by 2-amino-5-(1-methyil-5-nitro-2-imidazolyl)-1,3,4 - Thiadiazole

1984 ◽  
Vol 17 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Thaisa de Almeida Maria ◽  
Leny de Sousa Filardi ◽  
Zigman Brener
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Trypanosoma Cruzi ◽  
Drug Administration ◽  
Active Drug ◽  
Developmental Stages ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Ultrastructural Alterations

An electron microscopy study shows that the administration of a single dose (500 mg/kg, p.o.) of 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1, 3, 4-thiadiazole induces in mice infected with Trypanosoma cruzi results in degenerative lesions of the intracellular stages. Ultrastructural alterations are detected as early as 6 hours after the drug administration and destruction of the parasites occurs within 18 - 36 hours. Trypomastigotes are cleared from the bloodstream 4 to 6 hours after treatment. The combined effect on both developmental stages is apparently responsible for the in vivo ejfects of this drug which is the most active drug ever tested in our laboratory in experimental Chagas' disease.

The effect of benzalkonium chloride on rabbit nasal mucosa in vivo: an electron microscopy study

2002 ◽  
Vol 259 (7) ◽  
pp. 362-364 ◽  
Author(s):  
Sebahattin Cüreoğlu ◽  
Murat Akkuş ◽  
Üstün Osma ◽  
Mehmet Yaldiz ◽  
Faruk Oktay ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Nasal Mucosa ◽  
Benzalkonium Chloride ◽  
Microscopy Study ◽  
Electron Microscopy Study
Sign in / Sign up

Export Citation Format

Share Document