Apo E and apo E receptor gene expression in the brain of Alzheimer's disease subjects with different apoE genotype

2000 ◽  
Vol 21 ◽  
pp. 115
Author(s):  
Doris Dea ◽  
Nicole Aumont ◽  
Judes Poirier
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Receptor Gene ◽  
Apoe Genotype ◽  
Apo E ◽  
The Brain ◽  
Receptor Gene Expression

scholarly journals Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease

2020 ◽  
Vol 81 (3) ◽  
pp. e33-e34 ◽  
Author(s):  
Key-Hwan Lim ◽  
Sumin Yang ◽  
Sung-Hyun Kim ◽  
Jae-Yeol Joo
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Receptor Gene ◽  
Entry Receptor ◽  
Receptor Gene Expression

Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease

1993 ◽  
Vol 18 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Jonathan R. Seckl ◽  
Karen L. French ◽  
Dajan O'Donnell ◽  
Michael J. Meaney ◽  
N.P.V. Nair ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucocorticoid Receptor ◽  
Hippocampal Neurons ◽  
Receptor Gene ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression

Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer’s Disease Model

2016 ◽  
Vol 55 (3) ◽  
pp. 1273-1283 ◽  
Author(s):  
Jesus Mendiola-Precoma ◽  
Karla Padilla ◽  
Alfredo Rodríguez-Cruz ◽  
Laura C. Berumen ◽  
Ricardo Miledi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Brain ◽  
Purinergic Receptor ◽  
Receptor Gene ◽  
Disease Model ◽  
Induced Changes ◽  
Receptor Gene Expression

scholarly journals Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Angela M. Crist ◽  
Kelly M. Hinkle ◽  
Xue Wang ◽  
Christina M. Moloney ◽  
Billie J. Matchett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Digital Pathology ◽  
Selective Vulnerability ◽  
Brain Regions ◽  
Biochemical Analyses ◽  
The Brain ◽  
Relevant Gene ◽  
Tau Expression

AbstractSelective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs among patients. We classified corticolimbic patterns of neurofibrillary tangles in postmortem tissue to capture extreme and representative phenotypes. We combined bulk RNA sequencing with digital pathology to examine hippocampal vulnerability in AD. We identified hippocampal gene expression changes associated with hippocampal vulnerability and used machine learning to identify genes that were associated with AD neuropathology, including SERPINA5, RYBP, SLC38A2, FEM1B, and PYDC1. Further histologic and biochemical analyses suggested SERPINA5 expression is associated with tau expression in the brain. Our study highlights the importance of embracing heterogeneity of the human brain in disease to identify disease-relevant gene expression.

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