Rapid spread of penicillin-resistant Streptococcus pneumoniae among high-risk hospital inpatients and the role of molecular typing in outbreak confirmation

2003 ◽  
Vol 54 (2) ◽  
pp. 99-103 ◽  
Author(s):  
D Subramanian ◽  
J.A.T Sandoe ◽  
V Keer ◽  
M.H Wilcox
Keyword(s):  
Streptococcus Pneumoniae ◽  
High Risk ◽  
Molecular Typing ◽  
Rapid Spread ◽  
Hospital Inpatients

scholarly journals The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical Model Approach

2020 ◽  
Vol 21 (22) ◽  
pp. 8428
Author(s):  
Guido Santos ◽  
Julio Vera
Keyword(s):  
Mathematical Model ◽  
Streptococcus Pneumoniae ◽  
High Risk ◽  
Young Patients ◽  
Alveolar Epithelium ◽  
Neutrophil Infiltration ◽  
Aged Patients ◽  
Effective Response ◽  
Multi Level

Bacterial pneumonia is one of the most prevalent infectious diseases and has high mortality in sensitive patients (children, elderly and immunocompromised). Although an infection, the disease alters the alveolar epithelium homeostasis and hinders normal breathing, often with fatal consequences. A special case is hospitalized aged patients, which present a high risk of infection and death because of the community acquired version of the Streptococcus pneumoniae pneumonia. There is evidence that early antibiotics treatment decreases the inflammatory response during pneumonia. Here, we investigate mechanistically this strategy using a multi-level mathematical model, which describes the 24 first hours after infection of a single alveolus from the key signaling networks behind activation of the epithelium to the dynamics of the local immune response. With the model, we simulated pneumonia in aged and young patients subjected to different antibiotics timing. The results show that providing antibiotics to elderly patients 8 h in advance compared to young patients restores in aged individuals the effective response seen in young ones. This result suggests the use of early, probably prophylactic, antibiotics treatment in aged hospitalized people with high risk of pneumonia.

Etiological role of multiresistant Streptococcus pneumoniae in acute purulent otitis media in children

2017 ◽  
Vol 96 (6) ◽  
pp. 92-98 ◽  
Author(s):  
I.N. Protasova ◽  
◽  
S.V. Domracheva ◽  
O.Yu. Volkova ◽  
V.A. Kalenskij ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Otitis Media ◽  
Etiological Role

The role of antioxidants in high risk pregnancy

GYNECOLOGY ◽  
2014 ◽  
Vol 16 (1) ◽  
pp. 86-92
Author(s):  
I.V. Bakhareva ◽  
Keyword(s):  
High Risk ◽  
High Risk Pregnancy ◽  
Risk Pregnancy

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

ON THE ROLE OF BIOMONITORING IN THE ASSESSMENT OF THE HEALTH OF THE POPULATION EXPOSED TO MERCURY

2017 ◽  
pp. 2-7
Author(s):  
L. V. Lukovnikova ◽  
G. I. Sidorin ◽  
L. A. Alikbaeva ◽  
A. V. Galochina
Keyword(s):  
High Risk ◽  
Biological Monitoring ◽  
Clinical Examination ◽  
Inorganic Compounds ◽  
Risk Groups ◽  
Comprehensive Approach ◽  
Chemical Monitoring ◽  
Environmental Objects

When examining the population exposed to organic and inorganic compounds of mercury, a comprehensive approach is proposed, including chemical monitoring of environmental objects, biological monitoring, clinical examination of persons exposed to mercury, identification of high-risk groups.

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