scholarly journals ECTHYMA GANGRENOSUM: A RARE CUTANEOUS MANIFESTATION CAUSED BY PSEUDOMONAS AERUGINOSA WITHOUT BACTERAEMIA IN A LEUKAEMIC PATIENT- A CASE REPORT

2005 ◽  
Vol 23 (4) ◽  
pp. 262-263
Author(s):  
TN Singh ◽  
KM Devi ◽  
KS Devi
1993 ◽  
Vol 29 (1) ◽  
pp. 104-106 ◽  
Author(s):  
Luis Diego Sevinsky ◽  
Claudia Viecens ◽  
Daniel Omar Ballesteros ◽  
Fernando Stengel

2019 ◽  
Vol 10 (4) ◽  
pp. 2745-2747
Author(s):  
Kiran Madhusudhan ◽  
Madhusudhan

Ecthyma gangrenosum is a skin manifestation of Pseudomonas aeruginosa in immunocompromised individuals. Here we report a case of a 64-year-old diabetic female with Ecthyma gangrenosum lesions on both lower limbs, admitted for surgical debridement. Pus culture taken during surgery showed growth of Methicillin-resistant Staphylococcus aureus. The patient was started on appropriate antibiotics with reasonable glycemic control using parenteral insulin. The patient responded well to the above treatment and was discharged.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Haixia Huang ◽  
Ke Bai ◽  
Yueqiang Fu ◽  
Jin Yan ◽  
Jing Li

Abstract Background X-linked agammaglobulinemia (XLA, OMIM#300,300), caused by mutations in the Bruton tyrosine kinase (BTK) gene, is a rare monogenic inheritable immunodeficiency disorder. Ecthyma gangrenosum is a cutaneous lesion caused by Pseudomonas aeruginosa that typically occurs in patients with XLA and other immunodeficiencies. Case presentation We report the case of a 20-month-old boy who presented with fever, vomiting, diarrhea, and ecthyma gangrenosum. Blood, stool, and skin lesion culture samples were positive for P. aeruginosa. A diagnosis of XLA was established, and the c.262G > T mutation in exon 4 of BTK was identified with Sanger sequencing. Symptoms improved following treatment with antibiotics and immunoglobulin infusion. Conclusions Primary immunodeficiency (i.e., XLA) should be suspected in male infants with P. aeruginosa sepsis, highlighting the importance of genetic and immune testing in these patients.


2017 ◽  
Vol 4 (83) ◽  
pp. 4919-4920
Author(s):  
Ravichander B ◽  
Sayid Mohammed Muflih ◽  
Ahirrao Varsha Suresh

2019 ◽  
Vol 72 (3-4) ◽  
pp. 119-121
Author(s):  
Mirjana Tomic ◽  
Ivanka Percic ◽  
Danijela Agic ◽  
Nada Vlaisavljevic ◽  
Borivoj Sekulic ◽  
...  

Introduction. Ecthyma gangrenosum is a rare skin disorder which commonly affects immunocompromised patients. Case Report. We report two hematological patients suffering from ecthyma gangrenosum. Pseudomonas aeruginosa was isolated from skin lesions of both patients, but bacteremia was present only in the first case. These two cases had different pathogenic mechanisms and outcomes. Conclusion. Early diagnosis and prompt combination antibiotic therapy are of utmost importance in the treatment of this condition. On the other hand, the underlying disease has a great impact on the outcome as well.


2010 ◽  
Vol 72 (2) ◽  
pp. 111-115
Author(s):  
Hiroyuki KAYO ◽  
Yutaka ASATO ◽  
Kiyohito TAIRA ◽  
Yu-ichi YAMAMOTO ◽  
Yuko HANNITA ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gabriela M. Wiedemann ◽  
Jochen Schneider ◽  
Mareike Verbeek ◽  
Björn Konukiewitz ◽  
Christoph D. Spinner ◽  
...  

Abstract Background Ecthyma gangrenosum (EG) is a cutaneous infectious disease characterized by eschar-like skin ulcers typically caused by Pseudomonas aeruginosa. Here, we report a case of relapsing EG in a patient who had returned from a trip to Colombia, thus establishing EG as an important differential diagnosis of tropical diseases, and demonstrating that even long-term antibiotic treatment can result in only partial remission of EG. Case presentation A 77-year-old man with underlying chronic lymphocytic leukemia (CLL) on ibrutinib treatment was admitted because of a superinfected mosquito bite on the left ear and multiple partially necrotic skin lesions disseminated all over the entire body five days after returning from a trip to Colombia. The initial clinical suspicion of a tropical disease (leishmaniosis, systemic mycosis, or others) could not be confirmed. During the diagnostic workup, microbiological cultures of the skin biopsies and bronchoalveolar lavage revealed Pseudomonas aeruginosa, leading to a diagnosis of EG. Initial antibiotic treatment resulted in partial remission. However, the patient had to be re-admitted due to a relapse 3–4 weeks after the first episode. Finally, the patient was successfully treated with a combined approach consisting of antibiotics, recurrent surgical incisions, and administration of immunoglobulins. Conclusions In conclusion, EG should be considered as a differential diagnosis in immunosuppressed patients presenting with eschar-like skin ulcers. A combined treatment approach seems to be the best choice to achieve clinical cure and avoid relapse.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Edyta Gołembiewska ◽  
Kazimierz Ciechanowski

Abstract Background Infectious complications of peritoneal dialysis (PD) remain a common cause of catheter loss and discontinuation of PD. Exit site infection (ESI) constitutes a significant risk factor for PD-related peritonitis and determination of predisposing states is relevant. We here present a case of repeat ESI due to Pseudomonas aeruginosa in a PD patient with skin changes in the course of polycythemia vera (PV). Case presentation A 73-year-old PD patient with chronic kidney disease secondary to renal amyloidosis and ankylosing spondylitis, presented to the nephrology unit with signs of ESI. In 2006 he was diagnosed with PV and since then has was successfully treated with hydroxyurea; however, he reported recurrent episodes of developing skin nodules in the course of the disease. Exit site swab yielded Pseudomonas aeruginosa and the infection developed in the ulcerated PV nodule that appeared in exit site 2 weeks earlier. Patient was treated with intraperitoneal amikacin and oral ciprofloxacin, however, due to neurological complications, the treatment had to be interrupted and finally catheter was removed. Similar episode of ESI with Pseudomonas aeruginosa developed in the patient two years earlier and also required catheter removal. Conclusion This is the first case report demonstrating the development of ESI on the polycythemia vera skin lesion in this area. Skin manifestations of PV might be a predisposing factor to ESI in PD patients.


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